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Comparison of Cardiac Sympathetic Nervous Function with Left Ventricular Function and Perfusion in Cardiomyopathies by 123I-MIBG SPECT and 99mTc-Tetrofosmin Electrocardiographically Gated SPECT

Chunlei Zhao, Noriyuki Shuke, Wakako Yamamoto, Atsutaka Okizaki, Junichi Sato, Yukio Ishikawa, Takahumi Ohta, Naoyuki Hasebe, Kenjiro Kikuchi and Tamio Aburano
Journal of Nuclear Medicine July 2001, 42 (7) 1017-1024;

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Tables

  • TABLE 1

    Global and Regional Parameters in Study

    Parameters of CSNF
        Global
          GW: global % washout of MIBG
          H/Me, H/Md: early and delayed H/M in MIBG study
        Regional
          RW: regional % washout of MIBG
          MUPe, MUPd: early and delayed MIBG uptake
    Parameters of LV function
        Global
          LVEF: LV ejection fraction
        Regional
          TH: wall thickening
    Parameters of myocardial perfusion
        Global
          H/M-tetrofosmin: H/M in tetrofosmin study
        Regional
          UPes: tetrofosmin uptake at end-systole
  • TABLE 2

    Patients’ Age and Global Parameters in NC, DCM, and HCM

    ParameterNC (n = 5)DCMHCM
    Non-HF (n = 8)HF (n = 7)Overall (n = 15)Non-DP (n = 14)DP (n = 4)Overall (n = 18)
    Age (y)47.6 ± 12.6858.38 ± 15.4558.14 ± 9.658.27 ± 12.655.93 ± 19.0860.25 ± 6.8056.89 ± 17.03
    LVEF (%)71 ± 11.2233.5 ± 7.84*22 ± 8.35*†28.13 ± 9.79*50.29 ± 10.82*37.75 ± 1.5*‡47.5 ± 10.9*§
    H/M-TF2.92 ± 0.542.62 ± 0.312.46 ± 0.462.55 ± 0.383.32 ± 0.512.92 ± 0.333.23 ± 0.5§
    H/Me2.17 ± 0.051.89 ± 0.341.8 ± 0.18*1.85 ± 0.27*2.39 ± 0.33*1.91 ± 0.20‡2.28 ± 0.36§
    H/Md2.66 ± 0.211.91 ± 0.48*1.73 ± 0.39*1.82 ± 0.44*2.36 ± 0.292.03 ± 0.29*2.28 ± 0.31*§
    GW (%)11.88 ± 7.2333.34 ± 9.02*31.58 ± 11.18*32.52 ± 9.75*26.47 ± 7.01*23.64 ± 10.3425.84 ± 7.61*§

    • ↵* P < 0.05 vs. NC.

    • ↵† P < 0.05 vs. non-HF.

    • ↵‡ P < 0.05 vs. non-DP.

    • ↵§ P < 0.05 vs. DCM (overall).

    • n = case number; Non-HF = nonheart failure; HF = heart failure; Non-DP = nondilated phase; DP = dilated phase; H/M-TF = H/M in tetrofosmin study; H/Me = early H/M in MIBG study; H/Md = delayed H/M in MIBG study.

    • Data are presented as mean ± SD.

  • TABLE 3

    Regional Parameters in NC, DCM, and HCM

    ParameterNCDCMHCM
    Non-HFHFOverallNon-DPDPOverall
    TH (%)54.55 ± 17.67 (60)23.51 ± 10.79* (96)16.82 ± 9.64*† (84)20.39 ± 10.77* (180)31.61 ± 14.82* (168)17.56 ± 5.90*‡ (48)28.49 ± 14.57*§ (216)
    UPes2.36 ± 0.52 (60)1.86 ± 0.52* (96)1.78 ± 0.57* (84)1.82 ± 0.54* (180)2.75 ± 0.55* (168)1.84 ± 0.76*‡ (48)2.55 ± 0.71*§ (216)
    RW (%)1.04 ± 16.8 (60)32.08 ± 20.20* (84)38.18 ± 18.52*† (84)35.13 ± 19.56* (168)31.00 ± 14.62* (168)26.51 ± 18.30* (36)30.21 ± 15.38*§ (204)
    MUPe1.68 ± 0.29 (60)1.49 ± 0.40* (84)1.36 ± 0.33*† (84)1.43 ± 0.37* (168)1.90 ± 0.43* (168)1.30 ± 0.42*‡ (36)1.79 ± 0.48*§ (204)
    MUPd2.12 ± 0.36 (60)1.51 ± 0.47* (84)1.23 ± 0.52*† (84)1.37 ± 0.51* (168)1.80 ± 0.49* (168)1.39 ± 0.55*‡ (36)1.73 ± 0.52*§ (204)

    • ↵* P < 0.05 vs. NC.

    • ↵† P < 0.05 vs. non-HF.

    • ↵‡ P < 0.05 vs. non-DP.

    • ↵§ P < 0.05 vs. DCM (overall).

    • Non-HF = nonheart failure; HF = heart failure; Non-DP = nondilated phase; DP = dilated phase; UPes = tetrofosmin uptake at end-systole; RW = regional % washout of MIBG; MUPe = early MIBG uptake; MUPd = delayed MIBG uptake.

    • Data are presented as mean ± SD. Values in parentheses are number of myocardial segments.

  • TABLE 4

    Correlation Coefficients (r values) Between Regional Parameters

    ParameterTHUPes
    DCM (n = 168)HCM (n = 204)DCM (n = 168)HCM (n = 204)
    RW−0.412*−0.350*−0.372*0.274*
    MUPe0.356*0.198*0.419*0.461*
    MUPd0.459*0.349*0.457*0.217*

    • ↵* P < 0.01.

    • UPes = tetrofosmin uptake at end-systole; n = number of myocardial segments; RW = regional % washout of MIBG; MUPe = early MIBG uptake; MUPd = delayed MIBG uptake.

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