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OtherClinical Investigations

Quantitative Measurement of Regional Cerebrovascular Reactivity to Acetazolamide Using 123I-N-Isopropyl-p-Iodoamphetamine Autoradiography with SPECT: Validation Study Using H215O with PET

Kuniaki Ogasawara, Hiroshi Ito, Masayuki Sasoh, Taku Okuguchi, Masakazu Kobayashi, Hirotsugu Yukawa, Kazunori Terasaki and Akira Ogawa
Journal of Nuclear Medicine April 2003, 44 (4) 520-525;
Kuniaki Ogasawara
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Hiroshi Ito
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Masayuki Sasoh
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Taku Okuguchi
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Masakazu Kobayashi
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Hirotsugu Yukawa
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Kazunori Terasaki
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Akira Ogawa
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  • FIGURE 1.
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    FIGURE 1.

    Regions of interest in image slice standardized and summed using 3-dimensional stereotactic surface projections.

  • FIGURE 2.
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    FIGURE 2.

    Correlations of rCBF values calculated by 123I-IMP-ARG method with those calculated by H215O PET method. (A) Resting state. (B) Acetazolamide challenge. Significant correlation was observed in both conditions. Dashed straight line denotes line of identity.

  • FIGURE 3.
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    FIGURE 3.

    Functional rCBF images calculated by 123I-IMP-ARG method and those calculated by H215O PET method. Data were obtained from patient with left ICA occlusion. Same color scale is used to display these 2 quantitative rCBF images. rCBF images obtained by 123I-IMP-ARG method are reduced in high rCBF areas compared with PET images.

  • FIGURE 4.
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    FIGURE 4.

    Correlation of rCVR values calculated by 123I-IMP-ARG method with those calculated by H215O PET method. Significant correlation was observed between these 2 values. Plot of relationship between these 2 values revealed 4 groups of results: (a) those with reduced rCVR (true-positive; ○); (b) those that only H215O PET method identified as reduced rCVR (false-negative; •); (c) those without reduced rCVR (true-negative; ○); and (d) those considered reduced rCVR only by 123I-IMP-ARG method (false-positive; Embedded Image). Dashed horizontal and vertical lines denote mean − 2 SD of rCVR values obtained in healthy volunteers by 123I-IMP-ARG method and by H215O PET method, respectively.

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    TABLE 1

    Physiologic Data of 39 Patients Measured During SPECT and PET at Rest and with Acetazolamide Challenge

    ParameterSPECTPET
    RestACZRestACZ
    pH7.39 ± 0.037.40 ± 0.037.40 ± 0.047.41 ± 0.03
    Paco2 (mm Hg)41.8 ± 3.040.1 ± 2.840.6 ± 2.939.9 ± 3.1
    Pao2 (mm Hg)94.1 ± 2.995.9 ± 4.394.8 ± 3.196.8 ± 4.1
    Mean blood pressure (mm Hg)95.1 ± 8.196.6 ± 8.295.9 ± 7.697.1 ± 9.8
    • ACZ = acetazolamide; Paco2 = arterial carbon dioxide tension; Pao2 = arterial oxygen tension.

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Journal of Nuclear Medicine
Vol. 44, Issue 4
April 1, 2003
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Quantitative Measurement of Regional Cerebrovascular Reactivity to Acetazolamide Using 123I-N-Isopropyl-p-Iodoamphetamine Autoradiography with SPECT: Validation Study Using H215O with PET
Kuniaki Ogasawara, Hiroshi Ito, Masayuki Sasoh, Taku Okuguchi, Masakazu Kobayashi, Hirotsugu Yukawa, Kazunori Terasaki, Akira Ogawa
Journal of Nuclear Medicine Apr 2003, 44 (4) 520-525;

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Quantitative Measurement of Regional Cerebrovascular Reactivity to Acetazolamide Using 123I-N-Isopropyl-p-Iodoamphetamine Autoradiography with SPECT: Validation Study Using H215O with PET
Kuniaki Ogasawara, Hiroshi Ito, Masayuki Sasoh, Taku Okuguchi, Masakazu Kobayashi, Hirotsugu Yukawa, Kazunori Terasaki, Akira Ogawa
Journal of Nuclear Medicine Apr 2003, 44 (4) 520-525;
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  • Oxygen extraction fraction and acetazolamide reactivity in symptomatic carotid artery disease
  • Differences in Vasodilatory Capacity and Changes in Cerebral Blood Flow Induced by Acetazolamide in Patients with Cerebrovascular Disease
  • Qualitative versus Quantitative Assessment of Cerebrovascular Reactivity to Acetazolamide Using iodine-123-N-Isopropyl-p-Iodoamphetamine SPECT in Patients with Unilateral Major Cerebral Artery Occlusive Disease
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