Design, Synthesis, and Preclinical Evaluation of a High-Affinity 18F-Labeled Radioligand for Myocardial Growth Hormone Secretagogue Receptor Before and After Myocardial Infarction

Rebecca Sullivan; Jinqiang Hou; Lihai Yu; Benjamin Wilk; Jane Sykes; Heather Biernaski; John Butler; Michael Kovacs; Justin Hicks; Jonathan D. Thiessen; Rohan Dharmakumar; Frank S. Prato; Gerald Wisenberg; Leonard G. Luyt; Savita Dhanvantari

doi:10.2967/jnumed.124.267578

Research ArticleBasic Science Investigation

Design, Synthesis, and Preclinical Evaluation of a High-Affinity ¹⁸F-Labeled Radioligand for Myocardial Growth Hormone Secretagogue Receptor Before and After Myocardial Infarction

Rebecca Sullivan, Jinqiang Hou, Lihai Yu, Benjamin Wilk, Jane Sykes, Heather Biernaski, John Butler, Michael Kovacs, Justin Hicks, Jonathan D. Thiessen, Rohan Dharmakumar, Frank S. Prato, Gerald Wisenberg, Leonard G. Luyt and Savita Dhanvantari

Journal of Nuclear Medicine September 2024, jnumed.124.267578; DOI: https://doi.org/10.2967/jnumed.124.267578

Rebecca Sullivan

1Imaging Research Program, Lawson Health Research Institute, London, Ontario, Canada;

2Department of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada;

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Jinqiang Hou

3Lakehead University and Thunder Bay Regional Health Research Institute, Thunder Bay, Ontario, Canada;

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Lihai Yu

4London Regional Cancer Program, London, Ontario, Canada;

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Benjamin Wilk

1Imaging Research Program, Lawson Health Research Institute, London, Ontario, Canada;

5Department of Medical Biophysics, Western University, London, Ontario, Canada;

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Jane Sykes

1Imaging Research Program, Lawson Health Research Institute, London, Ontario, Canada;

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Heather Biernaski

1Imaging Research Program, Lawson Health Research Institute, London, Ontario, Canada;

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John Butler

1Imaging Research Program, Lawson Health Research Institute, London, Ontario, Canada;

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Michael Kovacs

1Imaging Research Program, Lawson Health Research Institute, London, Ontario, Canada;

5Department of Medical Biophysics, Western University, London, Ontario, Canada;

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Justin Hicks

1Imaging Research Program, Lawson Health Research Institute, London, Ontario, Canada;

5Department of Medical Biophysics, Western University, London, Ontario, Canada;

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Jonathan D. Thiessen

1Imaging Research Program, Lawson Health Research Institute, London, Ontario, Canada;

5Department of Medical Biophysics, Western University, London, Ontario, Canada;

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Rohan Dharmakumar

6Indiana School of Medicine, Indianapolis, Indiana; and

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Frank S. Prato

1Imaging Research Program, Lawson Health Research Institute, London, Ontario, Canada;

5Department of Medical Biophysics, Western University, London, Ontario, Canada;

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Gerald Wisenberg

1Imaging Research Program, Lawson Health Research Institute, London, Ontario, Canada;

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Leonard G. Luyt

4London Regional Cancer Program, London, Ontario, Canada;

7Departments of Chemistry, Oncology, and Medical Imaging, Western University, London, Ontario, Canada

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Savita Dhanvantari

1Imaging Research Program, Lawson Health Research Institute, London, Ontario, Canada;

2Department of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada;

5Department of Medical Biophysics, Western University, London, Ontario, Canada;

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Vol. 66, Issue 5

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Design, Synthesis, and Preclinical Evaluation of a High-Affinity ¹⁸F-Labeled Radioligand for Myocardial Growth Hormone Secretagogue Receptor Before and After Myocardial Infarction

Journal of Nuclear Medicine Sep 2024, jnumed.124.267578; DOI: 10.2967/jnumed.124.267578

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Design, Synthesis, and Preclinical Evaluation of a High-Affinity ¹⁸F-Labeled Radioligand for Myocardial Growth Hormone Secretagogue Receptor Before and After Myocardial Infarction

Journal of Nuclear Medicine Sep 2024, jnumed.124.267578; DOI: 10.2967/jnumed.124.267578

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cardiac
ghrelin
receptor
PET
preclinical

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Design, Synthesis, and Preclinical Evaluation of a High-Affinity ¹⁸F-Labeled Radioligand for Myocardial Growth Hormone Secretagogue Receptor Before and After Myocardial Infarction

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