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OtherClinical Investigations

Detection and Localization of Prostate Cancer: Correlation of 11C-Choline PET/CT with Histopathologic Step-Section Analysis

Mohsen Farsad, Riccardo Schiavina, Paolo Castellucci, Cristina Nanni, Barbara Corti, Giuseppe Martorana, Romeo Canini, Walter Grigioni, Stefano Boschi, Mario Marengo, Cinzia Pettinato, Eugenio Salizzoni, Nino Monetti, Roberto Franchi and Stefano Fanti
Journal of Nuclear Medicine October 2005, 46 (10) 1642-1649;
Mohsen Farsad
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Riccardo Schiavina
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Paolo Castellucci
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Cristina Nanni
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Barbara Corti
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Giuseppe Martorana
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Romeo Canini
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Walter Grigioni
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Stefano Boschi
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Mario Marengo
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Cinzia Pettinato
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Eugenio Salizzoni
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Nino Monetti
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Roberto Franchi
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Stefano Fanti
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  • FIGURE 1.
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    FIGURE 1.

    PET/CT results and histologic matching.

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    FIGURE 2.

    Patient 6: Coronal PET images show 2 foci of pathologic uptake in left and right mid regions (arrows), confirmed to be the only foci of cancer on histologic examination.

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    FIGURE 3.

    Correlation between SUVmax and lesion type.

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    FIGURE 4.

    Patient 36: Transaxial PET/CT images show 1 focus of pathologic uptake in anterior transitional zone (arrow). First biopsy failed to detect cancer foci, whereas repeated biopsy using PET/CT images detected sites of cancer.

Tables

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    TABLE 1

    Clinical Characteristics of Patients with Prostate Cancer

    Patient no.Age (y)PSA (ng/mL)Free-to-total PSADREHypoechogenic lesion on TRUSProstate volume (cm3)No. of biopsy coresTreatmentTNMGleason score
    165911−+7014RRPT2c N0Gs4+3
    260315++3012RRPT3a N0Gs3+4
    3566.412−−2513VLRPT3a N0Gs3+3
    460913−−7510VLRPT2c N0Gs3+4
    565159−−4512RRPT2c N0Gs3+3
    663520−−5012VLRPT2c N0Gs1+1
    761528−+7512RRPT3a N0Gs4+3
    8571311−−6012VLRPT3a N0Gs3+3
    96427−−2512VLRPT2a N0Gs2+1
    106992++3513RRPT3a N0Gs3+3
    116897−−5012RRPT2c N0Gs3+3
    12702813−−5018RRPT2c N0Gs3+3
    1357812−−5012VLRPT2c N0Gs2+3
    146278−−3515RRPT2c N0Gs3+1
    15511011++4012VLRPT3a N0Gs3+3
    167587++4012RRPT2c N1Gs3+3
    17721020++5512RRPT2c N0Gs2+3
    18642116−+3512VLRPT3a N0Gs3+4
    195859−+5012RRPT3a N0Gs3+3
    2072108++3012VLRPT3a N0Gs4+3
    21682013++2010RRPT3a N0Gs3+3
    226089−−3012RRPT3a N0Gs3+2
    2363519++4015VLRPT2b N0Gs3+3
    24727018++5010RRPT3b N1Gs4+3
    2563713++3010RRPT3b N1Gs4+3
    2659127−−5012VLRPT2c N0Gs3+3
    27705915−+7014RRPT2c N0Gs3+2
    286557−−5013RRPT3a N0Gs3+3
    296056−−3012RRPT2c N0Gs3+3
    306879−−3012RRPT2c N0Gs3+3
    315857++2512RRPT3b N0Gs4+3
    32511211++5012RRPT3b N1Gs4+3
    33696.210−−5012RRPT2c N0Gs2+2
    34711713−−3015RRPT3a N0Gs3+3
    3565712++4012RRPT3a N0Gs3+3
    36525.28−−4012RRPT2c N0Gs3+3
    • RRP = radical retropubic prostatectomy; VLRP = videolaparoscopic prostatectomy.

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    TABLE 2

    Clinical Characteristics of Control Group with Infiltrating Transitional Bladder Carcinoma

    Patient no.Age (y)PSA (ng/mL)Free-to-total PSADRETRUSProstate volume (cm3)TNM (bladder)Tumor grade
    1652.118−−30T1 N02–3
    2702.824−−40T3b N03
    3652.020−−30T1 N03
    4641.330−−45T1 N03
    5711.625−−40T3b N03
    • View popup
    TABLE 3

