Assessment of Diastolic Function Using 16-Frame 99mTc-Sestamibi Gated Myocardial Perfusion SPECT: Normal Values

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FIGURE 1.
Example of a patient’s volume and filling curves over time in 16-frame gated MPS. Numbers in brackets represent exact frame numbers from which parameters are derived. Arrow shows TTPF, defined by time from ES to greatest filling rate in early diastole. Peak filling is normalized to EDV. ED = end diastole; ES = end systole; BPM = beats per minute HR; MFR/3 = mean filling rate over first third of diastole.
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FIGURE 2.
Scatter plots of relationship between PFR and HR (A) and TTPF and HR (B). Dotted line indicates 2-SD threshold. Solid line is regression line. In A, correlation coefficient (r) is 0.514, P = 0.01. In B, TTPF shows no correlation with HR.
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FIGURE 3.
Scatter plots of relationship between PFR and EF (%) (A) and TTPF and EF (%) (B). Dotted line indicates 2-SD threshold. Solid line is regression line. In A, correlation coefficient (r) is 0.529, P = 0.01. In B, TTPF shows no correlation with EF (%).
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FIGURE 4.
Scatter plots of relationship between PFR and age (A) and TTPF and age (B). Dotted line indicates 2-SD threshold. Solid line is regression line. In A, correlation coefficient (r) is −0.348, P = 0.01. In B, TTPF shows no correlation with age.

TABLE 1

Characteristics of Study Population

Characteristic	Derivation group	Validation group	Overall	P value
Males* (%)	41/50 (82)	30/40 (75)	71/90 (79)	NS
Age (y)	53.3 ± 11.4	52.5 ± 10.3	52.9 ± 10.9	NS
Resting HR	62.7 ± 8.2	61.3 ± 8.2	62.1 ± 8.2	NS
Resting SBP	126.0 ± 16.1	130.4 ± 17.2	127.9 ± 16.6	NS
Resting DBP	77.0 ± 8.3	76.8 ± 8.1	76.9 ± 8.1	NS
MPHR (%)	95.6 ± 5.9	94.1 ± 6.1	94.9 ± 6.0	NS
(+) Clinical response	0/50	2/40	2/90	NS
(+) ECG response	2/50	2/40	4/90	NS

↵* Values in parentheses are percentages.
NS = not significant; SBP = systolic blood pressure (mm Hg); DBP = diastolic blood pressure (mm Hg).

TABLE 2

Poststress SFx and DFx Parameters of Study Population

Parameter	Derivation group	Validation group	Overall	P value
HR (bpm)	73.6 ± 8.0	73.8 ± 8.0	73.7 ± 8.0	NS
LVEF (%)	63.0 ± 5.4	64.6 ± 5.8	63.7 ± 5.6	NS
EDV (mL)	104.2 ± 19.7	107.9 ± 21.7	105.9 ± 20.6	NS
ESV (mL)	39.1 ± 11.5	38.9 ± 12.1	39.0 ± 11.7	NS
PFR (EDV/s)	2.55 ± 0.42	2.70 ± 0.50	2.62 ± 0.46	NS
TTPF (ms)	166.4 ± 25.1	162.3 ± 16.5	164.6 ± 21.7	NS

TABLE 3

Parameters Categorized According to Stress-to-Acquisition Time Interval

TABLE 4

Age Differences Between Poststress SFx and DFx Parameters

TABLE 5

Sex Differences Between Poststress QGS Parameters Assessed

Parameter	Men (n = 71)	Women (n = 19)	P value
Age (y)	53.2 ± 10.7	51.8 ± 11.5	NS
HR (bpm)	73.3 ± 7.8	75.0 ± 8.7	NS
LVEF (%)	62.9 ± 5.1	66.8 ± 6.3	<0.01
EDV (mL)	109.7 ± 19.7	91.4 ± 17.2	<0.001
ESV (mL)	41.2 ± 11.1	30.5 ± 10.5	<0.001
PFR (EDV/s)	2.53 ± 0.40	2.95 ± 0.54	<0.001
TTPF (ms)	165.2 ± 23.1	162.3 ± 15.9	NS

TABLE 6

Multivariable Regression Analysis for Prediction of PFR and TTPF

Variable	β-Coefficient	95% CI for β (lower bound − upper bound)	P value
Model for PFR
R = 0.779; R² = 0.607; adjusted R² = 0.589; SEE = 0.296
Age	−0.405	(−0.023) − (−0.011)	<0.001
Male sex	−0.188	(−0.372) − (−0.051)	<0.05
LVEF	0.484	(0.027) − (0.053)	<0.001
HR	0.274	(0.007) − (0.024)	<0.001
Model for TTPF
R = 0.120; R² = 0.014; adjusted R² = −0.032; SEE = 22.059
Age	0.059	(−0.344) − (0.581)	0.613
Male sex	0.057	(8.958) − (14.946)	0.620
LVEF	0.041	(−0.808) − (1.130)	0.742
HR	−0.074	(−0.843) − (0.438)	0.531