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Journal of Nuclear Medicine

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OtherClinical Investigations

Model-Based Analysis of Electrocardiography-Gated Cardiac 18F-FDG PET Images to Assess Left Ventricular Geometry and Contractile Function

Aliasghar Khorsand, Senta Graf, Herbert Frank, Kurt Kletter, Heinz Sochor, Gerald Maurer, Ernst Schuster, Sebastian Globits, Robert Dudczak and Gerold Porenta
Journal of Nuclear Medicine November 2003, 44 (11) 1741-1746;
Aliasghar Khorsand
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Senta Graf
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Herbert Frank
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Kurt Kletter
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Heinz Sochor
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Gerald Maurer
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Ernst Schuster
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Sebastian Globits
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Robert Dudczak
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Gerold Porenta
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  • FIGURE 1.
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    FIGURE 1.

    (A) Three-dimensional model of left ventricle as used for calculation of volume and mass. (B) One-dimensional model of radial tracer profile originating from center of left ventricle and extending through myocardium into background. Cb = blood-pool activity; Cg = background activity; Cm = myocardial activity; d = wall thickness; h = slice thickness; n = slice number; R = left ventricular radius; z = left ventricular long axis.

  • FIGURE 2.
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    FIGURE 2.

    Example of model-based parameter estimation of cardiac geometry. Short-axis images obtained at basal (left), midventricular (middle), and apical (right) level by MRI (first and fourth rows) and PET (second and fifth rows) for diastolic (top 3 rows) and systolic (bottom 3 rows) time points. Third and sixth rows depict short-axis views with overlay of estimated endocardial and epicardial contours.

  • FIGURE 3.
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    FIGURE 3.

    Example of model-based parameter estimation in patient with large defect in tracer uptake due to myocardial infarction: short-axis (left) and horizontal long-axis (right) images with estimated endocardial and epicardial contours (bottom row).

  • FIGURE 4.
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    FIGURE 4.

    End-systolic (ESV) and end-diastolic (EDV) volumes of left ventricle, ejection fraction (EF), and left ventricular mass (LVM) as obtained from MRI and PET (P = not statistically significant [NS], paired t test).

  • FIGURE 5.
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    FIGURE 5.

    Regression analysis and Bland-Altman plots of end-systolic (ESV) (A and C) and end-diastolic (EDV) (B and D) volumes measured by PET and MRI. Dashed lines in A and B are lines of identity (PET value = MRI value). Mean difference (M) with 95% confidence limits (± 2 SDs) in C and D are presented by solid and dashed lines, respectively.

  • FIGURE 6.
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    FIGURE 6.

    Regression analysis and Bland-Altman plots of ejection fraction (EF) (A and C) and left ventricular mass (LVM) (B and D) measured by PET and MRI. Dashed lines in A and B are lines of identity (PET value = MRI value). Mean difference (M) with 95% confidence limits (± 2 SDs) in C and D are presented by solid and dashed lines, respectively.

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Journal of Nuclear Medicine
Vol. 44, Issue 11
November 1, 2003
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Model-Based Analysis of Electrocardiography-Gated Cardiac 18F-FDG PET Images to Assess Left Ventricular Geometry and Contractile Function
Aliasghar Khorsand, Senta Graf, Herbert Frank, Kurt Kletter, Heinz Sochor, Gerald Maurer, Ernst Schuster, Sebastian Globits, Robert Dudczak, Gerold Porenta
Journal of Nuclear Medicine Nov 2003, 44 (11) 1741-1746;

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Model-Based Analysis of Electrocardiography-Gated Cardiac 18F-FDG PET Images to Assess Left Ventricular Geometry and Contractile Function
Aliasghar Khorsand, Senta Graf, Herbert Frank, Kurt Kletter, Heinz Sochor, Gerald Maurer, Ernst Schuster, Sebastian Globits, Robert Dudczak, Gerold Porenta
Journal of Nuclear Medicine Nov 2003, 44 (11) 1741-1746;
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  • Automatic Extraction of Myocardial Mass and Volume Using Parametric Images from Dynamic Nongated PET
  • Gated Cardiac 13N-NH3 PET for Assessment of Left Ventricular Volumes, Mass, and Ejection Fraction: Comparison with Electrocardiography-Gated 18F-FDG PET
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  • Cardiac Presynaptic Sympathetic Nervous Function Evaluated by Cardiac PET in Patients with Chronotropic Incompetence Without Heart Failure
  • Validation and Evaluation of a Vendor-Provided Head Motion Correction Algorithm on the uMI Panorama PET/CT System
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