Skip to main content

Main menu

  • Home
  • Content
    • Current
    • Ahead of print
    • Past Issues
    • JNM Supplement
    • SNMMI Annual Meeting Abstracts
    • Continuing Education
    • JNM Podcasts
  • Subscriptions
    • Subscribers
    • Institutional and Non-member
    • Rates
    • Journal Claims
    • Corporate & Special Sales
  • Authors
    • Submit to JNM
    • Information for Authors
    • Assignment of Copyright
    • AQARA requirements
  • Info
    • Reviewers
    • Permissions
    • Advertisers
  • About
    • About Us
    • Editorial Board
    • Contact Information
  • More
    • Alerts
    • Feedback
    • Help
    • SNMMI Journals
  • SNMMI
    • JNM
    • JNMT
    • SNMMI Journals
    • SNMMI

User menu

  • Subscribe
  • My alerts
  • Log in
  • Log out
  • My Cart

Search

  • Advanced search
Journal of Nuclear Medicine
  • SNMMI
    • JNM
    • JNMT
    • SNMMI Journals
    • SNMMI
  • Subscribe
  • My alerts
  • Log in
  • Log out
  • My Cart
Journal of Nuclear Medicine

Advanced Search

  • Home
  • Content
    • Current
    • Ahead of print
    • Past Issues
    • JNM Supplement
    • SNMMI Annual Meeting Abstracts
    • Continuing Education
    • JNM Podcasts
  • Subscriptions
    • Subscribers
    • Institutional and Non-member
    • Rates
    • Journal Claims
    • Corporate & Special Sales
  • Authors
    • Submit to JNM
    • Information for Authors
    • Assignment of Copyright
    • AQARA requirements
  • Info
    • Reviewers
    • Permissions
    • Advertisers
  • About
    • About Us
    • Editorial Board
    • Contact Information
  • More
    • Alerts
    • Feedback
    • Help
    • SNMMI Journals
  • View or Listen to JNM Podcast
  • Visit JNM on Facebook
  • Join JNM on LinkedIn
  • Follow JNM on Twitter
  • Subscribe to our RSS feeds
Research ArticleClinical Investigation
Open Access

Prognostic Value of TSPO PET Before Radiotherapy in Newly Diagnosed IDH–Wild-Type Glioblastoma

Nathalie L. Albert, Debie V. Nelwan, Daniel F. Fleischmann, Stefanie Quach, Katharina von Rohr, Lena Kaiser, Nico Teske, Lena M. Unterrainer, Laura M. Bartos, Viktoria C. Ruf, Matthias Brendel, Markus J. Riemenschneider, Christian Wetzel, Jochen Herms, Rainer Rupprecht, Niklas Thon, Joerg-Christian Tonn, Claus Belka, Peter Bartenstein, Louisa von Baumgarten, Maximilian Niyazi, Marcus Unterrainer and Adrien Holzgreve
Journal of Nuclear Medicine August 2023, jnumed.122.265247; DOI: https://doi.org/10.2967/jnumed.122.265247
Nathalie L. Albert
1Department of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany;
2German Cancer Consortium, Partner Site Munich, German Cancer Research Center, Munich, Germany;
3Bavarian Cancer Research Center, Erlangen, Germany;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Debie V. Nelwan
1Department of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Daniel F. Fleischmann
4Department of Radiation Oncology, LMU University Hospital, LMU Munich, Munich, Germany;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Stefanie Quach
5Department of Neurosurgery, LMU University Hospital, LMU Munich, Munich, Germany;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Katharina von Rohr
1Department of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lena Kaiser
1Department of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Nico Teske
2German Cancer Consortium, Partner Site Munich, German Cancer Research Center, Munich, Germany;
5Department of Neurosurgery, LMU University Hospital, LMU Munich, Munich, Germany;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lena M. Unterrainer
1Department of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Laura M. Bartos
1Department of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Viktoria C. Ruf
6Institute of Neuropathology, Faculty of Medicine, LMU Munich, Munich, Germany;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Matthias Brendel
1Department of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany;
7SyNergy, University of Munich, Munich, Germany;
8German Center for Neurodegenerative Diseases, Munich, Germany;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Markus J. Riemenschneider
9Department of Neuropathology, Regensburg University Hospital, Regensburg, Germany;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Christian Wetzel
10Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany; and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jochen Herms
6Institute of Neuropathology, Faculty of Medicine, LMU Munich, Munich, Germany;
7SyNergy, University of Munich, Munich, Germany;
8German Center for Neurodegenerative Diseases, Munich, Germany;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Rainer Rupprecht
10Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany; and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Niklas Thon
2German Cancer Consortium, Partner Site Munich, German Cancer Research Center, Munich, Germany;
5Department of Neurosurgery, LMU University Hospital, LMU Munich, Munich, Germany;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Joerg-Christian Tonn
2German Cancer Consortium, Partner Site Munich, German Cancer Research Center, Munich, Germany;
5Department of Neurosurgery, LMU University Hospital, LMU Munich, Munich, Germany;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Claus Belka
2German Cancer Consortium, Partner Site Munich, German Cancer Research Center, Munich, Germany;
3Bavarian Cancer Research Center, Erlangen, Germany;
4Department of Radiation Oncology, LMU University Hospital, LMU Munich, Munich, Germany;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Peter Bartenstein
1Department of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany;
2German Cancer Consortium, Partner Site Munich, German Cancer Research Center, Munich, Germany;
7SyNergy, University of Munich, Munich, Germany;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Louisa von Baumgarten
2German Cancer Consortium, Partner Site Munich, German Cancer Research Center, Munich, Germany;
3Bavarian Cancer Research Center, Erlangen, Germany;
5Department of Neurosurgery, LMU University Hospital, LMU Munich, Munich, Germany;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Maximilian Niyazi
2German Cancer Consortium, Partner Site Munich, German Cancer Research Center, Munich, Germany;
3Bavarian Cancer Research Center, Erlangen, Germany;
4Department of Radiation Oncology, LMU University Hospital, LMU Munich, Munich, Germany;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Marcus Unterrainer
2German Cancer Consortium, Partner Site Munich, German Cancer Research Center, Munich, Germany;
11Department of Radiology, LMU University Hospital, LMU Munich, Munich, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Adrien Holzgreve
1Department of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Article Information

