PT - JOURNAL ARTICLE AU - Martin Charron TI - Inflammatory Bowel Disease Activity Assessment with Biologic Markers and <sup>99m</sup>Tc-WBC Scintigraphy: Are There Different Trends in Ileitis Versus Colitis? DP - 2003 Oct 01 TA - Journal of Nuclear Medicine PG - 1586--1591 VI - 44 IP - 10 4099 - http://jnm.snmjournals.org/content/44/10/1586.short 4100 - http://jnm.snmjournals.org/content/44/10/1586.full SO - J Nucl Med2003 Oct 01; 44 AB - To evaluate whether scintigraphy with 99mTc-labeled white blood cells (WBC) can assess the intensity of bowel inflammation, a large dataset of laboratory values and clinical activity indices was correlated with 99mTc-WBC scintigraphy in children with Crohn’s disease (CD), ulcerative colitis (UC), and miscellaneous colitis (MC). Also evaluated was whether stratification of children with CD as ileitis versus colitis results in different correlation coefficients for laboratory values versus 99mTc-WBC scintigraphy. Methods: Over a 6-y period, 313 99mTc-WBC studies were performed. A dataset of 2,714 laboratory values is available for analysis. Results: There is a positive correlation between the erythrocyte sedimentation rate (ESR) and large bowel uptake of 99mTc-WBC (P &lt; 0.05) and a negative trend with small bowel uptake of 99mTc-WBC in children with CD. Similarly, there is a correlation between WBC counts and scintigraphy in most segments of the large bowel and a negative correlation with the small bowel (R = −0.32, P = 0.01) in children with CD. There is a correlation between platelets and 99mTc-WBC in children with CD or UC. There is no correlation between the ESR and 99mTc-WBC in children with UC or MC. Many clinical activity indices correlate (P &lt; 0.001) with 99mTc-WBC in children with CD, but none correlates in children with UC. Numerous laboratory values correlate with each other. There is a negative correlation between protein, albumin, hemoglobin, and hematocrit versus 99mTc-WBC scintigraphy in children with CD. In children with UC, there is a negative correlation between hemoglobin and hematocrit versus 99mTc-WBC. Conclusion: 99mTc-WBC scintigraphy, ESR, and WBC counts are good indicators of the inflammatory activity in CD if the inflammation is limited to the large bowel. There is a trend toward an inverse relationship when the inflammation is limited to the small bowel; thus, scintigraphy and the aforementioned markers may be of limited value. This report also demonstrates that 99mTc-WBC scintigraphy correlates with clinical activity indices in CD and with numerous biologic markers. In children with UC, scintigraphy with 99mTc-WBC and most laboratory markers are of limited value in assessing disease activity.