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Journal of Nuclear Medicine

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OtherCLINICAL INVESTIGATIONS

Somatostatin Receptor Scintigraphy and Gallium Scintigraphy in Patients with Sarcoidosis

Rachida Lebtahi, Bruno Crestani, Nadia Belmatoug, Doumit Daou, Remi Genin, Marie Christine Dombret, Elisabeth Palazzo, Marc Faraggi, Michel Aubier and Dominique Le Guludec
Journal of Nuclear Medicine January 2001, 42 (1) 21-26;
Rachida Lebtahi
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Bruno Crestani
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Nadia Belmatoug
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Doumit Daou
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Remi Genin
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Marie Christine Dombret
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Elisabeth Palazzo
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Marc Faraggi
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Michel Aubier
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Dominique Le Guludec
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  • FIGURE 1.
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    FIGURE 1.

    Planar images of head and chest in patient with sarcoidosis 2 wk after corticosteroid therapy was stopped. (A) Gallium scintigraphy shows high uptake in nose, lacrimal glands, and salivary glands and mild uptake in skin lesion and in hilar and mediastinal lymph nodes. (B) SRS shows high uptake in nose; meningeal, lacrimal, and salivary glands; hilum and mediastinal area; lung; and two skin lesions, one on shoulder and one on neck.

  • FIGURE 2.
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    FIGURE 2.

    Coronal thoracic SPECT. (A) 67Ga images show mild uptake in skin lesion (arrow) and in hilar and mediastinal lymph nodes. (B) 111In-pentetreotide images show high uptake in hilar and mediastinal lymph nodes and in lung, skin lesions, and right axillary lymph node.

  • FIGURE 3.
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    FIGURE 3.

    Planar images of head and chest in patient with sarcoidosis treated by steroid therapy with decreasing doses (3 mg/day at time of scintigraphic evaluation). (A) Gallium scintigraphy shows only mildly increased uptake in hilar and mediastinal lymph nodes and in lung. (B) SRS shows high uptake with well-delineated lesions in hilar and mediastinal lymph nodes and in lung and reveals corticomeningeal and skull involvement, which was confirmed after SRS by cerebral MRI.

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    TABLE 1.

    Evaluation of Sarcoidosis Involvement in 18 Patients: Results for Both Procedures Expressed as Number of Involved Sites

    Clinically involved sitesGASRS
    Lungs (n = 26)2226
    Hilum or mediastinum (n = 30)2130
    Salivary glands (n = 8)77
    Lacrimal glands (n = 5)43
    Eye (uveitis: n = 1)00
    Central nervous system (n = 5)03
    Skin (n = 8)12
    Peripheral lymph nodes (n = 2)12
    Liver (n = 5)44
    Spleen (n = 4)24
    Palate (n = 1)11
    Heart (pericarditis: n = 1)00
    Muscle (n = 3)10
    Total6482*
    • ↵* P < 0.001.

    • GA = gallium scintigraphy.

    • View popup
    TABLE 2.

    Sites Revealed by SRS, Gallium Scintigraphy, or Both

    Sites revealedGASRS
    Salivary glands42
    Lacrimal glands31
    Nose or sinuses11
    Central nervous system01
    Peripheral lymph nodes1016
    Bone13
    • GA = gallium scintigraphy.

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Journal of Nuclear Medicine
Vol. 42, Issue 1
January 1, 2001
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Somatostatin Receptor Scintigraphy and Gallium Scintigraphy in Patients with Sarcoidosis
Rachida Lebtahi, Bruno Crestani, Nadia Belmatoug, Doumit Daou, Remi Genin, Marie Christine Dombret, Elisabeth Palazzo, Marc Faraggi, Michel Aubier, Dominique Le Guludec
Journal of Nuclear Medicine Jan 2001, 42 (1) 21-26;

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Somatostatin Receptor Scintigraphy and Gallium Scintigraphy in Patients with Sarcoidosis
Rachida Lebtahi, Bruno Crestani, Nadia Belmatoug, Doumit Daou, Remi Genin, Marie Christine Dombret, Elisabeth Palazzo, Marc Faraggi, Michel Aubier, Dominique Le Guludec
Journal of Nuclear Medicine Jan 2001, 42 (1) 21-26;
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