Article Figures & Data
Figures
- FIGURE 1.
SPECT images (vertical long axes) from representative patient. 99mTc-Tetrofosmin SPECT shows stress-induced ischemia at baseline in inferior wall (arrow). At 3-mo follow-up, ischemia in inferior wall has resolved. Metabolic imaging shows normal 18F-FDG uptake at baseline and 3-mo follow-up in that region, indicating no scar formation after intramyocardial injection of bone marrow–derived mononuclear cells.
- FIGURE 2.
Patients' segmental stress and rest scores improved significantly 3 mo after autologous bone marrow–derived mononuclear cell injection. Magnitude of increase in stress score was significantly higher as observed for rest score.
- FIGURE 3.
Patients' gated 99mTc-tetrofosmin SPECT segmental stress and rest scores in injected and noninjected segments. (A) Patients' segmental stress score improved in injected and noninjected segments. Improvement in injected segments was more pronounced than improvement in noninjected segments. (B) There was a trend toward improvement in rest score in injected and noninjected segments. Magnitude of improvement in rest score was similar in injected and noninjected segments.
Tables
Parameter n % Age (y) 64 ± 10 Sex (M) 21/25 84 Systemic hypertension 12/25 48 Diabetes mellitus 13/25 52 Insulin dependent 7/25 28 Non–insulin dependent 6/25 24 Hyperlipidemia 22/25 88 Smoking 2/25 8 Coronary artery disease in family 18/25 72 Body mass index 28 ± 4 Prior myocardial infarction 18/25 72 Prior percutaneous coronary intervention 19/25 76 Prior coronary artery bypass grafting 22/25 88 Current medication Nitrates 25/25 100 β-Blockers 23/25 92 Calcium channel blockers 18/25 72 Statins 24/25 96 Angiotensin-converting enzyme inhibitors 19/25 76 Stress test data Baseline 3-mo follow-up P value Level of stress achieved (W) 130 ± 32 135 ± 35 0.10 Heart rate at rest (bpm) 73 ± 15 70 ± 15 NS SBP at rest (mm Hg) 136 ± 18 136 ± 18 NS DBP at rest (mm Hg) 78 ± 11 75 ± 13 NS Maximal heart rate at stress (bpm) 105 ± 29 103 ± 30 NS Maximal SBP at stress (mm Hg) 154 ± 32 157 ± 31 NS Maximal DBP at stress (mm Hg) 78 ± 12 76 ± 15 NS bpm = beats per minute; SBP = systolic blood pressure; DBP = diastolic blood pressure.
LV ejection fraction and volumes Baseline 3-mo follow-up P value LV ejection fraction (%) 47.6 ± 13.5 54.1 ± 16.9 <0.01 LV end-systolic volume (mL) 81 ± 68 75 ± 70 <0.01 LV end-diastolic volume (mL) 137 ± 80 139 ± 82 NS Segments Improved perfusion No improved perfusion P value Injected 48/91 43/91 <0.01 Noninjected 45/334 289/334 Improved perfusion ≥ 1 point increase in stress or rest perfusion.
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