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Journal of Nuclear Medicine

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OtherClinical Investigations

Validation of Ultrafiltration as a Method of Measuring Free 99mTc-MDP

Amelia E.B. Moore, Sharon F. Hain, Glen M. Blake and Ignac Fogelman
Journal of Nuclear Medicine June 2003, 44 (6) 891-897;
Amelia E.B. Moore
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Sharon F. Hain
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Glen M. Blake
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Ignac Fogelman
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  • FIGURE 1.
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    FIGURE 1.

    Percentage of free 99mTc-MDP measured using 10-kDa ultrafilter plotted against time after injection for each of 10 volunteers in study 1.

  • FIGURE 2.
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    FIGURE 2.

    Percentage of free 99mTc-MDP measured by ultrafiltration plotted against corresponding measurement derived using GFR method (23,24) for 5-kDa (A), 10-kDa (B), and 30-kDa (C) molecular weight filters. Dashed line shows line of identity.

  • FIGURE 3.
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    FIGURE 3.

    Slope of regression line of ultrafiltration vs. GFR method determined from ultrafiltrate data plotted for 5-, 10-, 30-, 50-, and 100-kDa filters in study 1. Dashed line shows ratio of unity.

  • FIGURE 4.
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    FIGURE 4.

    Percentage of free 99mTc-MDP measured using 10-kDa ultrafilter plotted against time after injection for each of 51 patients in study 2.

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    FIGURE 5.

    Data for mean percentage of free 99mTc-MDP obtained in study 1 and study 2 using 10-kDa ultrafilters are compared with measurements obtained from 49 postmenopausal women by Park-Holohan et al. (23) and Blake et al. (24) using GFR method.

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    TABLE 1

    Demographic Data for Study 1 Population

    ParameterMale (n = 3)Female (n = 7)
    MeanRangeMeanRange
    Age (y)39.732–5435.326–55
    Height (cm)178.9172–183164.7158–176
    Weight (kg)81.0375–8463.450–85
    Body surface area (m2)2.01.9–2.11.71.5–2.0
    GFR (mL/min)111.5103–11894.274–128
    Corrected GFR (mL/min)96.986–10991.376–117
    Albumin (g/L)4241–434341–48
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    TABLE 2

    Demographic Data for Study 2 Population

    ParameterMean ± SDRange
    Age (y)66 ± 13.431–87
    Albumin (g/L)39 ± 2.735–44
    Creatinine (μmol/L)90 ± 22.556–138
    GFR (mL/min)75 ± 19.942–127
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Journal of Nuclear Medicine
Vol. 44, Issue 6
June 1, 2003
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Validation of Ultrafiltration as a Method of Measuring Free 99mTc-MDP
Amelia E.B. Moore, Sharon F. Hain, Glen M. Blake, Ignac Fogelman
Journal of Nuclear Medicine Jun 2003, 44 (6) 891-897;

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Validation of Ultrafiltration as a Method of Measuring Free 99mTc-MDP
Amelia E.B. Moore, Sharon F. Hain, Glen M. Blake, Ignac Fogelman
Journal of Nuclear Medicine Jun 2003, 44 (6) 891-897;
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