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Research ArticleClinical Investigation

The Role of Fibroblast Activation Protein in Glioblastoma and Gliosarcoma: A Comparison of Tissue, 68Ga-FAPI-46 PET Data, and Survival Data

Christoph Oster, Lukas Kessler, Tobias Blau, Kathy Keyvani, Kim M. Pabst, Wolfgang P. Fendler, Pedro Fragoso Costa, Lazaros Lazaridis, Teresa Schmidt, Jonas Feldheim, Daniela Pierscianek, Hans Ulrich Schildhaus, Ulrich Sure, Yahya Ahmadipour, Christoph Kleinschnitz, Nika Guberina, Martin Stuschke, Cornelius Deuschl, Björn Scheffler, Ken Herrmann, Sied Kebir and Martin Glas
Journal of Nuclear Medicine July 2024, jnumed.123.267151; DOI: https://doi.org/10.2967/jnumed.123.267151
Christoph Oster
1Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Division of Clinical Neurooncology, University Medicine Essen, University Duisburg–Essen, Essen, Germany;
2German Cancer Consortium (DKTK), Partner Site Essen–Düsseldorf, Partnership Between DKFZ and University Hospital Essen, Essen, Germany; and DKFZ–Division of Translational Neurooncology at West German Cancer Center (WTZ), University Medicine Essen, University Duisburg–Essen, Essen, Germany;
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Lukas Kessler
3Department of Nuclear Medicine, University of Duisburg–Essen, and German Cancer Consortium (DKTK)–University Hospital Essen, Essen, Germany; and National Center for Tumor Diseases (NCT), NCT West, Essen, Germany;
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Tobias Blau
4Institute of Neuropathology, University Medicine Essen, University Duisburg-Essen, Essen, Germany;
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Kathy Keyvani
4Institute of Neuropathology, University Medicine Essen, University Duisburg-Essen, Essen, Germany;
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Kim M. Pabst
3Department of Nuclear Medicine, University of Duisburg–Essen, and German Cancer Consortium (DKTK)–University Hospital Essen, Essen, Germany; and National Center for Tumor Diseases (NCT), NCT West, Essen, Germany;
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Wolfgang P. Fendler
3Department of Nuclear Medicine, University of Duisburg–Essen, and German Cancer Consortium (DKTK)–University Hospital Essen, Essen, Germany; and National Center for Tumor Diseases (NCT), NCT West, Essen, Germany;
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Pedro Fragoso Costa
3Department of Nuclear Medicine, University of Duisburg–Essen, and German Cancer Consortium (DKTK)–University Hospital Essen, Essen, Germany; and National Center for Tumor Diseases (NCT), NCT West, Essen, Germany;
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Lazaros Lazaridis
1Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Division of Clinical Neurooncology, University Medicine Essen, University Duisburg–Essen, Essen, Germany;
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Teresa Schmidt
1Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Division of Clinical Neurooncology, University Medicine Essen, University Duisburg–Essen, Essen, Germany;
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Jonas Feldheim
1Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Division of Clinical Neurooncology, University Medicine Essen, University Duisburg–Essen, Essen, Germany;
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Daniela Pierscianek
5Department of Neurosurgery and Spine Surgery, Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Medicine Essen, University Duisburg–Essen, Essen, Germany;
6Department of Neurosurgery and Spine Surgery, St. Marienhospital Lünen, Lünen, Germany;
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Hans Ulrich Schildhaus
7Institute of Pathology, University Medicine Essen, University Duisburg-Essen, Essen, Germany;
8Discovery Life Sciences Biomarker Services GmbH, Kassel, Germany;
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Ulrich Sure
5Department of Neurosurgery and Spine Surgery, Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Medicine Essen, University Duisburg–Essen, Essen, Germany;
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Yahya Ahmadipour
5Department of Neurosurgery and Spine Surgery, Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Medicine Essen, University Duisburg–Essen, Essen, Germany;
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Christoph Kleinschnitz
1Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Division of Clinical Neurooncology, University Medicine Essen, University Duisburg–Essen, Essen, Germany;
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Nika Guberina
9Department of Radiotherapy, University Medicine Essen, University Duisburg-Essen, Essen, Germany;
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Martin Stuschke
9Department of Radiotherapy, University Medicine Essen, University Duisburg-Essen, Essen, Germany;
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Cornelius Deuschl
10Institute for Diagnostic and Interventional Radiology and Neuroradiology, University Medicine Essen, University of Duisburg-Essen, Essen, Germany;
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Björn Scheffler
2German Cancer Consortium (DKTK), Partner Site Essen–Düsseldorf, Partnership Between DKFZ and University Hospital Essen, Essen, Germany; and DKFZ–Division of Translational Neurooncology at West German Cancer Center (WTZ), University Medicine Essen, University Duisburg–Essen, Essen, Germany;
11German Cancer Research Center (DKFZ), Heidelberg, Germany; and
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Ken Herrmann
3Department of Nuclear Medicine, University of Duisburg–Essen, and German Cancer Consortium (DKTK)–University Hospital Essen, Essen, Germany; and National Center for Tumor Diseases (NCT), NCT West, Essen, Germany;
12National Center for Tumor Diseases (NCT), NCT West, Heidelberg, Germany
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Sied Kebir
1Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Division of Clinical Neurooncology, University Medicine Essen, University Duisburg–Essen, Essen, Germany;
2German Cancer Consortium (DKTK), Partner Site Essen–Düsseldorf, Partnership Between DKFZ and University Hospital Essen, Essen, Germany; and DKFZ–Division of Translational Neurooncology at West German Cancer Center (WTZ), University Medicine Essen, University Duisburg–Essen, Essen, Germany;
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Martin Glas
1Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Division of Clinical Neurooncology, University Medicine Essen, University Duisburg–Essen, Essen, Germany;
2German Cancer Consortium (DKTK), Partner Site Essen–Düsseldorf, Partnership Between DKFZ and University Hospital Essen, Essen, Germany; and DKFZ–Division of Translational Neurooncology at West German Cancer Center (WTZ), University Medicine Essen, University Duisburg–Essen, Essen, Germany;
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Article Information

jnumed.123.267151
DOI 
https://doi.org/10.2967/jnumed.123.267151
PubMed 
38960714

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication December 2, 2023
  • Accepted for publication May 22, 2024
  • Published online July 3, 2024.

