Spleen Volume Reduction Is a Reliable and Independent Biomarker for Long-Term Risk of Leukopenia Development in Peptide Receptor Radionuclide Therapy

Lisa Steinhelfer; Friederike Jungmann; Lukas Endrös; Patrick Wenzel; Bernhard Haller; Manuel Nickel; Eva Haneder; Fabian Geisler; Katharina Götze; Alexander von Werder; Matthias Eiber; Markus R. Makowski; Rickmer Braren; Fabian Lohöfer

doi:10.2967/jnumed.123.267098

Research ArticleBasic Science Investigation

Spleen Volume Reduction Is a Reliable and Independent Biomarker for Long-Term Risk of Leukopenia Development in Peptide Receptor Radionuclide Therapy

Lisa Steinhelfer, Friederike Jungmann, Lukas Endrös, Patrick Wenzel, Bernhard Haller, Manuel Nickel, Eva Haneder, Fabian Geisler, Katharina Götze, Alexander von Werder, Matthias Eiber, Markus R. Makowski, Rickmer Braren and Fabian Lohöfer

Journal of Nuclear Medicine July 2024, jnumed.123.267098; DOI: https://doi.org/10.2967/jnumed.123.267098

Lisa Steinhelfer

1Department of Radiology, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany;

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Friederike Jungmann

1Department of Radiology, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany;

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Lukas Endrös

1Department of Radiology, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany;

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Patrick Wenzel

2Medical Clinic and Polyclinic II, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany;

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Bernhard Haller

3Institute of AI and Informatics in Medicine, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany;

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Manuel Nickel

3Institute of AI and Informatics in Medicine, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany;

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Eva Haneder

1Department of Radiology, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany;

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Fabian Geisler

2Medical Clinic and Polyclinic II, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany;

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Katharina Götze

4Medical Clinic and Polyclinic III, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany;

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Alexander von Werder

2Medical Clinic and Polyclinic II, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany;

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Matthias Eiber

5Department of Nuclear Medicine, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany; and

6German Cancer Consortium, a Partnership Between DKFZ and School of Medicine, Technical University of Munich, Munich, Germany

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Markus R. Makowski

1Department of Radiology, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany;

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Rickmer Braren

1Department of Radiology, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany;

6German Cancer Consortium, a Partnership Between DKFZ and School of Medicine, Technical University of Munich, Munich, Germany

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Fabian Lohöfer

1Department of Radiology, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany;

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Journal of Nuclear Medicine

Vol. 66, Issue 4

April 1, 2025

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Spleen Volume Reduction Is a Reliable and Independent Biomarker for Long-Term Risk of Leukopenia Development in Peptide Receptor Radionuclide Therapy

Journal of Nuclear Medicine Jul 2024, jnumed.123.267098; DOI: 10.2967/jnumed.123.267098

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Spleen Volume Reduction Is a Reliable and Independent Biomarker for Long-Term Risk of Leukopenia Development in Peptide Receptor Radionuclide Therapy

Journal of Nuclear Medicine Jul 2024, jnumed.123.267098; DOI: 10.2967/jnumed.123.267098

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Keywords

PRRT
spleen volumetry
imaging-based biomarker
177Lu-DOTATATE
leukopenia

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Spleen Volume Reduction Is a Reliable and Independent Biomarker for Long-Term Risk of Leukopenia Development in Peptide Receptor Radionuclide Therapy

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