Article Figures & Data
Figures
- FIGURE 1.
Consort diagram for patient selection.
- FIGURE 2.
Kaplan–Meier curves for OS, comparing groups dichotomized by DS, SUVmax, MTV, and TLG at 1 mo and 3 mo.
- FIGURE 3.
Kaplan–Meier curves for PFS, comparing groups dichotomized by DS, SUVmax, MTV, and TLG at 1 mo and 3 mo.
- FIGURE 4.
Kaplan–Meier curves for DoR, comparing groups dichotomized by DS, SUVmax, MTV, and TLG at 1 mo and 3 mo.
Tables
Characteristic Patients (n = 61) Age (y) 59 (48–65) Sex Female 18 (30) Male 43 (70) Disease stage at study entry I 1 (2) II 19 (31) III 8 (13) IV 33 (54) Diagnosis on central histologic review DLBCL 53 (87) PMBCL 8 (13) High-grade B-cell lymphoma 0 Double- or triple-hit rearrangement: MYC plus BCL2, BCL6, or both (n = 53) 6 (11) Cell of origin of cancer Germinal center B-cell type 16 (26) Nongerminal center B-cell type 28 (46) Activated B-cell 2 (3) Missing data 15 (25) Number of previous lines of antineoplastic therapy 1 1 (2) 2 33 (54) 3 16 (26) 4–8 11 (18) Relapse after last therapy 6 (10) Refractory DLBCL 55 (90) CAR-T product Axi-cel 34 (56) Tisa-cel 27 (44) Data are number with percentage in parentheses. Continuous data are median with IQR in parentheses.
SUVmax MTV TLG bPET 18.3 (9.7–25.2) 477.5 (30.3–399.9) 3,205.5 (185.1–2,837.0) PET1m 8.2 (0–13.6) 153.5 (0–54.6) 1,475.0 (0–391.0) PET3m 5.9 (0–10.2) 186.7 (0–12.1) 1,301.1 (0–59.3) Continuous data are median and IQR in parentheses.
- TABLE 3.
Metabolic PET/CT Parameter Cutoff Calculated Using Receiver Operating Characteristic (ROC) Curve Analysis Considering the Entire Cohort
ROC curve for OS ROC curve for PFS ROC curve for DoR Parameter Cutoff AUC (95% CI) P Sensitivity Specificity Cutoff AUC (95% CI) P Sensitivity Specificity Cutoff AUC (95% CI) P Sensitivity Specificity PET1m DS 4 4 4 SUVmax 9.1 0.736 0.0007 54% 88% 8.9 0.719 <0.0001 47% 91% 3.3 0.581 0.075 0.562 0.652 MTV 60.8 0.744 <0.0001 50% 94% 48.3 0.748 <0.0001 44% 100% 0.3 0.581 0.16 0.5 0.696 TLG 97.0 0.731 0.00065 58% 85% 204.6 0.731 <0.0001 47% 96% 0.5 0.571 0.18 0.562 0.609 PET3m DS 4 4 4 SUVmax 6.3 0.799 <0.0001 71% 87% 11.4 0.734 <0.0001 48% 100% 6.3 0.696 <0.0001 0.467 0.913 MTV 120.1 0.805 <0.0001 59% 97% 120.1 0.722 <0.0001 44% 100% 120.1 0.681 <0.0001 0.333 1 TLG 436.9 0.803 <0.0001 59% 97% 67.8 0.725 <0.0001 48% 100% 53.5 0.684 <0.0001 0.4 0.956 Cutoff of 4 for DS is clinical choice.
OS PFS DoR Parameter Beta HR (95% CI) Wald test P Beta HR (95% CI) Wald test P Beta HR (95% CI) Wald test P PET1m SUVmax 0.062 1.0644 (1.03–1.1) 12.2 <0.001 0.11 1.1175 (1.07–1.16) 30.3 <0.001 0.046 1.0466 (0.947–1.16) 0.8 0.372 MTV 0.0016 1.0016 (1–1) 15.8 <0.001 0.0019 1.0019 (1–1) 25.6 <0.001 0.0051 1.0051 (0.997–1.01) 1.7 0.193 TLG 0.00012 1.00012 (1–1) 11.3 <0.001 0.00014 1.0001 (1–1) 16.5 <0.001 −0.00015 0.9998 (0.999–1) 0.22 0.641 PET3m SUVmax 0.081 1.0839 (1.04–1.13) 13.6 <0.001 0.12 1.1268 (1.08–1.18) 26.5 <0.001 0.16 1.1697 (1.09–1.26) 18.7 <0.001 MTV 0.0012 1.00119 (1–1) 9.1 <0.001 0.00089 1.00099 (1–1) 12.6 <0.001 0.0098 1.0099 (1–1.02) 12.8 <0.001 TLG 0.0002 1.0002 (1–1) 12.0 <0.001 0.00015 1.00015 (1–1) 14.3 <0.001 0.0022 1.0022 (1–1) 16.9 <0.001 OS PFS DoR Parameter Beta HR (95% CI) Wald test P Beta HR (95% CI) Wald test P Beta HR (95% CI) Wald test P PET1m SUVmax 1.2 3.26 (1.22–8.75) 5.51 <0.05 1.2 3.23 (1.5–6.98) 8.92 <0.01 0.88 2.42 (0.89–6.55) 3.0 0.08 MTV 1.2 3.18 (1.26–8.03) 5.98 <0.05 1.2 3.44 (1.63–7.24) 10.5 <0.01 0.7 2.01 (0.75–5.39) 1.92 0.16 TLG 1.0 2.82 (1.05–7.56) 4.23 <0.05 1.2 3.33 (1.5–7.41) 8.74 <0.01 0.67 1.95 (0.72–5.3) 1.72 0.19 DS 0.98 2.66 (1.06–6.72) 4.3 <0.05 1.1 3.0 (1.42–6.32) 8.35 <0.01 0.67 1.95 (0.73–5.24) 1.76 0.18 PET3m SUVmax 2.1 8.15 (2.81–23.6) 15 <0.01 2.2 8.63 (3.68–20.2) 24.5 <0.01 2.0 7.15 (2.45–20.9) 12.9 <0.01 MTV 2.3 9.87 (3.65–26.7) 20.4 <0.01 3.5 33.7 (8.68–130.0) 25.9 <0.01 3.7 39.6 (7.29–215.0) 18.2 <0.01 TLG 2.0 7.44 (2.71–20.4) 15.2 <0.01 2.6 13.1 (5.4–31.8) 32.4 <0.01 2.4 11.0 (3.59–33.6) 17.6 <0.01 DS 1.7 5.53 (1.78–17.2) 8.78 <0.01 1.4 4.19 (1.82–9.64) 11.4 <0.01 1.3 3.67 (1.32–10.2) 6.2 <0.05 OS PFS DoR Parameter HR 95% CI P HR 95% CI P HR 95% CI P Age 1.1 1.02–1.19 0.014 — — — — — — BT 10.91 1.08–110.38 0.043 3.52 0.98–12.63 0.05 9.69 1.06–88.17 0.04 LDH 6.43 1.93–21.41 0.002 3.10 1.31–7.35 0.01 — — — Fibrinogen 5.27 1.29–21.51 0.021 — — — — — — Ferritin — — — — — — 0.33 0.11–1.0 0.05 SUVmax* 11.03 2.79–43.57 <0.001 66.17 13.07–335.04 <0.001 14.57 3.91–54.24 <0.001 ↵* SUVmax at PET3m.
Supplemental Data
Files in this Data Supplement:
In this issue
Jump to section
Related Articles
Cited By...
- No citing articles found.