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OtherClinical Investigations

Detection of Klatskin’s Tumor in Extrahepatic Bile Duct Strictures Using Delayed 18F-FDG PET/CT: Preliminary Results for 22 Patient Studies

Michael J. Reinhardt, Holger Strunk, Thomas Gerhardt, Roland Roedel, Ursula Jaeger, Jan Bucerius, Tilman Sauerbruch, Hans-Juergen Biersack and Franz L. Dumoulin
Journal of Nuclear Medicine July 2005, 46 (7) 1158-1163;
Michael J. Reinhardt
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Holger Strunk
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Thomas Gerhardt
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Roland Roedel
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Ursula Jaeger
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Jan Bucerius
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Tilman Sauerbruch
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Hans-Juergen Biersack
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Franz L. Dumoulin
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  • FIGURE 1.
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    FIGURE 1.

    18F-FDG PET/CT of patient with no evidence of malignancy after PDT. (A) Native CT image shows discrete hypodense areas in liver segments 4B and 5. (B) Fused image (CT, 50%; PET, 50%) enables anatomic correlation of glucose metabolism. (C) 18F-FDG PET image shows 75% and 100% isocontour areas used for SUV analysis (SUVmax = 3.2 and SUV75% = 2.5). Note atrophy of left liver lobe.

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    FIGURE 2.

    18F-FDG PET/CT of patient with residual Klatskin’s tumor after PDT and Yamakawa stent implantation. (A) Native CT image shows large hypodense area in liver hilus. (B) Fused image (CT, 50%; PET, 50%) enables anatomic correlation of increased glucose metabolism. (C) 18F-FDG PET image shows 75% and 100% isocontour areas used for SUV analysis (SUVmax, 5.0, and SUV75%, 4.1).

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    FIGURE 3.

    Box plot analysis of perihilar SUVmax in 22 patient studies with and without cholangiocarcinoma. ○ = outliers; * = extreme cases; CC = cholangiocarcinoma.

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    FIGURE 4.

    Box plot analysis of perihilar SUV75% in 22 patient studies with and without cholangiocarcinoma. ○ = outliers; * = extreme cases; CC = cholangiocarcinoma.

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    TABLE 1

    Characteristics, 18F-FDG PET/CT Indications, Perihilar SUV, Histology, and Outcome of 20 Patients with Extrahepatic Bile Duct Strictures

    Patient no.Age (y)SexIndication for 18F-FDG PET/CTPerihilar SUVmaxPerihilar SUV75%HistologyOutcome
    163FStaging before surgery3.93.1CCCurative resection
    246MStaging before surgery5.24.3CCCurative resection
    368MStaging before surgery6.15.1CCCurative resection
    466FStaging before surgery6.65.6CCCurative resection
    571MStaging before PDT5.24.2CCStable disease
    675MStaging before PDT6.35.2CCStable disease
    776MStaging before PDT9.88.2CCStable disease
    Tx control after PDT11.09.0CCDisease progress on CT 5 mo later
    877FTx control after PDT15.811.8CCDisease progress on CT 6 mo later
    976MTx control after PDT5.24.3CCStable disease for 6 mo
    Follow-up after 6 mo7.15.9CCDisease progress on CT 7 mo later
    1061FTx control after PDT3.93.2CCDisease progress on CT 9 mo later
    1164FTx control after PDT5.04.1CCDisease progress on CT 14 mo later
    1278FExclusion of CC*4.23.5CCCurative resection
    1364MExclusion of CC*3.22.7No CC12-mo follow-up negative
    1482FExclusion of CC*2.72.2No CC18-mo follow-up negative
    1559MExclusion of CC*3.02.2No CC20-mo follow-up negative
    1663MExclusion of CC*2.92.3No CC21-mo follow-up negative
    1760MPSC, exclusion of CC*3.12.4No CC18-mo follow-up negative
    1835FPSC, exclusion of CC*2.72.2No CC19-mo follow-up negative
    1937FPSC, exclusion of CC*2.52.1No CC20-mo follow-up negative
    2071FTx control after PDT of CC3.02.5No CC18-mo follow-up negative
    • ↵* To avoid surgery when 18F-FDG PET/CT gave no evidence of malignancy.

    • CC = cholangiocarcinoma; Tx = therapy.

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Journal of Nuclear Medicine: 46 (7)
Journal of Nuclear Medicine
Vol. 46, Issue 7
July 1, 2005
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Detection of Klatskin’s Tumor in Extrahepatic Bile Duct Strictures Using Delayed 18F-FDG PET/CT: Preliminary Results for 22 Patient Studies
Michael J. Reinhardt, Holger Strunk, Thomas Gerhardt, Roland Roedel, Ursula Jaeger, Jan Bucerius, Tilman Sauerbruch, Hans-Juergen Biersack, Franz L. Dumoulin
Journal of Nuclear Medicine Jul 2005, 46 (7) 1158-1163;

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Detection of Klatskin’s Tumor in Extrahepatic Bile Duct Strictures Using Delayed 18F-FDG PET/CT: Preliminary Results for 22 Patient Studies
Michael J. Reinhardt, Holger Strunk, Thomas Gerhardt, Roland Roedel, Ursula Jaeger, Jan Bucerius, Tilman Sauerbruch, Hans-Juergen Biersack, Franz L. Dumoulin
Journal of Nuclear Medicine Jul 2005, 46 (7) 1158-1163;
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