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Research ArticleClinical Investigation
Open Access

Clinical Characterization of [18F]T-008, a Cholesterol 24-Hydroxylase PET Ligand: Dosimetry, Kinetic Modeling, Variability, and Soticlestat Occupancy

Cristian C. Constantinescu, Terry Brown, Shining Wang, Wei Yin, Olivier Barret, Danna Jennings and Johannes Tauscher
Journal of Nuclear Medicine September 2023, jnumed.123.265912; DOI: https://doi.org/10.2967/jnumed.123.265912
Cristian C. Constantinescu
1Invicro, New Haven, Connecticut; and
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Terry Brown
2Takeda Pharmaceutical Co. Ltd., Cambridge, Massachusetts
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Shining Wang
2Takeda Pharmaceutical Co. Ltd., Cambridge, Massachusetts
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Wei Yin
2Takeda Pharmaceutical Co. Ltd., Cambridge, Massachusetts
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Olivier Barret
1Invicro, New Haven, Connecticut; and
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Danna Jennings
1Invicro, New Haven, Connecticut; and
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Johannes Tauscher
2Takeda Pharmaceutical Co. Ltd., Cambridge, Massachusetts
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Article Information

jnumed.123.265912
DOI 
https://doi.org/10.2967/jnumed.123.265912
PubMed 
37770111

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication April 20, 2023
  • Revision received August 18, 2023
  • Published online September 28, 2023.

Article Versions

  • You are currently viewing a previous version of this article (September 28, 2023 - 08:44).
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Copyright & Usage 
© 2023 by the Society of Nuclear Medicine and Molecular Imaging. Immediate Open Access: Creative Commons Attribution 4.0 International License (CC BY) allows users to share and adapt with attribution, excluding materials credited to previous publications. License: https://creativecommons.org/licenses/by/4.0/. Details: http://jnm.snmjournals.org/site/misc/permission.xhtml.

Author Information

  1. Cristian C. Constantinescu1,
  2. Terry Brown2,
  3. Shining Wang2,
  4. Wei Yin2,
  5. Olivier Barret1,
  6. Danna Jennings1 and
  7. Johannes Tauscher2
  1. 1Invicro, New Haven, Connecticut; and
  2. 2Takeda Pharmaceutical Co. Ltd., Cambridge, Massachusetts
  1. For correspondence or reprints, contact Johannes Tauscher (johannes.tauscher{at}takeda.com).
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    ACS Pharmacology & Translational Science 2025 8 3

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Journal of Nuclear Medicine: 66 (6)
Journal of Nuclear Medicine
Vol. 66, Issue 6
June 1, 2025
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Clinical Characterization of [18F]T-008, a Cholesterol 24-Hydroxylase PET Ligand: Dosimetry, Kinetic Modeling, Variability, and Soticlestat Occupancy
Cristian C. Constantinescu, Terry Brown, Shining Wang, Wei Yin, Olivier Barret, Danna Jennings, Johannes Tauscher
Journal of Nuclear Medicine Sep 2023, jnumed.123.265912; DOI: 10.2967/jnumed.123.265912

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Clinical Characterization of [18F]T-008, a Cholesterol 24-Hydroxylase PET Ligand: Dosimetry, Kinetic Modeling, Variability, and Soticlestat Occupancy
Cristian C. Constantinescu, Terry Brown, Shining Wang, Wei Yin, Olivier Barret, Danna Jennings, Johannes Tauscher
Journal of Nuclear Medicine Sep 2023, jnumed.123.265912; DOI: 10.2967/jnumed.123.265912
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Keywords

  • soticlestat
  • cholesterol 24-hydroxylase
  • dose occupancy
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