Skip to main content

Main menu

  • Home
  • Content
    • Current
    • Ahead of print
    • Past Issues
    • JNM Supplement
    • SNMMI Annual Meeting Abstracts
    • Continuing Education
    • JNM Podcasts
  • Subscriptions
    • Subscribers
    • Institutional and Non-member
    • Rates
    • Journal Claims
    • Corporate & Special Sales
  • Authors
    • Submit to JNM
    • Information for Authors
    • Assignment of Copyright
    • AQARA requirements
  • Info
    • Reviewers
    • Permissions
    • Advertisers
  • About
    • About Us
    • Editorial Board
    • Contact Information
  • More
    • Alerts
    • Feedback
    • Help
    • SNMMI Journals
  • SNMMI
    • JNM
    • JNMT
    • SNMMI Journals
    • SNMMI

User menu

  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Nuclear Medicine
  • SNMMI
    • JNM
    • JNMT
    • SNMMI Journals
    • SNMMI
  • Subscribe
  • My alerts
  • Log in
  • My Cart
Journal of Nuclear Medicine

Advanced Search

  • Home
  • Content
    • Current
    • Ahead of print
    • Past Issues
    • JNM Supplement
    • SNMMI Annual Meeting Abstracts
    • Continuing Education
    • JNM Podcasts
  • Subscriptions
    • Subscribers
    • Institutional and Non-member
    • Rates
    • Journal Claims
    • Corporate & Special Sales
  • Authors
    • Submit to JNM
    • Information for Authors
    • Assignment of Copyright
    • AQARA requirements
  • Info
    • Reviewers
    • Permissions
    • Advertisers
  • About
    • About Us
    • Editorial Board
    • Contact Information
  • More
    • Alerts
    • Feedback
    • Help
    • SNMMI Journals
  • View or Listen to JNM Podcast
  • Visit JNM on Facebook
  • Join JNM on LinkedIn
  • Follow JNM on Twitter
  • Subscribe to our RSS feeds
OtherClinical Investigations

Loss of Dopamine Transporter Binding in Parkinson’s Disease Follows a Single Exponential Rather Than Linear Decline

Johannes Schwarz, Alexander Storch, Walter Koch, Oliver Pogarell, Perry E. Radau and Klaus Tatsch
Journal of Nuclear Medicine October 2004, 45 (10) 1694-1697;
Johannes Schwarz
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Alexander Storch
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Walter Koch
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Oliver Pogarell
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Perry E. Radau
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Klaus Tatsch
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Article Figures & Data

Figures

  • Tables
  • FIGURE 1.
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIGURE 1.

    In patients with PD, data on 7.5-y follow-up of striatal DAT binding. Data are best fitted by a single exponential decay (solid line). Extrapolation of calculated single exponential decline hits control values 4–5 y before the first scan (dashed line). The 3 initial patient scans are well fitted by a linear decline (dotted line).

Tables

  • Figures
    • View popup
    TABLE 1

    Uptake Ratios, Time Constants, and Correlation Coefficients Using a Single Exponential Decay Fit

    Region0 y1 y2 y7.5 y1/τ (y)R2
    Striatum1.65 ± 0.141.50 ± 0.191.31 ± 0.140.78 ± 0.106.65 ± 10.250.9992
    Putamen1.22 ± 0.161.10 ± 0.170.94 ± 0.120.56 ± 0.085.18 ± 7.620.9986
    Caudate2.03 ± 0.181.87 ± 0.261.66 ± 0.210.96 ± 0.1410.62 ± 31.40.9995
PreviousNext
Back to top

In this issue

Journal of Nuclear Medicine: 45 (10)
Journal of Nuclear Medicine
Vol. 45, Issue 10
October 1, 2004
  • Table of Contents
  • About the Cover
  • Index by author
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on Journal of Nuclear Medicine.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Loss of Dopamine Transporter Binding in Parkinson’s Disease Follows a Single Exponential Rather Than Linear Decline
(Your Name) has sent you a message from Journal of Nuclear Medicine
(Your Name) thought you would like to see the Journal of Nuclear Medicine web site.
Citation Tools
Loss of Dopamine Transporter Binding in Parkinson’s Disease Follows a Single Exponential Rather Than Linear Decline
Johannes Schwarz, Alexander Storch, Walter Koch, Oliver Pogarell, Perry E. Radau, Klaus Tatsch
Journal of Nuclear Medicine Oct 2004, 45 (10) 1694-1697;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Loss of Dopamine Transporter Binding in Parkinson’s Disease Follows a Single Exponential Rather Than Linear Decline
Johannes Schwarz, Alexander Storch, Walter Koch, Oliver Pogarell, Perry E. Radau, Klaus Tatsch
Journal of Nuclear Medicine Oct 2004, 45 (10) 1694-1697;
Twitter logo Facebook logo LinkedIn logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Bookmark this article

Jump to section

  • Article
    • Abstract
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • CONCLUSION
    • Acknowledgments
    • Footnotes
    • REFERENCES
  • Figures & Data
  • Info & Metrics
  • PDF

Related Articles

  • THIS MONTH IN JNM
  • PubMed
  • Google Scholar

Cited By...

  • Long-term follow-up study of SWEDD patients with mild parkinsonian signs
  • A Phase II study to evaluate the safety and efficacy of prasinezumab in early Parkinsons disease (PASADENA): rationale, design and baseline data
  • Longitudinal change in dopamine transporter availability in idiopathic REM sleep behavior disorder
  • Effects of dopaminergic treatment on striatal dopamine turnover in de novo Parkinson disease
  • Molecular Imaging of the Dopamine Transporter
  • Extended Studies of the Striatal Uptake of 99mTc-NC100697 in Healthy Volunteers
  • Is Iterative Reconstruction an Alternative to Filtered Backprojection in Routine Processing of Dopamine Transporter SPECT Studies?
  • Google Scholar

More in this TOC Section

  • Feasibility of Ultra-Low-Activity 18F-FDG PET/CT Imaging Using a Long–Axial-Field-of-View PET/CT System
  • Cardiac Presynaptic Sympathetic Nervous Function Evaluated by Cardiac PET in Patients with Chronotropic Incompetence Without Heart Failure
  • Validation and Evaluation of a Vendor-Provided Head Motion Correction Algorithm on the uMI Panorama PET/CT System
Show more Clinical Investigations

Similar Articles

SNMMI

© 2025 SNMMI

Powered by HighWire