jnumed.122.265247
DOI 
https://doi.org/10.2967/jnumed.122.265247
PubMed 
37536737

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication November 23, 2022
  • Revision received May 31, 2023
  • Published online August 3, 2023.

Article Versions

  • You are currently viewing a previous version of this article (August 3, 2023 - 06:54).
  • View the most recent version of this article
Copyright & Usage 
© 2023 by the Society of Nuclear Medicine and Molecular Imaging. Immediate Open Access: Creative Commons Attribution 4.0 International License (CC BY) allows users to share and adapt with attribution, excluding materials credited to previous publications. License: https://creativecommons.org/licenses/by/4.0/. Details: http://jnm.snmjournals.org/site/misc/permission.xhtml

Author Information

  1. Nathalie L. Albert*,1,2,3,
  2. Debie V. Nelwan*,1,
  3. Daniel F. Fleischmann4,
  4. Stefanie Quach5,
  5. Katharina von Rohr1,
  6. Lena Kaiser1,
  7. Nico Teske2,5,
  8. Lena M. Unterrainer1,
  9. Laura M. Bartos1,
  10. Viktoria C. Ruf6,
  11. Matthias Brendel1,7,8,
  12. Markus J. Riemenschneider9,
  13. Christian Wetzel10,
  14. Jochen Herms6,7,8,
  15. Rainer Rupprecht10,
  16. Niklas Thon2,5,
  17. Joerg-Christian Tonn2,5,
  18. Claus Belka2,3,4,
  19. Peter Bartenstein1,2,7,
  20. Louisa von Baumgarten2,3,5,
  21. Maximilian Niyazi2,3,4,
  22. Marcus Unterrainer2,11 and
  23. Adrien Holzgreve1
  1. 1Department of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany;
  2. 2German Cancer Consortium, Partner Site Munich, German Cancer Research Center, Munich, Germany;
  3. 3Bavarian Cancer Research Center, Erlangen, Germany;
  4. 4Department of Radiation Oncology, LMU University Hospital, LMU Munich, Munich, Germany;
  5. 5Department of Neurosurgery, LMU University Hospital, LMU Munich, Munich, Germany;
  6. 6Institute of Neuropathology, Faculty of Medicine, LMU Munich, Munich, Germany;
  7. 7SyNergy, University of Munich, Munich, Germany;
  8. 8German Center for Neurodegenerative Diseases, Munich, Germany;
  9. 9Department of Neuropathology, Regensburg University Hospital, Regensburg, Germany;
  10. 10Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany; and
  11. 11Department of Radiology, LMU University Hospital, LMU Munich, Munich, Germany
  1. For correspondence or reprints, contact Adrien Holzgreve (adrien.holzgreve{at}med.uni-muenchen.de).
  1. ↵* Contributed equally to this work.