    Biopsy, PET, and Histologic Results on Sextant Basis

    Patient no.BiopsyPET SUVmaxBackground SUVCarcinomaHGPIN
    1La, LmRm, 4.9; La, 42.5Ra, Rm, La, Lm
    2Ra, Rm, Rb, La, Lm, LbRa, 2.9; Rm, 2.9; La, 2.51.5Ra, Rm, Rb, La, Lm, Lb
    3LbRm, 8.4; Lm, 6.1; Lb, 6.14.0Lm, LbRm, Rb
    4RmRa, 3.3; Rm, 32.0Ra, Rm, La, LbRm, Rb, Lm, Lb
    5Ra, RbRa, 5.4; Rm, 8.1; Rb, 8.1; Lm, 4.3; Lb, 4.52.9Ra, Rm, Rb, La, Lm, LbLb
    6LmRm, 7.4; Lm, 6.43.0Rm, LmRm, Lm
    7Lm, LbRm, 4.9; Rb, 5.72.0Lm, LbRm, Rb, Lm, Lb
    8Rb, Rm, Lm, LbRm, 4.3; Rb, 5.3; La, 4.4; Lm, 4.2; Lb, 4.52.5Rm, Rb, La, Lm, LbRm, Rb, Lb
    9RmRm, 4.6; Rb, 4.62.4Rm, RbRb, Lb
    10RbRm, 6.4; Rb, 5.5; Lm, 52.7Rm, RbLm, Lb
    11RmRm, 2.9; Lm, 2.81.8Rm, Lm
    12Rm,* Lm*Ra, 8.4; Rm, 8.4; Rb, 8.4; Lm, 7.8; Lb, 7.82.5Ra, Rm, Rb, Lm, Lb
    13RbRm, 5.5; Rb, 5.53.0Rm, Rb, LbRm, Rb, Lm, Lb
    14La, LmRm, 4; Lm, 4.72.8Ra, La, Lm, LbRm, Rb, Lm, Lb
    15Ra, RmRa, 4.3; La, 4.32.5Ra, Rm, LaRm
    16Lm, LbRm, 3; Lm, 3; Lb, 3.22.0Rm, Lm, LbRm, Rb, Lm, Lb
    17La, LbRm, 4.9; Rb, 4.9; Lm, 4.9; Lb, 4.92.5Rm, Rb, Lm, LbRm, Rb, Lm, Lb
    18RmRm, 4.1; Rb, 4.42.3Ra, Rm, RbRm, Lb
    19La, LmRm, 2.8; La, 3; Lm, 3; Lb, 3.11.9Rm, La, Lm, LbRa, Rm, Rb, La, Lm, Lb
    20Ra, Rm, Rb, LbRa, 2.7; Rm, 2.7; Rb, 2.81.4Ra, Rm, Rb, LbRm, Rb, Lm, Lb
    21Rm, Rb, LbRa, 4.9; Lm, 7; Lb, 73.0Ra, Rm, Rb, La, Lm, LbRm, Rb, Lm, Lb
    22La, Lm, LbRb, 4.3; Lm, 5; Lb, 52.3La, Lm, LbRm, Rb
    23Lm, LbRm, 4.52.2La, Lm, LbRm, Lm, Lb
    24Ra, Rm, Rb, La, Lm, LbRm, 7; Rb, 7; Lm, 5.93.3Ra, Rm, Rb, La, Lm, Lb
    25Rm, Rb, La, Lm, LbLm, 4.1; Lb, 3.22.0Ra, Rm, Rb, La, Lm, Lb
    26LaRa, 4.6; La, 5.7; Lm, 52.4Ra, Rm, La, Lm, LbLb
    27Rm, LmRm, 7.8; Rb, 7.8; La, 5.7; Lm, 5.73.0Ra, Rm, Rb, La, Lm, LbRa, La, Lb
    28Lm, LbRa, 12; Rm, 12; Rb, 12; La, 10; Lm, 10; Lb, 105.0Lm, LbRm, Rb, La, Lm, Lb
    29Ra, Rb, La, Lm, LbRb, 2.2; Lb, 2.21.6Ra, Rb, Lm, LbRm, La, Lm
    30Rm, Lm, LbLm, 2.21.1Rm, Lm, LbRm, Rb, Lm, Lb
    31Ra, Rm, La, LmRm, 5.8; Lm, 8.5; Lb, 8.52.8Ra, Rm, La, Lm, Lb
    32Ra, Rm, Rb, La, Lm, LbRb, 3.3; Lm, 2.92.0Ra, Rm, Rb, La, Lm, LbRb
    33Lm, LbRa, 5.3; Rm, 5.3; La, 5.3; Lm, 5.3; Lb, 5.33.0Ra, Rm, Rb, Lm, LbRb, Lb
    34Ra,* Rm,* La,* Lm*Ra, 4; Rm, 6.6; La, 6.6; Lm, 42.0Ra, Rm, La, Lm, Lb
    35Rm, Lm, LbRm, 5.6; Rb, 5.4; Lm, 6.9; Lb, 6.22.8Rm, La, LbRa, Rm, Rb, La, Lm, Lb
    36Rb,* La,* Lm,* Lb*Rb, 4.6; La, 3.2; Lm, 4; Lb, 4.62.2Rb, La, Lm, LbRa, Rm, Rb, La, Lm, Lb
    • ↵* Positive on repeated biopsy.

    • La = left apex; Lb = left base; Lm = left middle; Ra = right apex; Rb = right base; Rm = right middle.

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Journal of Nuclear Medicine: 46 (10)
Journal of Nuclear Medicine
Vol. 46, Issue 10
October 1, 2005
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Detection and Localization of Prostate Cancer: Correlation of 11C-Choline PET/CT with Histopathologic Step-Section Analysis
Mohsen Farsad, Riccardo Schiavina, Paolo Castellucci, Cristina Nanni, Barbara Corti, Giuseppe Martorana, Romeo Canini, Walter Grigioni, Stefano Boschi, Mario Marengo, Cinzia Pettinato, Eugenio Salizzoni, Nino Monetti, Roberto Franchi, Stefano Fanti
Journal of Nuclear Medicine Oct 2005, 46 (10) 1642-1649;

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Detection and Localization of Prostate Cancer: Correlation of 11C-Choline PET/CT with Histopathologic Step-Section Analysis
Mohsen Farsad, Riccardo Schiavina, Paolo Castellucci, Cristina Nanni, Barbara Corti, Giuseppe Martorana, Romeo Canini, Walter Grigioni, Stefano Boschi, Mario Marengo, Cinzia Pettinato, Eugenio Salizzoni, Nino Monetti, Roberto Franchi, Stefano Fanti
Journal of Nuclear Medicine Oct 2005, 46 (10) 1642-1649;
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