Article Figures & Data
Figures
- FIGURE 1.
A 69-y-old man with CNS lymphoma (patient 2). (A) T1-weighted MR image with gadolinium-diethylenetriaminepentaacetic acid shows homogenous enhancing lesions in midbrain and corpus callosum. (B) Midbrain tumor shows normal and high accumulation (arrowheads) on early (left) and delayed (right) SPECT images, respectively. (C) Early (left) and delayed (right) 123I-IMP SPECT images reveal increased uptake at corpus callosum.
- FIGURE 2.
A 52-y-old man with CNS lymphoma (patient 11). (A) T1-weighted MR image with gadolinium-diethylenetriaminepentaacetic acid shows heterogeneously enhancing mass in right parieto-occipital area. Mass is difficult to distinguish from high-grade glioma on MR image only. (B) 123I-IMP SPECT images show normal and increased accumulation (arrowheads) corresponding to tumor on early (left) and delayed (right) images, respectively.
- FIGURE 3.
A 72-y-old man with glioblastoma. (A) T1-weighted MR image with gadolinium-diethylenetriaminepentaacetic acid shows heterogeneously enhancing mass in left parietal region. (B) 123I-IMP SPECT images show defect (arrowheads) corresponding to tumor on both early (left) and delayed (right) images. T/Ns on early and delayed images are 0.23 and 0.21, respectively. T/Cs on early and delayed images are 0.18 and 0.20, respectively.
- FIGURE 4.
A 71-y-old woman with right parasagittal meningioma. 123I-IMP SPECT images show low accumulation and defect (arrowheads) corresponding to tumor on early (left) and delayed (right) images, respectively. T/Ns on early and delayed images are 0.53 and 0.48, respectively. T/Cs on early and delayed images are 0.18 and 0.14, respectively.
Tables
- TABLE 1.
Clinical Features and 123I-IMP SPECT Results for Patients with Non-Hodgkin's Lymphoma of Central Nervous System
Patient no. Age (y) Sex Tumor type Tumor location Tumor volume (cm3) Visual image T/N T/C Early Delayed Early Delayed Early Delayed 1 77 F Metastasis L thalamus to temporoparietal region 6.2 Low High 0.77 1.30 0.51 1.36 2 69 M Primary Midbrain 5.4 Normal High 1.16 1.25 0.80 0.92 Splenium of corpus callosum 12.0 High High 1.92* 2.25* 1.06 1.23 3 62 M Primary R paraventricle 4.0 Low High 0.62* 1.31* 0.53 0.95 L paraventricle 3.6 Low High 0.60* 1.42* 0.50 1.00 4 72 F Primary Intraventricular region 7.4 High High 2.01 2.72 0.75 0.95 5 81 F Primary L parietal region 2.5 Low Normal 0.41 1.00 0.41 1.05 6 73 M Primary L temporal region 3.2 Normal High 1.14 1.53 0.95 1.11 7 74 M Primary Corona radiata to centrum semiovale 2.5 Normal Normal 1.00 1.14 0.70 0.84 8 48 M Primary R basal ganglia 6.0 Low High 0.50 1.42 0.45 0.96 Midbrain 3.0 Normal High 0.85 1.20 0.74 1.04 9 58 F Primary R parietal region 4.5 Normal High ND ND ND ND L basal ganglia 2.4 Normal Normal ND ND ND ND 10 43 M Primary R parietal region 5.0 Normal High 1.07* 1.41* 0.68 1.20 L parietal region 4.0 Normal High 1.03* 1.35* 0.67 1.10 Pons 3.4 High High 1.76 1.54 1.35 1.05 11 52 M Primary R parietooccipital region 4.6 Normal High 1.00 1.40 0.96 1.00 12 79 F Primary L frontal region 9.4 Low High 0.59 1.52 0.43 1.42 ↵* Mirror image ROI using horizontal symmetry axis was used.
Metastasis = metastatic intracranial lymphoma from extracranial origin; primary = primary intracranial lymphoma; ND = no data.
Patient 1 had metastatic lymphoma from breast origin. Patients 2, 3, 8, 9, and 10 had 2 separated lesions. Patient 10 had recurrent lesion in pons.
Diagnosis T/N T/C Early Delayed Early Delayed CNS lymphoma 1.03 ± 0.47 1.48 ± 0.42 0.67 ± 0.21 1.08 ± 0.16 Glioma* 0.30 ± 0.10† 0.30 ± 0.05† 0.31 ± 0.09† 0.31 ± 0.07† Meningioma‡ 0.56 ± 0.46§ 0.34 ± 0.10† 0.59 ± 0.49‖ 0.41 ± 0.17† ↵* Data were obtained from 4 glioblastomas, 4 anaplastic astrocytomas, and 2 low-grade gliomas. Uptake did not significantly differ among these 3 groups.
↵† P < 0.05.
↵‡ Data were obtained from 10 meningiomas of 3 different histologic subtypes (3 meningotheliomatous, 3 fibroblastic, 4 transitional). Uptake did not significantly differ among histologic subtypes.
↵§ P = 0.10.
↵‖ P = 0.59 vs. CNS lymphoma.
Patient no. Study Age (y) Sex Diagnosis 123I-IMP SPECT results Early Delayed 1 Nakano et al. (16) 65 M Primary CNS lymphoma Low High 2 Nakano et al. (16) 58 F Malignant astrocytoma Low High 3 Nakano et al. (16) 58 F Metastatic brain tumor (histology was not described) Low High 4 Ohkawa et al. (18) 73 M Primary CNS lymphoma High High 5 Nishizawa et al. (17) 44 M Metastatic brain tumor (metastasis from bronchial carcinoid tumor) High High 6 Kitanaka et al. (15) 42 F Secondary CNS lymphoma (metastasis from breast lymphoma) High High 7 Takano et al. (19) 34 M Primary CNS melanoma High High 8 Yoshizawa et al. (20) 37 F Primary CNS lymphoma High High
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