HER2

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Designed Ankyrin Repeat Protein–Mediated Peptide Nucleic Acid–Based Pretargeting: A Proof-of-Principle Study
Maryam Oroujeni, Kristina Westerlund, Eleftherios Papalanis, Alexander van Deventer, Yongsheng Liu, Jacob Clinton, Zhengyue Wang, Ivan Zelepukin, Anna Orlova, Vladimir Tolmachev and Amelie Eriksson Karlström

Journal of Nuclear Medicine May 15, 2025, jnumed.125.269533; DOI: https://doi.org/10.2967/jnumed.125.269533
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Detection of HER2-Low Lesions Using HER2-Targeted PET Imaging in Patients with Metastatic Breast Cancer: A Paired HER2 PET and Tumor Biopsy Analysis
Randy Yeh, Fresia Pareja, Parnian Shobeiri, Dara Ross, Vetri S. Jayaprakasam, Ali Aria Razmaria, Joshua Z. Drago, Audrey Mauguen, Serge K. Lyashchenko, Brian M. Zeglis, Jason S. Lewis and Gary A. Ulaner

Journal of Nuclear Medicine May 8, 2025, jnumed.124.269227; DOI: https://doi.org/10.2967/jnumed.124.269227
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Whole-Body HER2 Heterogeneity Identified on HER2 PET in HER2-Negative, -Low, and -Positive Metastatic Breast Cancer
Bertha Eisses, Jasper J.L. van Geel, Adrienne H. Brouwers, Frederike Bensch, Sjoerd G. Elias, Evelien J.M. Kuip, Agnes Jager, Bert van der Vegt, Marjolijn N. Lub-de Hooge, Jasper Emmering, Anne I.J. Arens, Gerben J.C. Zwezerijnen, Daniëlle J. Vugts, C. Willemien Menke-van der Houven van Oordt, Elisabeth G.E. de Vries and Carolina P. Schröder

Journal of Nuclear Medicine October 1, 2024, 65 (10) 1540-1547; DOI: https://doi.org/10.2967/jnumed.124.267636
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First-in-Human Evaluation of Site-Specifically Labeled ⁸⁹Zr-Pertuzumab in Patients with HER2-Positive Breast Cancer
Randy Yeh, Joseph A. O’Donoghue, Vetri Sudar Jayaprakasam, Audrey Mauguen, Ryan Min, Sue Park, Julia P. Brockway, Jacqueline F. Bromberg, W Iris Zhi, Mark E. Robson, Rachel Sanford, Shanu Modi, Brian J. Agnew, Serge K. Lyashchenko, Jason S. Lewis, Gary A. Ulaner and Brian M. Zeglis

Journal of Nuclear Medicine March 1, 2024, 65 (3) 386-393; DOI: https://doi.org/10.2967/jnumed.123.266392
Open Access
Phase II Trial Assessing the Repeatability and Tumor Uptake of [⁶⁸Ga]Ga-HER2 Single-Domain Antibody PET/CT in Patients with Breast Carcinoma
Odrade Gondry, Vicky Caveliers, Catarina Xavier, Laurens Raes, Marian Vanhoeij, Guy Verfaillie, Christel Fontaine, Katrien Glorieus, Jacques De Grève, Sofie Joris, Ine Luyten, Karen Zwaenepoel, Frederik Vandenbroucke, Wim Waelput, Sheeno Thyparambil, Ilse Vaneycken, Julie Cousaert, Sophie Bourgeois, Nick Devoogdt, Lode Goethals, Hendrik Everaert, Frank De Geeter, Tony Lahoutte and Marleen Keyaerts

Journal of Nuclear Medicine February 1, 2024, 65 (2) 178-184; DOI: https://doi.org/10.2967/jnumed.123.266254
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Effective Treatment of Human Breast Carcinoma Xenografts with Single-Dose ²¹¹At-Labeled Anti-HER2 Single-Domain Antibody Fragment
Yutian Feng, Rebecca Meshaw, Xiao-Guang Zhao, Stephen Jannetti, Ganesan Vaidyanathan and Michael R. Zalutsky

Journal of Nuclear Medicine January 1, 2023, 64 (1) 124-130; DOI: https://doi.org/10.2967/jnumed.122.264071
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Affibody-Mediated PNA-Based Pretargeted Cotreatment Improves Survival of Trastuzumab-Treated Mice Bearing HER2-Expressing Xenografts
Maryam Oroujeni, Hanna Tano, Anzhelika Vorobyeva, Yongsheng Liu, Olga Vorontsova, Tianqi Xu, Kristina Westerlund, Anna Orlova, Vladimir Tolmachev and Amelie Eriksson Karlström

Journal of Nuclear Medicine July 1, 2022, 63 (7) 1046-1051; DOI: https://doi.org/10.2967/jnumed.121.262123
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Phase I Trial of ^99mTc-(HE)₃-G3, a DARPin-Based Probe for Imaging of HER2 Expression in Breast Cancer
Olga Bragina, Vladimir Chernov, Alexey Schulga, Elena Konovalova, Eugeniy Garbukov, Anzhelika Vorobyeva, Anna Orlova, Liubov Tashireva, Jens Sörensen, Roman Zelchan, Anna Medvedeva, Sergey Deyev and Vladimir Tolmachev

Journal of Nuclear Medicine April 1, 2022, 63 (4) 528-535; DOI: https://doi.org/10.2967/jnumed.121.262542
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Site-Specific and Residualizing Linker for ¹⁸F Labeling with Enhanced Renal Clearance: Application to an Anti-HER2 Single-Domain Antibody Fragment
Zhengyuan Zhou, Rebecca Meshaw, Michael R. Zalutsky and Ganesan Vaidyanathan

Journal of Nuclear Medicine November 1, 2021, 62 (11) 1624-1630; DOI: https://doi.org/10.2967/jnumed.120.261446
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Utility of ²¹¹At-Trastuzumab for the Treatment of Metastatic Gastric Cancer in the Liver: Evaluation of a Preclinical α-Radioimmunotherapy Approach in a Clinically Relevant Mouse Model
Huizi Keiko Li, Yukie Morokoshi, Satoshi Kodaira, Tamon Kusumoto, Katsuyuki Minegishi, Hiroaki Kanda, Kotaro Nagatsu and Sumitaka Hasegawa

Journal of Nuclear Medicine October 1, 2021, 62 (10) 1468-1474; DOI: https://doi.org/10.2967/jnumed.120.249300

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