Validation of QGS and 4D-MSPECT for Quantification of Left Ventricular Volumes and Ejection Fraction from Gated 18F-FDG PET: Comparison with Cardiac MRI

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FIGURE 1.
Correlation analysis of EDV estimated with QGS (A) and 4D-MSPECT (C) from gated ¹⁸F-FDG PET and cMRI. Bland-Altman plots compare QGS versus cMRI (B) and 4D-MSPECT versus cMRI (D). 4DM = 4D-MSPECT; gFDG-PET and gPET = gated ¹⁸F-FDG PET.
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FIGURE 2.
Correlation analysis of ESV estimated with QGS (A) and 4D-MSPECT (C) from gated ¹⁸F-FDG PET and cMRI. Bland-Altman plots compare QGS versus cMRI (B) and 4D-MSPECT versus cMRI (D). 4DM = 4D-MSPECT; gFDG-PET and gPET = gated ¹⁸F-FDG PET.
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FIGURE 3.
Correlation analysis of LVEF estimated with QGS (A) and 4D-MSPECT (C) from gated ¹⁸F-FDG PET and cMRI. Bland-Altman plots compare QGS versus cMRI (B) and 4D-MSPECT versus cMRI (D). 4DM = 4D-MSPECT; gFDG-PET and gPET = gated ¹⁸F-FDG PET.
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FIGURE 4.
Correlation analysis of EDV (A), ESV (C), and LVEF (E) estimated with QGS and 4D-MSPECT from gated ¹⁸F-FDG PET. Bland-Altman plots compare QGS versus 4D-MSPECT for EDV (B), ESV (D), and LVEF (F). 4DM = 4D-MSPECT; gFDG-PET = gated ¹⁸F-FDG PET.

TABLE 1

Values of EDV, ESV, and LVEF from cMRI and Gated ¹⁸F-FDG PET

Value (n = 42)	EDV (mL)					ESV (mL)
Value (n = 42)		cMRI	4D-MSPECT	QGS	cMRI	4D-MSPECT	QGS	cMRI	4D-MSPECT	QGS
Mean ± SD	176 ± 53	178 ± 58	177 ± 56	118 ± 50	121 ± 52	126 ± 52	34.9 ± 10.7	33.8 ± 8.7	30.6 ± 7.6
Range	87–328	85–344	87–345	42–247	52–281	59–271	12–59	18–53	16–47
P vs. cMRI		NS	NS		NS	NS		NS	<0.0001