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OtherClinical Investigations

Inflammatory Bowel Disease Activity Assessment with Biologic Markers and 99mTc-WBC Scintigraphy: Are There Different Trends in Ileitis Versus Colitis?

Martin Charron
Journal of Nuclear Medicine October 2003, 44 (10) 1586-1591;
Martin Charron
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  • FIGURE 1.
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    FIGURE 1.

    ESR vs. SAI in children with CD.

  • FIGURE 2.
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    FIGURE 2.

    Anterior projection of scintigraphy with 99mTc-WBC of 18 y old with CD that reveals increased uptake in sigmoid, ascending, and descending colon (ESR, 29 mm/h; WBC, 15.5 × 1,000 cells/mm3 μL; Alb, 2.9 g/dL).

  • FIGURE 3.
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    FIGURE 3.

    Anterior projection of scintigraphy with 99mTc-WBC of 11 y old with CD that reveals increased uptake limited to small bowel (ESR, 7 mm/h; WBC, 7.5 × 1,000 cells/mm3 μL; Alb, 4.1 g/dL).

  • FIGURE 4.
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    FIGURE 4.

    Concatenated graph of WBC vs. 99mTc-WBC uptake in terminal ileum, small bowel, ascending colon, transverse colon, descending colon, and sigmoid in children with CD.

Tables

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    TABLE 1

    Pearson Correlation Coefficient (R) and Significance (P) for Laboratory Value vs. Segmental Bowel Uptake of 99mTc-WBC in CD

    ParameterESRWBCHgHtPltAlbPro
    Terminal ileumR−0.029−0.330*−0.100−0.0270.114−0.1410.051
    P0.8520.0170.4760.8480.4500.4180.714
    Small bowelR0.099−0.325*−0.080−0.0200.007−0.325−0.082
    P0.5230.0190.5680.8870.9630.0570.554
    CecumR0.2020.247−0.189−0.0900.300*−0.2870.011
    P0.1900.0770.1750.5110.0430.0950.936
    Ascending colonR0.1600.413†−0.315*−0.2580.459†−0.346*−0.214
    P0.3000.0020.0220.0570.0010.0420.117
    Transverse colonR0.2050.383†−0.237−0.2290.380†−0.170−0.275*
    P0.1810.0050.0880.0930.0090.3280.042
    Descending colonR0.1860.299*−0.114−0.1490.272−0.227−0.454†
    P0.2280.0310.4160.2790.0680.1900.001
    SigmoidR0.2340.400†0.017−0.0260.249−0.069−0.278*
    P0.1260.0030.9030.8480.0940.6930.040
    RectumR0.244−0.043−0.195−0.293*0.0790.2940.154
    P0.1100.7610.1630.0300.6030.0860.260
    SAIR0.314*0.213−0.244−0.2110.343*−0.276−0.198
    P0.0410.1330.0810.1260.0200.1090.151
    • ↵* Correlation is significant at 0.05 level.

    • ↵† Correlation is significant at 0.01 level.

    • View popup
    TABLE 2

    Pearson Correlation Coefficient (R) and Significance (P) for SAI vs. Clinical Activity Indices

    SAIPCDAI (21)Lloyd-Still and Green (22)Van Hees et al. (27)van Wersch et al. (24)Cooke and Prior (28)Kambe et al. (29)
    R0.421*0.427*−0.164−0.0940.1230.105
    P<0.001<0.0010.790.580.4690.537
    • ↵* Correlation is significant at 0.01 level.

    • PCDAI = pediatric CD activity index.

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Journal of Nuclear Medicine
Vol. 44, Issue 10
October 1, 2003
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Inflammatory Bowel Disease Activity Assessment with Biologic Markers and 99mTc-WBC Scintigraphy: Are There Different Trends in Ileitis Versus Colitis?
Martin Charron
Journal of Nuclear Medicine Oct 2003, 44 (10) 1586-1591;

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Inflammatory Bowel Disease Activity Assessment with Biologic Markers and 99mTc-WBC Scintigraphy: Are There Different Trends in Ileitis Versus Colitis?
Martin Charron
Journal of Nuclear Medicine Oct 2003, 44 (10) 1586-1591;
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