Relationship Between 18F-FDG Uptake and Breast Density in Women with Normal Breast Tissue

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FIGURE 1.
Average SUV (A) and peak SUV (B) plotted for different breast-density groups. Data are presented separately for left and right breasts. Entirely fatty breasts had lowest SUVs.
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FIGURE 2.
Average SUV (A) and peak SUV (B) as function of age. Linear regression lines are given separately for left and right breasts. No regression slopes differed significantly from horizontal (slope = 0). Age does not appear to be a factor in normal breast glycolytic activity.
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FIGURE 3.
Scattergrams of uncorrected SUV of normal breast tissue versus SUV corrected for lean body mass (LBM) (A) or body surface area (BSA) (B). Note high correlation coefficients.
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FIGURE 4.
Typical breasts in the 3 density categories. Transverse slices of dense (A), primarily fatty (B), and entirely fatty (C) breasts are shown. Region of areola has increased uptake relative to remainder of breast. Note decreasing ¹⁸F-FDG uptake from A to B, with clear photopenia in area of entirely fatty breasts (C).

TABLE 1

Average and Peak SUV for Different Breast-Density and Menopausal-Status Groups

Group	n	Average SUV			Peak SUV
Group	n			Right breast	Left breast	Right breast	Left breast
Dense	21	0.39 ± 0.05	0.36 ± 0.07	0.93 ± 0.16	0.89 ± 0.18
Primarily fatty	20	0.32 ± 0.10	0.31 ± 0.08	0.80 ± 0.22	0.75 ± 0.20
Entirely fatty	4	0.22 ± 0.07	0.22 ± 0.09	0.51 ± 0.06	0.53 ± 0.13
Premenopausal	12	0.34 ± 0.08	0.35 ± 0.09	0.98 ± 0.27	0.91 ± 0.24
Postmenopausal (no HRT)	12	0.28 ± 0.06	0.31 ± 0.08	0.76 ± 0.17	0.71 ± 0.14
Postmenopausal (HRT)	12	0.37 ± 0.10	0.36 ± 0.05	0.85 ± 0.20	0.84 ± 0.22