Article Versions

  • You are currently viewing a previous version of this article (July 3, 2024 - 09:42).
  • View the most recent version of this article
Copyright & Usage 
© 2024 by the Society of Nuclear Medicine and Molecular Imaging.

Author Information

  1. Christoph Oster1,2,
  2. Lukas Kessler3,
  3. Tobias Blau4,
  4. Kathy Keyvani4,
  5. Kim M. Pabst3,
  6. Wolfgang P. Fendler3,
  7. Pedro Fragoso Costa3,
  8. Lazaros Lazaridis1,
  9. Teresa Schmidt1,
  10. Jonas Feldheim1,
  11. Daniela Pierscianek5,6,
  12. Hans Ulrich Schildhaus7,8,
  13. Ulrich Sure5,
  14. Yahya Ahmadipour5,
  15. Christoph Kleinschnitz1,
  16. Nika Guberina9,
  17. Martin Stuschke9,
  18. Cornelius Deuschl10,
  19. Björn Scheffler2,11,
  20. Ken Herrmann*,3,12,
  21. Sied Kebir*,1,2 and
  22. Martin Glas*,1,2
  1. 1Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Division of Clinical Neurooncology, University Medicine Essen, University Duisburg–Essen, Essen, Germany;
  2. 2German Cancer Consortium (DKTK), Partner Site Essen–Düsseldorf, Partnership Between DKFZ and University Hospital Essen, Essen, Germany; and DKFZ–Division of Translational Neurooncology at West German Cancer Center (WTZ), University Medicine Essen, University Duisburg–Essen, Essen, Germany;
  3. 3Department of Nuclear Medicine, University of Duisburg–Essen, and German Cancer Consortium (DKTK)–University Hospital Essen, Essen, Germany; and National Center for Tumor Diseases (NCT), NCT West, Essen, Germany;
  4. 4Institute of Neuropathology, University Medicine Essen, University Duisburg-Essen, Essen, Germany;
  5. 5Department of Neurosurgery and Spine Surgery, Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Medicine Essen, University Duisburg–Essen, Essen, Germany;
  6. 6Department of Neurosurgery and Spine Surgery, St. Marienhospital Lünen, Lünen, Germany;
  7. 7Institute of Pathology, University Medicine Essen, University Duisburg-Essen, Essen, Germany;
  8. 8Discovery Life Sciences Biomarker Services GmbH, Kassel, Germany;
  9. 9Department of Radiotherapy, University Medicine Essen, University Duisburg-Essen, Essen, Germany;
  10. 10Institute for Diagnostic and Interventional Radiology and Neuroradiology, University Medicine Essen, University of Duisburg-Essen, Essen, Germany;
  11. 11German Cancer Research Center (DKFZ), Heidelberg, Germany; and
  12. 12National Center for Tumor Diseases (NCT), NCT West, Heidelberg, Germany
  1. For correspondence or reprints, contact Martin Glas (martin.glas{at}uk-essen.de).
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The Role of Fibroblast Activation Protein in Glioblastoma and Gliosarcoma: A Comparison of Tissue, 68Ga-FAPI-46 PET Data, and Survival Data
Christoph Oster, Lukas Kessler, Tobias Blau, Kathy Keyvani, Kim M. Pabst, Wolfgang P. Fendler, Pedro Fragoso Costa, Lazaros Lazaridis, Teresa Schmidt, Jonas Feldheim, Daniela Pierscianek, Hans Ulrich Schildhaus, Ulrich Sure, Yahya Ahmadipour, Christoph Kleinschnitz, Nika Guberina, Martin Stuschke, Cornelius Deuschl, Björn Scheffler, Ken Herrmann, Sied Kebir, Martin Glas
Journal of Nuclear Medicine Jul 2024, jnumed.123.267151; DOI: 10.2967/jnumed.123.267151

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The Role of Fibroblast Activation Protein in Glioblastoma and Gliosarcoma: A Comparison of Tissue, 68Ga-FAPI-46 PET Data, and Survival Data
Christoph Oster, Lukas Kessler, Tobias Blau, Kathy Keyvani, Kim M. Pabst, Wolfgang P. Fendler, Pedro Fragoso Costa, Lazaros Lazaridis, Teresa Schmidt, Jonas Feldheim, Daniela Pierscianek, Hans Ulrich Schildhaus, Ulrich Sure, Yahya Ahmadipour, Christoph Kleinschnitz, Nika Guberina, Martin Stuschke, Cornelius Deuschl, Björn Scheffler, Ken Herrmann, Sied Kebir, Martin Glas
Journal of Nuclear Medicine Jul 2024, jnumed.123.267151; DOI: 10.2967/jnumed.123.267151
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Keywords

  • FAP
  • 68Ga-FAPI-46 PET
  • Glioblastoma
  • gliosarcoma
  • theranostic
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