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Journal of Nuclear Medicine

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Research ArticleClinical Investigation

[11C]Carfentanil PET Whole-Body Imaging of μ-Opioid Receptors: A First in-Human Study

Jacob G. Dubroff, Chia-Ju Hsieh, Corinde E. Wiers, Hsiaoju Lee, Alexander Schmitz, Elizabeth J. Li, Erin K. Schubert, Robert H. Mach and Henry R. Kranzler
Journal of Nuclear Medicine May 2025, jnumed.124.269413; DOI: https://doi.org/10.2967/jnumed.124.269413
Jacob G. Dubroff
1Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania;
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Chia-Ju Hsieh
1Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania;
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Corinde E. Wiers
2Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; and
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Hsiaoju Lee
1Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania;
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Alexander Schmitz
1Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania;
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Elizabeth J. Li
1Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania;
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Erin K. Schubert
1Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania;
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Robert H. Mach
1Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania;
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Henry R. Kranzler
2Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; and
3Mental Illness Research, Education and Clinical Center, Crescenz VAMC, Philadelphia, Pennsylvania
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Journal of Nuclear Medicine: 66 (6)
Journal of Nuclear Medicine
Vol. 66, Issue 6
June 1, 2025
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[11C]Carfentanil PET Whole-Body Imaging of μ-Opioid Receptors: A First in-Human Study
Jacob G. Dubroff, Chia-Ju Hsieh, Corinde E. Wiers, Hsiaoju Lee, Alexander Schmitz, Elizabeth J. Li, Erin K. Schubert, Robert H. Mach, Henry R. Kranzler
Journal of Nuclear Medicine May 2025, jnumed.124.269413; DOI: 10.2967/jnumed.124.269413

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[11C]Carfentanil PET Whole-Body Imaging of μ-Opioid Receptors: A First in-Human Study
Jacob G. Dubroff, Chia-Ju Hsieh, Corinde E. Wiers, Hsiaoju Lee, Alexander Schmitz, Elizabeth J. Li, Erin K. Schubert, Robert H. Mach, Henry R. Kranzler
Journal of Nuclear Medicine May 2025, jnumed.124.269413; DOI: 10.2967/jnumed.124.269413
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Keywords

  • μ-opioid receptors
  • [11C]carfentanil
  • naloxone
  • PET
  • PennPET Explorer
  • reference region
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