Article Figures & Data
Figures
- FIGURE 1.
Representative transverse 99mTc-TRODAT-1 SPECT images (A) and concordant 18F-FDOPA PET images (B) of healthy volunteer. Bilateral, symmetrically normal uptake in striatum is seen on both SPECT and PET.
- FIGURE 2.
Representative transverse 99mTc-TRODAT-1 SPECT images (A) and concordant 18F-FDOPA PET images (B) of patient with HYS II PD (patient 16). Markedly decreased uptake in right putamen, with less apparent decrease in left putamen, was found on both SPECT and PET.
- FIGURE 3.
Transverse 99mTc-TRODAT-1 SPECT images (A) and discordant 18F-FDOPA PET images (B) of patient with HYS I PD (patient 1). SPECT images showed greater loss of uptake in left putamen and appeared more correlated with clinical manifestations than did corresponding 18F-FDOPA PET images.
- FIGURE 4.
Transverse 99mTc-TRODAT-1 SPECT images (A) and discordant 18F-FDOPA PET images (B) of patient with HYS II PD (patient 15). PET images correlated better with clinical staging than did corresponding 99mTc-TRODAT-1 SPECT images, which appeared to overestimate disease severity.
- FIGURE 5.
Correlation of 99mTc-TRODAT-1 SPECT and 18F-FDOPA PET in striatum as measured by SURs. Straight line is linear regression line. Each point represents an individual striatum. ○ = HYS I; □ = HYS II; ▵ = HYS III; • = HYS IV.
- FIGURE 6.
Correlation of 99mTc-TRODAT-1 SPECT and 18F-FDOPA PET in putamen as measured by SURs. Straight line is linear regression line. Each point represents an individual putamen. ○ = HYS I; □ = HYS II; ▵ = HYS III; • = HYS IV.
Tables
Patient no. Sex Age (y) Disease duration (y) HYS Clinical manifestations Visual inspection SUR PET SPECT ST PU ST PU 18F-FDOPA PET 99mTc-TRODAT-1 SPECT R L R L R L R L 1 M 78 3 I Bradykinesia, tremor, R limbs Mildly decreased uptake in bil. ST Decreased uptake in bil. PU, more on L 1.31 1.36 1.42 1.5 1.63 1.25 1.49 1.04 2 F 48 5 III Rigidity, akinesia, tremor, bil. Decreased uptake in bil. PU, more on R Decreased uptake in bil. PU, more on R 0.70 0.80 0.27 0.35 1.08 1.01 0.75 0.78 3 M 59 8 IV Rigidity, akinesia, tremor, bil. Decreased uptake in bil. ST, more on R Markedly decreased uptake in bil. ST, more on R 0.44 0.47 0.41 0.53 0.37 0.89 0.25 0.65 4 F 66 9 IV Rigidity, akinesia, tremor, bil. No uptake in bil. PU Markedly decreased uptake in bil. ST, more on L 0.61 0.72 0.48 0.58 0.78 0.50 0.74 0.31 5 M 67 12 III Rigidity, akinesia, tremor, bil. Decreased uptake in bil. CA, no uptake in bil. PU Decreased uptake in bil. ST, more on L 0.45 0.40 0.42 0.36 0.97 0.38 0.78 0.51 6 M 66 7 IV Rigidity, akinesia, tremor, bil. Decreased uptake in bil. PU and L CA Decreased uptake in bil. PU and L CA 0.36 0.34 0.41 0.34 1.13 0.86 0.82 0.63 7 M 77 6 III Rigidity, akinesia, tremor, bil. Decreased uptake in bil. ST Decreased uptake in bil. ST, more on R 0.67 0.62 0.76 0.79 0.82 0.98 0.66 0.93 8 M 69 7 II Rigidity, tremor, R > L limbs Decreased uptake in bil. PU, more on L Decreased uptake in bil. PU, more on L 0.50 0.51 0.78 0.72 0.96 0.95 0.67 0.45 9 F 70 5 III Rigidity, tremor, R > L limbs Decreased uptake in bil. ST, more on L Decreased uptake in bil. ST, more on L 0.84 0.73 0.87 0.74 1.17 0.43 1.06 0.02 10 F 67 4 III Rigidity, akinesia, tremor, L > R limbs Decreased uptake in bil. PU, more on R Decreased uptake in bil. PU, more on R 0.72 0.74 0.76 0.82 0.96 1.08 0.16 0.49 11 M 48 5 II Rigidity, tremor, L > R limbs, mask face Decreased uptake in bil. PU, more on R Decreased uptake in bil. ST 0.66 0.86 0.57 0.91 0.90 0.84 0.69 0.61 12 F 53 2 I Rigidity, tremor, R limbs Decreased uptake in bil. PU Decreased uptake in bil. PU 0.94 0.87 0.86 0.65 1.54 1.19 1.34 0.96 13 F 71 6 III Rigidity, akinesia, tremor, L > R limbs Decreased uptake in bil. PU Decreased uptake in bil. PU, more on L 0.56 0.54 0.52 0.64 1.49 1.39 1.18 0.91 14 F 49 3 I Rigidity, tremor, L upper limb Decreased uptake in bil. PU, more on R Decreased uptake in bil. PU, more on R 0.78 1.00 0.76 0.91 1.61 2.15 0.90 1.25 15 F 74 3 II Rigidity, akinesia, tremor, L > R limbs Decreased uptake in bil. PU, more on R Markedly decreased uptake in bil. ST 1.16 1.40 1.11 1.29 0.77 0.53 0.69 0.39 16 M 56 5 II Rigidity, akinesia, tremor, L > R limbs Decreased uptake in bil. PU, more on R Decreased uptake in bil. PU, more on R 0.56 1.03 1.02 1.27 0.93 1.12 0.60 1.04 17 M 70 4 II Bradykinesia, tremor, L > R limbs Decreased uptake in bil. ST Decreased uptake in bil. PU, more on R 1.10 1.05 0.97 1.27 1.39 1.50 0.85 1.04 18 M 76 3 II Akinesia, tremor, R > L limbs Mildly decreased uptake in bil. ST Decreased uptake in bil. PU 1.30 1.24 1.31 1.15 1.48 1.28 1.11 0.96 19 M 65 5 I Akinesia, tremor, R limbs Decreased uptake in L PU Decreased uptake in bil. PU, more on L 1.20 1.03 1.32 1.17 2.06 1.22 1.69 1.24 20 F 52 6 III Rigidity, akinesia, tremor, bil. Decreased uptake in bil. ST Decreased uptake in bil. ST 0.54 0.52 0.48 0.47 1.10 1.02 0.57 0.69 ST = striatum; PU = putamen; CA = caudate; bil. = bilateral.
