Accuracy of a Method Using Short Inhalation of 15O-O2 for Measuring Cerebral Oxygen Extraction Fraction with PET in Healthy Humans

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FIGURE 1.
Example of parametric images. Parametric images of CBV (top left) and CBF (top right) were used to generate OEF image (bottom left). Parametric image for CMRO₂ (bottom right) was generated by applying the following formula to each pixel: CMRO₂ = CaO₂ × OEF × CBF.
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FIGURE 2.
(A) Agreement of OEFpet and OEFav. The cross-line indicates the mean value for OEFpet and OEFav. (B) Bland-Altman plot of the same data.

TABLE 1

Results of PET and Arteriovenous Measurements

Patient no.	PET measurements
Patient no.		CBV (mL/g)	CBF (mL/g/min)	CMRO₂ (mL/100 g/min)	OEF (ratio)	PaCO₂ (mm Hg)	OEF (ratio)	PaCO₂ (mm Hg)
1	0.04	0.45	2.47	0.38	42	0.33	42
2	0.05	0.54	2.81	0.33	35	0.38	35
3	0.05	0.37	2.94	0.31	45	0.31	42
4	0.05	0.37	2.75	0.41	40	0.41	40
5	0.05	0.38	2.83	0.41	42	0.34	42
6	0.05	0.37	3.35	0.46	37	0.42	37
7	0.04	0.39	2.35	0.31	43	0.39	39
8	0.05	0.45	2.56	0.33	43	0.32	42
9	0.09	0.42	3.13	0.41	43	0.34	46
10	0.05	0.45	3.84	0.51	42	0.33	46
11	0.04	0.35	2.95	0.43	36	0.29	36
12	0.07	0.41	2.72	0.37	41	0.41	41
13	0.07	0.39	2.35	0.30	45	0.46	36
14	0.05	0.42	3.19	0.39	40	0.34	41
15	0.05	0.30	2.50	0.44	47	0.34	47
16	0.05	0.39	2.91	0.40	40	0.37	40