Patient Dosimetry of Intravenously Administered 99mTc-Annexin V

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FIGURE 1.
Anterior (A) and posterior (B) views from whole-body scan of volunteer at 5 h after intravenous injection of 440 MBq ^99mTc-i-AnxV.
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FIGURE 2.
Decay-corrected time–^99mTc uptake curves for blood (A), liver (B), left kidney (C), and spleen (D) after intravenous injection of ^99mTc-i-AnxV. Curves with mean and mean ± 1 SD are shown.

TABLE 1.

Dosimetric Data for Intravenously Administered ^99mTc-i-AnxV (n = 8)

Organ	Uptake at 4 h after injection* (%ID)	Effective half-life† (h)	Residence time (h)	Absorbed dose (μGy/MBq)
Kidneys	21.0 ± 5.6‡	6.3 ± 0.4	1.75 ± 0.40	93 ± 24
Liver	12.8 ± 2.2	5.5 ± 0.2	1.11 ± 0.15	17 ± 2
RM	4.2 ± 1.6	5.1 ± 0.4	0.34 ± 0.11	5.5 ± 0.8
Spleen	2.5 ± 1.3	5.2 ± 0.7	0.17 ± 0.08	22 ± 6
Testes (n = 6)	0.51 ± 0.10	5.1 ± 0.5	0.042 ± 0.009	15 ± 3
Thyroid	0.21 ± 0.11	4.6 ± 0.5	0.016 ± 0.009	10 ± 6
Urinary bladder§			0.13 ± 0.03	7.5 ± 2.6
Remainder			4.0 ± 0.7
Total body	91.0 ± 6	5.5 ± 0.2	7.5 ± 0.4

↵* Uptake values are corrected for physical decay.
↵† Results are from fit with single exponential.
↵‡ Computed as 2× left kidney uptake (10.5% ± 2.8%).
↵§ Dynamic bladder model (16); voiding interval = 4 h; biologic half-life of activity in total body from individual measurements (average, 62 ± 13 h); fraction of activity to urine = 0.75.