View Full Text

Statistics from Altmetric.com

Cited By...

  • 9 Citations
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • PET-based response assessment criteria for diffuse gliomas (PET RANO 1.0): a report of the RANO group
    Nathalie L Albert, Norbert Galldiks, Benjamin M Ellingson, Martin J van den Bent, Susan M Chang, Francesco Cicone, John de Groot, Eng-Siew Koh, Ian Law, Emilie Le Rhun, Maximilian J Mair, Giuseppe Minniti, Roberta Rudà, Andrew M Scott, Susan C Short, Marion Smits, Bogdana Suchorska, Nelleke Tolboom, Tatjana Traub-Weidinger, Joerg-Christian Tonn, Antoine Verger, Michael Weller, Patrick Y Wen, Matthias Preusser
    The Lancet Oncology 2024 25 1
  • Deciphering sources of PET signals in the tumor microenvironment of glioblastoma at cellular resolution
    Laura M. Bartos, Sabrina V. Kirchleitner, Zeynep Ilgin Kolabas, Stefanie Quach, Alexander Beck, Julia Lorenz, Jens Blobner, Stephan A. Mueller, Selin Ulukaya, Luciano Hoeher, Izabela Horvath, Karin Wind-Mark, Adrien Holzgreve, Viktoria C. Ruf, Lukas Gold, Lea H. Kunze, Sebastian T. Kunte, Philipp Beumers, Ha Eun Park, Melissa Antons, Artem Zatcepin, Nils Briel, Leonie Hoermann, Rebecca Schaefer, Denise Messerer, Peter Bartenstein, Markus J. Riemenschneider, Simon Lindner, Sibylle Ziegler, Jochen Herms, Stefan F. Lichtenthaler, Ali Ertürk, Joerg C. Tonn, Louisa von Baumgarten, Nathalie L. Albert, Matthias Brendel
    Science Advances 2023 9 43
  • Emerging TSPO-PET Radiotracers for Imaging Neuroinflammation: A Critical Analysis
    Grace A. Cumbers, Edward D. Harvey-Latham, Michael Kassiou, Eryn L. Werry, Jonathan J. Danon
    Seminars in Nuclear Medicine 2024 54 6
  • Enhancing predictability of IDH mutation status in glioma patients at initial diagnosis: a comparative analysis of radiomics from MRI, [18F]FET PET, and TSPO PET
    Lena Kaiser, S. Quach, A. J. Zounek, B. Wiestler, A. Zatcepin, A. Holzgreve, A. Bollenbacher, L. M. Bartos, V. C. Ruf, G. Böning, N. Thon, J. Herms, M. J. Riemenschneider, S. Stöcklein, M. Brendel, R. Rupprecht, J. C. Tonn, P. Bartenstein, L. von Baumgarten, S. Ziegler, N. L. Albert
    European Journal of Nuclear Medicine and Molecular Imaging 2024 51 8
  • Potential of TSPO radioligands: Bridging brain tumor diagnostics to the peripheries
    F. Avry, C. Rousseau, F. Kraeber-Bodéré, M. Bourgeois, Nicolas Arlicot
    Biochimie 2024 224
  • Advances in liquid biopsy and virtual biopsy for care of patients with glioma: a narrative review
    Muhammad Awais, Abdul Rehman, Syed Sarmad Bukhari
    Expert Review of Anticancer Therapy 2025 25 5
  • Prätherapeutische TSPO-PET kann die Prognose bei Glioblastom abschätzen
    Angewandte Nuklearmedizin 2024 47 03
  • Prätherapeutische TSPO-PET kann die Prognose bei Glioblastom abschätzen
    Neuroradiologie Scan 2024 14 01
  • Remote Neuroinflammation in Newly Diagnosed Glioblastoma Correlates with Unfavorable Clinical Outcome
    Laura M. Bartos, Stefanie Quach, Valerio Zenatti, Sabrina V. Kirchleitner, Jens Blobner, Karin Wind-Mark, Zeynep Ilgin Kolabas, Selin Ulukaya, Adrien Holzgreve, Viktoria C. Ruf, Lea H. Kunze, Sebastian T. Kunte, Leonie Hoermann, Marlies Härtel, Ha Eun Park, Mattes Groß, Nicolai Franzmeier, Artem Zatcepin, Adrian Zounek, Lena Kaiser, Markus J. Riemenschneider, Robert Perneczky, Boris-Stephan Rauchmann, Sophia Stöcklein, Sibylle Ziegler, Jochen Herms, Ali Ertürk, Joerg C. Tonn, Niklas Thon, Louisa von Baumgarten, Matthias Prestel, Sabina Tahirovic, Nathalie L. Albert, Matthias Brendel
    Clinical Cancer Research 2024 30 20

