RT Journal Article
SR Electronic
T1 The Diagnostic Value of <sup>123</sup>I-IMP SPECT in Non-Hodgkin's Lymphoma of the Central Nervous System
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1777
OP 1783
VO 41
IS 11
A1 Yasuhiko Akiyama
A1 Kouzo Moritake
A1 Toshiki Yamasaki
A1 Yoriyoshi Kimura
A1 Akira Kaneko
A1 Yoshiaki Yamamoto
A1 Takeshi Miyazaki
A1 Mitsuhiro Daisu
YR 2000
UL http://jnm.snmjournals.org/content/41/11/1777.abstract
AB N-isopropyl-p-[123I]iodoamphetamine (IMP) SPECT is of low diagnostic value in patients with brain tumors, because brain tumors are visualized as uptake defects. Some reports have described non-Hodgkin's lymphoma of the central nervous system (CNS) as showing high uptake on delayed 123I-IMP SPECT images, suggesting its usefulness in diagnosing CNS lymphoma. In this study, we investigated the clinical value of 123I-IMP SPECT as a diagnostic tool for CNS lymphoma. Methods: Ninety-six patients with brain tumors, including 12 patients with CNS lymphoma, underwent 123I-IMP SPECT. Eleven patients had primary CNS lymphoma, and 1 had a parenchymal brain metastasis from a breast lymphoma. The total number of lesions was 18, 14 of which were in the cerebral parenchyma, 3 in the brain stem, and 1 in the ventricle. Early SPECT images were initiated 15–30 min after intravenous injection of 111 MBq 123I-IMP, and delayed images were collected 4 h later. SPECT images were visually analyzed with a color-grading scale. Tumor-to-normal activity ratio (T/N) and tumor-to-cerebellum activity ratio (T/C) were calculated for both early and delayed images for semiquantitative analysis. Results: By visual estimation, more than a 3- cm3 volume of CNS lymphoma was detected as an obvious focus of increased accumulation on delayed images. All other brain tumors tested appeared as decreased accumulation on delayed images. T/Ns and T/Cs on delayed images of CNS lymphomas, including tumors less than 3 cm3 in volume, were 1.48 ± 0.42 and 1.08 ± 0.16, respectively. These ratios in patients with glioma (0.30 ± 0.05 and 0.31 ± 0 07 respectively) or meningioma (0.34 ± 0.10 and 0.41 ± 0.17, respectively) showed a significant difference from those in patients with CNS lymphoma (P &lt; 0.0005). Conclusion: 123I-IMP SPECT is a helpful tool for diagnosing CNS lymphoma.