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Journal of Nuclear Medicine

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Research ArticleBrief Communication
Open Access

First-in-Human Serum Stability Studies of [177Lu]Lu-AMTG: A Step Toward Improved GRPR-Targeted Radiopharmaceutical Therapy

Veronika Felber, Nadine Holzleitner, Markus Joksch, Tim Suhrbier, Gunhild von Amsberg, Sarah Schwarzenböck, Jens Kurth, Martin Heuschkel, Thomas Günther and Bernd J. Krause
Journal of Nuclear Medicine April 2025, jnumed.124.269132; DOI: https://doi.org/10.2967/jnumed.124.269132
Veronika Felber
1Department of Chemistry, TUM School of Natural Sciences, Technical University of Munich, Garching, Germany;
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Nadine Holzleitner
1Department of Chemistry, TUM School of Natural Sciences, Technical University of Munich, Garching, Germany;
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Markus Joksch
2Department of Nuclear Medicine, Rostock University Medical Center, Rostock, Germany;
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Tim Suhrbier
2Department of Nuclear Medicine, Rostock University Medical Center, Rostock, Germany;
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Gunhild von Amsberg
3Department of Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; and
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Sarah Schwarzenböck
2Department of Nuclear Medicine, Rostock University Medical Center, Rostock, Germany;
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Jens Kurth
2Department of Nuclear Medicine, Rostock University Medical Center, Rostock, Germany;
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Martin Heuschkel
2Department of Nuclear Medicine, Rostock University Medical Center, Rostock, Germany;
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Thomas Günther
4Molecular Imaging Program at Stanford, Department of Radiology, School of Medicine, Stanford University, Stanford, California
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Bernd J. Krause
2Department of Nuclear Medicine, Rostock University Medical Center, Rostock, Germany;
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Journal of Nuclear Medicine: 66 (6)
Journal of Nuclear Medicine
Vol. 66, Issue 6
June 1, 2025
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First-in-Human Serum Stability Studies of [177Lu]Lu-AMTG: A Step Toward Improved GRPR-Targeted Radiopharmaceutical Therapy
Veronika Felber, Nadine Holzleitner, Markus Joksch, Tim Suhrbier, Gunhild von Amsberg, Sarah Schwarzenböck, Jens Kurth, Martin Heuschkel, Thomas Günther, Bernd J. Krause
Journal of Nuclear Medicine Apr 2025, jnumed.124.269132; DOI: 10.2967/jnumed.124.269132

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First-in-Human Serum Stability Studies of [177Lu]Lu-AMTG: A Step Toward Improved GRPR-Targeted Radiopharmaceutical Therapy
Veronika Felber, Nadine Holzleitner, Markus Joksch, Tim Suhrbier, Gunhild von Amsberg, Sarah Schwarzenböck, Jens Kurth, Martin Heuschkel, Thomas Günther, Bernd J. Krause
Journal of Nuclear Medicine Apr 2025, jnumed.124.269132; DOI: 10.2967/jnumed.124.269132
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Keywords

  • AMTG
  • in vivo serum stability
  • GRPR
  • first-in-human
  • 177Lu
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