Article usage

Article usage: August 2023 to April 2025

AbstractFullPdf
Aug 2023791653233
Sep 202315219466
Oct 2023886468153
Nov 202321017568
Dec 202311111561
Jan 202410821561
Feb 20245625636
Mar 20243917559
Apr 20242121067
May 2024419057
Jun 20243913242
Jul 20242019754
Aug 20242319952
Sep 2024810553
Oct 2024277553
Nov 2024227052
Dec 2024156940
Jan 2025135423
Feb 20252112266
Mar 2025148249
Apr 20251610256
PreviousNext
Back to top

In this issue

Journal of Nuclear Medicine: 66 (6)
Journal of Nuclear Medicine
Vol. 66, Issue 6
June 1, 2025
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Complete Issue (PDF)
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on Journal of Nuclear Medicine.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Prognostic Value of TSPO PET Before Radiotherapy in Newly Diagnosed IDH–Wild-Type Glioblastoma
(Your Name) has sent you a message from Journal of Nuclear Medicine
(Your Name) thought you would like to see the Journal of Nuclear Medicine web site.
Citation Tools
Prognostic Value of TSPO PET Before Radiotherapy in Newly Diagnosed IDH–Wild-Type Glioblastoma
Nathalie L. Albert, Debie V. Nelwan, Daniel F. Fleischmann, Stefanie Quach, Katharina von Rohr, Lena Kaiser, Nico Teske, Lena M. Unterrainer, Laura M. Bartos, Viktoria C. Ruf, Matthias Brendel, Markus J. Riemenschneider, Christian Wetzel, Jochen Herms, Rainer Rupprecht, Niklas Thon, Joerg-Christian Tonn, Claus Belka, Peter Bartenstein, Louisa von Baumgarten, Maximilian Niyazi, Marcus Unterrainer, Adrien Holzgreve
Journal of Nuclear Medicine Aug 2023, jnumed.122.265247; DOI: 10.2967/jnumed.122.265247

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Prognostic Value of TSPO PET Before Radiotherapy in Newly Diagnosed IDH–Wild-Type Glioblastoma
Nathalie L. Albert, Debie V. Nelwan, Daniel F. Fleischmann, Stefanie Quach, Katharina von Rohr, Lena Kaiser, Nico Teske, Lena M. Unterrainer, Laura M. Bartos, Viktoria C. Ruf, Matthias Brendel, Markus J. Riemenschneider, Christian Wetzel, Jochen Herms, Rainer Rupprecht, Niklas Thon, Joerg-Christian Tonn, Claus Belka, Peter Bartenstein, Louisa von Baumgarten, Maximilian Niyazi, Marcus Unterrainer, Adrien Holzgreve
Journal of Nuclear Medicine Aug 2023, jnumed.122.265247; DOI: 10.2967/jnumed.122.265247
Twitter logo Facebook logo LinkedIn logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Bookmark this article

Jump to section

  • Article
    • Visual Abstract
    • Abstract
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • CONCLUSION
    • DISCLOSURE
    • ACKNOWLEDGMENTS
    • Footnotes
    • REFERENCES
  • Figures & Data
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

More in this TOC Section

  • Feasibility of Ultra-Low-Activity 18F-FDG PET/CT Imaging Using a Long–Axial-Field-of-View PET/CT System
  • Is Long–Axial-Field-of-View PET/CT Cost-Effective? An International Health–Economic Analysis
  • Multicycle Dosimetric Behavior and Dose–Effect Relationships in [177Lu]Lu-DOTATATE Peptide Receptor Radionuclide Therapy
Show more Clinical Investigation

Similar Articles

Keywords

  • prognostication
  • survival
  • glioma
SNMMI

© 2025 SNMMI

Powered by HighWire