Parametric Images of Antibody Pharmacokinetics in Bi213-HuM195 Therapy of Leukemia

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FIGURE 1.
Pictograph of steps for generating parametric images. On top is series of four spot images taken at sequential time points. Spatially identical pixel (in green) has been selected from each image and fit to a line. Slope (m) is placed in image matrix at corresponding point.
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FIGURE 2.
Top row shows parametric images of patient 1. Generated isorate contours of 0.7 and −1.8 cpm are displayed on anterior view and 1.2 and 2.4 cpm are shown on posterior view. Isolevels are also superimposed on corresponding summed planar images in bottom row.
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FIGURE 3.
Anterior and posterior parametric images of patient 2 with isorate contours of −0.15 and 0.08 cpm shown on anterior view and 0.25 and 0.45 cpm shown on posterior view.
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FIGURE 4.
Parametric images of patient 3 show single isorate level of 0.14 cpm.
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FIGURE 5.
Parametric images of patient 4 show functional image artifacts. Movement that is apparent from rate image—particularly in hip and spleen region of posterior, first injection—cannot be plainly seen on conventional images.

TABLE 1.

Administered Antibody and Disease Assessment per Patient

Patient no.	Antibody dose (mg)			Bone marrow blasts (%)		WBCs*
Patient no.	First	Last	Total	Before treatment	After treatment	Before treatment	Nadir
1	1.630	1.480	4.590	38	24	2.8	0.1
2	0.699	0.653	5.071	28	6	1.8	0.4
3	0.898	0.891	3.585	67	50	3.2	0.9
4	1.18	1.03	3.37	20	11	5.6	0.2