Article Figures & Data
Figures
- FIGURE 1.
Coronal T2-weighted (A, top) and T1-weighed (A, bottom) MR images of patient with TLE with a right mesial temporal focus and coregistered 18F-FCWAY distribution volume (V/f1, B) and CMRglu (C) images before (top) and after (bottom) PVC. Coronal images are at level of posterior hippocampus, anterior to pons. V/f1 and CMRglu images are scaled to a maximum of 100 mL/mL and 10 mg/min/100 g, respectively.
- FIGURE 2.
Relationship between percentage increase in 18F-FCWAY distribution volume (V/f1, mL/mL) and CMRglu (mg/min/100 g) in TLE patients. Each point represents mean ROI value. Regression equation was V = 21.5 + 0.90 CMRglu; r2 = 0.95; P < 0.001. Dashed line represents identity line.
- FIGURE 3.
Relationship between 18F-FCWAY BP (mL/mL) in hippocampus ipsilateral to seizure focus and BDI scale score in TLE patients before (A) and after (B) PVC. Regression equations were y = 47.6 –1.24x; r2 = 0.35, P = 0.004 (A) and y = 81.2 –1.97x; r2 = 0.26, P = 0.016 (B).
Tables
Region Before PVC After PVC Controls Patients P Controls Patients P I. Superior temporal 45 ± 15 32 ± 12 ∗ 88 ± 25 76 ± 32 C. Superior temporal 46 ± 13 36 ± 14 84 ± 23 73 ± 27 I. Middle temporal 51 ± 17 37 ± 12 ∗ 95 ± 28 79 ± 29 C. Middle temporal 52 ± 13 41 ± 15 ∗ 91 ± 23 77 ± 25 I. Inferior temporal 52 ± 18 38 ± 12 ∗ 100 ± 29 78 ± 28 C. Inferior temporal 54 ± 16 46 ± 16 97 ± 25 90 ± 32 I. Fusiform gyrus 73 ± 22 45 ± 15 ‡ 126 ± 34 80 ± 24 ‡ C. Fusiform gyrus 71 ± 23 55 ± 19 ∗ 120 ± 32 96 ± 32 I. Parahippocampus 90 ± 26 47 ± 16 ‡ 144 ± 38 83 ± 27 ‡ C. Parahippocampus 86 ± 23 59 ± 17 ‡ 144 ± 41 102 ± 30 ∗ I. Hippocampus 88 ± 21 37 ± 17 ‡ 127 ± 28 64 ± 31 ‡ C. Hippocampus 85 ± 24 58 ± 16 ‡ 124 ± 34 97 ± 30 ∗ I. Amygdala 54 ± 14 33 ± 15 ‡ 72 ± 16 50 ± 20 ∗ C. Amygdala 53 ± 14 42 ± 16 ∗ 75 ± 16 60 ± 22 I. Frontal 35 ± 11 31 ± 11 68 ± 17 66 ± 24 C. Frontal 34 ± 10 30 ± 11 65 ± 16 63 ± 23 I. Parietal 32 ± 10 26 ± 9 63 ± 17 64 ± 22 C. Parietal 31 ± 10 27 ± 11 62 ± 18 66 ± 24 I. Insula 56 ± 16 38 ± 13 ‡ 95 ± 27 63 ± 21 ‡ C. Insula 55 ± 15 40 ± 14 ∗ 95 ± 27 66 ± 21 ‡ I. Occipital 19 ± 6 17 ± 6 39 ± 10 44 ± 14 C. Occipital 18 ± 4 17 ± 6 37 ± 8 46 ± 17 Raphe 54 ± 13 38 ± 13 ∗ N/A N/A N/A Region 18F-FCWAY BP CMRglu Before PVC After PVC Before PVC After PVC Controls Patients P Controls Patients P Patients P Patients P Superior temporal −3 ± 8 −8 ± 12 4 ± 9 3 ± 30 −7 ± 13 1 ± 28 Middle temporal −5 ± 12 −7 ± 11 3 ± 8 2 ± 28 −11 ± 14 −6 ± 26 Inferior temporal −3 ± 13 −14 ± 13 ∗ 2 ± 11 −12 ± 19 ∗ −12 ± 13 −11 ± 22 Fusiform gyrus 3 ± 11 −17 ± 21 ∗ 4 ± 13 −15 ± 23 ∗ −12 ± 14 −11 ± 20 Parahippocampus 4 ± 5 −21 ± 16 ‡ 1 ± 8 −20 ± 16 ∗ −8 ± 12 ‡ −8 ± 14 § Hippocampus 4 ± 7 −42 ± 26 ‡ 4 ± 8 −40 ± 25 ‡ −14 ± 14 ‡ −13 ± 16 ‡ Amygdala 2 ± 15 −20 ± 20 ∗ −4 ± 12 −17 ± 19 ∗ −10 ± 14 § −9 ± 14 Frontal 3 ± 4 1 ± 7 4 ± 3 4 ± 15 −2 ± 3 0 ± 9 Parietal 1 ± 5 −2 ± 13 2 ± 4 −3 ± 14 −2 ± 4 −3 ± 5 Insula 1 ± 6 −7 ± 11 ∗ −1 ± 4 −5 ± 14 −6 ± 6 −5 ± 8 Occipital 2 ± 9 −2 ± 6 2 ± 12 −2 ± 11 −2 ± 3 −2 ± 11 ↵* Uncorrected P < 0.05, controls vs. patients, unpaired t test.
↵‡ P < 0.05 after correction for multiple comparisons, controls vs. patients, unpaired t test.
↵‡ P < 0.05 after correction for multiple region comparisons, 18F-FCWAY vs. 18F-FDG in patient group, paired t test.
↵§ Uncorrected P < 0.05, 18F-FCWAY vs. 18F-FDG in patient group, paired t test.
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