Article Figures & Data
Figures
- FIGURE 1.
Time dependence of 125I− uptake in wild-type rat thyroid carcinoma cells and in the hNIS-expressing cell line L2hNIShyg3. Values are mean and SD (n = 3).
- FIGURE 2.
Effect of DIDS, FCCP, sodium perchlorate (SP), and ouabain (ouab) on 125I− uptake in wild-type rat thyroid carcinoma cells and in the hNIS-expressing cell line L2hNIShyg3 after 1 h of incubation. Values are mean and SD (n = 3). con = control.
- FIGURE 3.
Iodide efflux from L2hNIShyg3 cells after 1 h of incubation with Na125I with and without 300 μmol of DIDS per liter. Values are mean and SD (n = 3).
- FIGURE 4.
Scintigraphic images of tumor-bearing nude mice with subcutaneously transplanted hNIS-expressing (right thigh) or wild-type (left thigh) thyroid carcinoma cells at 2 h (A), 6 h (B), 24 h (C), and 48 h (D) after injection of 131I−.
- FIGURE 5.
131I− uptake (kBq/g) in hNIS-expressing and wild-type thyroid carcinomas after administration of 1,650 MBq/m2 at different times after radiotracer application in rats. Values are mean and SDs (n = 4).
Tables
- TABLE 1
Iodide Activity Concentration in Animals Treated with Lithium Carbonate at Different Times After Injection of 131I
Tissue Hours after injection 2 6 24 48 Brain 0.11 ± 0.009 0.09 ± 0.04 0.03 ± 0.01 0.005 ± 0.004 Stomach 8.79 ± 1.06 6.82 ± 2.96 2.82 ± 0.66 0.77 ± 0.62 Bowel 1.57 ± 0.29 0.91 ± 0.39 0.24 ± 0.05 0.013 ± 0.003 Liver 0.71 ± 0.13 0.47 ± 0.13 0.14 ± 0.02 0.014 ± 0.002 Spleen 0.84 ± 0.17 0.55 ± 0.18 0.15 ± 0.03 0.011 ± 0.003 Kidney 1.45 ± 0.31 0.78 ± 0.27 0.21 ± 0.03 0.012 ± 0.005 Muscle 0.54 ± 0.06 0.40 ± 0.19 0.08 ± 0.01 0.006 ± 0.002 Heart 1.00 ± 0.14 0.89 ± 0.48 0.15 ± 0.04 0.013 ± 0.008 Lung 1.40 ± 0.24 0.91 ± 0.27 0.25 ± 0.05 0.02 ± 0.007 Tumor weight 1.02 ± 0.31 0.62 ± 0.28 0.18 ± 0.03 0.02 ± 0.004 hNIS tumor weight 23.37 ± 4.90 17.05 ± 4.61 4.09 ± 0.38 0.52 ± 0.30 Values are mean and SD (n = 4) percentage injected dose per gram of tissue.
- TABLE 2
Iodide Activity Concentration in Animals Treated with Sodium Chloride at Different Times After Injection of 131I
Tissue Hours after injection 2 6 24 48 Brain 0.12 ± 0.01 0.11 ± 0.03 0.03 ± 0.02 0.001 ± 0.0004 Stomach 21.37 ± 2.26 11.32 ± 2.96 3.08 ± 1.25 0.32 ± 0.04 Bowel 1.24 ± 0.17 1.09 ± 0.39 0.21 ± 0.08 0.03 ± 0.003 Liver 0.83 ± 0.07 0.54 ± 0.13 0.12 ± 0.05 0.02 ± 0.002 Spleen 1.04 ± 0.04 0.68 ± 0.18 0.12 ± 0.04 0.02 ± 0.002 Kidney 1.52 ± 0.11 0.97 ± 0.27 0.20 ± 0.08 0.02 ± 0.003 Muscle 0.60 ± 0.08 0.45 ± 0.19 0.10 ± 0.04 0.02 ± 0.007 Heart 1.32 ± 0.18 0.67 ± 0.48 0.14 ± 0.05 0.04 ± 0.01 Lung 1.93 ± 0.12 1.08 ± 0.27 0.25 ± 0.10 0.03 ± 0.004 Tumor weight 1.16 ± 0.10 0.82 ± 0.50 0.16 ± 0.06 0.02 ± 0.002 hNIS tumor weight 21.48 ± 2.61 16.04 ± 4.61 4.22 ± 2.2 0.35 ± 0.006 Values are mean and SD (n = 4) percentage injected dose per gram of tissue.
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