OtherBasic Science Investigations

Biodistribution and Radiation Dosimetry of 11C-WAY100,635 in Humans

Ramin V. Parsey, Marie-Jose Belanger, Gregory M. Sullivan, Norman R. Simpson, Michael G. Stabin, Ronald Van Heertum and J. John Mann
Journal of Nuclear Medicine April 2005, 46 (4) 614-619;

Article Figures & Data

Figures

  • FIGURE 1.
    FIGURE 1.

    Representative whole-body scan of a woman after bolus injection of 11C-WAY100,635. Acquisitions from frame 1 (0–6 min) (A and E), frame 2 (10–16 min) (B and F), frame 3 (20–30 min) (C and G), and frame 5 (56–72 min) (D and H) in coronal (A–D) and transaxial (E–H) planes sometimes spanned 2 bed positions (D). Time–activity curves were obtained for each ROI at each bed position.

  • FIGURE 2.
    FIGURE 2.

    Time–activity curves generated from ROIs shown in Figure 1. Initial fast distribution of radiotracer throughout most of the body, with slower accumulation in kidneys, is followed by accumulation in urinary bladder, suggesting that major route of elimination is urinary system. Solid circles indicate activity in ROI as percentage of injected dose. Area under curve is determined by trapezoidal integration of first 3 time points through origin and integration of single exponential fit through final 3 time points. Time points are different in different organs as organs occupy different bed positions. Solid squares and dashed lines indicate decay-corrected time–activity curve.

  • FIGURE 3.
    FIGURE 3.

    Comparison of radiation dose estimate from in vivo human PET studies and ex vivo rat biodistribution and dosimetry studies with all data points (A) and without urinary bladder and kidneys (B). Solid line in both plots is identity.

Tables

  • TABLE 1

    Individual and Mean Residence Times for 11C-WAY100,635

    RegionMale 1Male 2Male 3Female 1Female 2Female 3Male average (±SD)Female average (±SD)Total average (±SD)*
    Urinary bladder2.63E−012.20E−012.60E−012.71E−012.25E−012.13E−012.48E−01 ± 2.41E−022.36E−01 ± 3.08E−022.42E−01 ± 2.55E−02
    Kidneys3.92E−023.49E−023.72E−022.43E−024.10E−024.25E−023.71E−02 ± 2.15E−033.59E−02 ± 1.01E−023.65E−02 ± 6.56E−03
    Liver2.78E−023.57E−023.66E−023.47E−023.57E−023.57E−023.33E−02 ± 4.86E−033.54E−02 ± 5.70E−043.44E−02 ± 3.29E−03
    Brain1.41E−021.06E−021.13E−021.26E−022.26E−021.39E−021.20E−02 ± 1.87E−031.64E−02 ± 5.46E−031.42E−02 ± 4.36E−03
    Lungs1.48E−021.36E−026.72E−031.25E−021.96E−028.20E−031.17E−02 ± 4.37E−031.35E−02 ± 5.76E−031.26E−02 ± 4.67E−03
    Heart7.60E−036.26E−039.21E−036.56E−031.32E−028.23E−037.69E−03 ± 1.48E−039.32E−03 ± 3.45E−038.51E−03 ± 2.53E−03
    Spleen3.62E−031.85E−032.37E−032.12E−033.86E−031.27E−032.61E−03 ± 9.07E−042.42E−03 ± 1.32E−032.52E−03 ± 1.02E−03
    Stomach wall7.99E−042.40E−032.13E−031.51E−032.88E−034.40E−031.78E−03 ± 8.58E−042.93E−03 ± 1.45E−032.35E−03 ± 1.24E−03
    Gallbladder1.78E−041.02E−032.32E−049.25E−042.23E−042.52E−044.77E−04 ± 4.72E−044.67E−04 ± 3.97E−044.72E−04 ± 3.90E−04

    • ↵* Descending order.

    • Data are in hours.

  • TABLE 2

    Mean Radiation Absorbed Dose Estimates for 11C-WAY100,635

    RegionMale average (±SD)Female average (±SD)Total average (±SD)*
    Urinary bladder wall1.67E−01 ± 1.59E−022.20E−01 ± 2.87E−021.94E−01 ± 3.57E−02
    Kidneys3.39E−02 ± 1.85E−033.57E−02 ± 9.76E−033.48E−02 ± 6.36E−03
    Uterus9.81E−03 ± 9.48E−049.81E−03 ± 9.48E−04
    Liver6.38E−03 ± 8.12E−048.86E−03 ± 2.51E−047.62E−03 ± 1.46E−03
    Spleen5.16E−03 ± 1.31E−035.98E−03 ± 2.37E−035.57E−03 ± 1.77E−03
    Ovaries5.52E−03 ± 3.84E−045.52E−03 ± 3.84E−04
    Lower large intestine wall4.56E−03 ± 1.62E−045.68E−03 ± 4.20E−045.12E−03 ± 6.78E−04
    Lungs3.65E−03 ± 1.09E−035.26E−03 ± 1.84E−034.46E−03 ± 1.61E−03
    Heart wall3.54E−03 ± 3.65E−044.82E−03 ± 1.32E−034.18E−03 ± 1.11E−03
    Brain2.88E−03 ± 4.07E−044.49E−03 ± 1.42E−033.69E−03 ± 1.28E−03
    Stomach wall2.34E−03 ± 9.75E−044.75E−03 ± 2.17E−033.55E−03 ± 2.00E−03
    Gallbladder wall3.23E−03 ± 1.22E−033.80E−03 ± 8.74E−043.52E−03 ± 9.98E−04
    Testes3.19E−03 ± 7.23E−053.19E−03 ± 7.23E−05
    Small intestine2.65E−03 ± 5.13E−053.38E−03 ± 1.17E−043.02E−03 ± 4.08E−04
    Upper large intestine wall2.37E−03 ± 9.17E−053.10E−03 ± 1.31E−042.74E−03 ± 4.14E−04
    Adrenals2.26E−03 ± 1.38E−042.95E−03 ± 3.97E−042.61E−03 ± 4.59E−04
    Pancreas2.13E−03 ± 1.53E−042.69E−03 ± 3.32E−042.41E−03 ± 3.85E−04
    Muscle1.95E−03 ± 7.00E−052.40E−03 ± 8.62E−052.17E−03 ± 2.55E−04
    Red marrow1.82E−03 ± 9.54E−052.33E−03 ± 1.29E−042.07E−03 ± 2.95E−04
    Bone surfaces1.50E−03 ± 1.30E−041.94E−03 ± 1.47E−041.72E−03 ± 2.71E−04
    Thymus1.22E−03 ± 1.39E−041.61E−03 ± 1.74E−041.41E−03 ± 2.54E−04
    Skin1.15E−03 ± 9.87E−051.43E−03 ± 1.10E−041.29E−03 ± 1.83E−04
    Breasts9.85E−04 ± 1.34E−041.31E−03 ± 1.31E−041.15E−03 ± 2.12E−04
    Thyroid9.88E−04 ± 1.57E−041.19E−03 ± 1.50E−041.09E−03 ± 1.77E−04
    Total body2.31E−03 ± 5.20E−052.99E−03 ± 8.19E−052.65E−03 ± 3.77E−04
    Effective dose equivalent1.52E−02 ± 1.10E−031.95E−02 ± 1.25E−031.74E−02 ± 2.56E−03
    Effective dose1.22E−02 ± 7.57E−041.60E−02 ± 1.43E−031.41E−02 ± 2.35E−03

    • ↵* Descending order.

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