Article Figures & Data
Figures
- FIGURE 1.
Test (left column) and retest (right column) parametric images of BP (top row) and R1 (bottom row) of a representative subject. Th = thalamus; Ra = raphe; Hyp = hypothalamus; Cg = cingulate gyrus.
- FIGURE 2.
MRI superimposed with t-statistic maps obtained from SPM comparing test and retest studies using height threshold of uncorrected P = 0.05 and extent threshold of 100 voxels. (A) t-statistic maps comparing BP values of test and retest (test > retest). (B) t-statistic maps comparing R1 values of test and retest (test < retest).
Tables
k′2 (min−1)* Subject no. Age (y) Sex Test Retest % difference 1 41 M 0.049 0.052 6.6 2 41 F 0.067 0.073 9.5 3 21 M 0.066 0.066 −0.1 4 20 M 0.055 0.058 5.4 5 22 F 0.082 0.076 −7.1 6 24 F 0.079 0.077 −3.0 7 23 F 0.079 0.079 −0.6 8 19 F 0.051 0.056 9.7 Mean ± SD 26 ± 9 0.066 ± 0.013 0.067 ± 0.011 2.5 ± 6.2 ↵* Mean
value estimated with MRTM model on thalamus, striatum, and raphe time–activity curve with cerebellum as a reference region.
- TABLE 2
Test–Retest Bias, Variability, and Reliability of BP Estimated by MRTM2 Parametric Imaging Method
BP (mean ± SD; n = 8) Region Test Retest Bias (%) Variability (%) Reliability (ρ) Striatum 1.38 ± 0.18 1.31 ± 0.14 −4.8 4.5 0.83 Thalamus 2.10 ± 0.34 1.94 ± 0.31 −7.5 4.1 0.85 Raphe 3.24 ± 0.27 3.00 ± 0.20 −7.0 4.8 0.45 Frontal cortex 0.41 ± 0.05 0.38 ± 0.03 −6.9 8.7 0.44 Temporal cortex 0.58 ± 0.13 0.56 ± 0.11 −2.5 8.9 0.85 Occipital cortex 0.39 ± 0.11 0.37 ± 0.08 −4.3 12.8 0.83 - TABLE 3
Test–Retest Bias, Variability, and Reliability of R1 Estimated by MRTM2 Parametric Imaging Method
R1 (mean ± SD; n = 8) Region Test Retest Bias (%) Variability (%) Reliability (ρ) Striatum 1.03 ± 0.07 1.02 ± 0.07 −0.9 2.5 0.92 Thalamus 1.03 ± 0.08 1.02 ± 0.06 −0.8 6.1 0.62 Raphe 0.77 ± 0.08 0.76 ± 0.05 −0.9 5.7 0.73 Frontal cortex 0.97 ± 0.11 0.97 ± 0.11 −0.6 3.5 0.95 Temporal cortex 0.71 ± 0.05 0.71 ± 0.07 0.0 4.3 0.87 Occipital cortex 1.00 ± 0.06 1.03 ± 0.08 3.0 6.4 0.58 - TABLE 4
Test–Retest Bias, Variability, and Reliability of BP Estimated by ROI Time–Activity Curve-Fitting Method
BP (mean ± SD; n = 8) Region Test Retest Bias (%) Variability (%) Reliability (ρ) Striatum 1.38 ± 0.19 1.32 ± 0.16 −4.3 3.7 0.89 Thalamus 2.04 ± 0.34 1.88 ± 0.30 −7.5 4.6 0.84 Raphe 3.16 ± 0.26 2.93 ± 0.19 −7.0 5.3 0.39 Frontal cortex 0.40 ± 0.06 0.37 ± 0.03 −6.8 8.0 0.55 Temporal cortex 0.53 ± 0.13 0.51 ± 0.10 −2.7 9.7 0.82 Occipital cortex 0.39 ± 0.12 0.36 ± 0.09 −4.5 13.2 0.85 - TABLE 5
Test–Retest Bias, Variability, and Reliability of R1 Estimated by ROI Time–Activity Curve-Fitting Method
R1 (mean ± SD; n = 8) Region Test Retest Bias (%) Variability (%) Reliability (ρ) Striatum 1.03 ± 0.07 1.02 ± 0.07 −1.1 2.9 0.89 Thalamus 1.03 ± 0.08 1.01 ± 0.06 −1.0 6.3 0.55 Raphe 0.77 ± 0.08 0.76 ± 0.04 −1.0 6.3 0.67 Frontal cortex 0.96 ± 0.11 0.96 ± 0.11 −0.7 3.2 0.96 Temporal cortex 0.69 ± 0.05 0.69 ± 0.06 0.0 4.6 0.85 Occipital cortex 1.00 ± 0.07 1.02 ± 0.08 2.8 6.5 0.60
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