Therapy-Related Myeloid Neoplasms After [177Lu]Lu-PSMA Therapy in Patients with Metastatic Castration-Resistant Prostate Cancer: A Case Series

Michal Eifer; Duncan E.K. Sutherland; Isaac Goncalves; James P. Buteau; Lewis Au; Arun A. Azad; Louise Emmett; Grace Kong; Louise Kostos; Aravind S. Ravi Kumar; Edmond M. Kwan; Elizabeth Medhurst; Shahneen Sandhu; Ben Tran; Alexander W. Wyatt; Michael S. Hofman

doi:10.2967/jnumed.124.268640

Research ArticleClinical Investigation

Therapy-Related Myeloid Neoplasms After [¹⁷⁷Lu]Lu-PSMA Therapy in Patients with Metastatic Castration-Resistant Prostate Cancer: A Case Series

Michal Eifer, Duncan E.K. Sutherland, Isaac Goncalves, James P. Buteau, Lewis Au, Arun A. Azad, Louise Emmett, Grace Kong, Louise Kostos, Aravind S. Ravi Kumar, Edmond M. Kwan, Elizabeth Medhurst, Shahneen Sandhu, Ben Tran, Alexander W. Wyatt and Michael S. Hofman

Journal of Nuclear Medicine April 2025, 66 (4) 579-584; DOI: https://doi.org/10.2967/jnumed.124.268640

Michal Eifer

1Molecular Imaging and Therapeutic Nuclear Medicine, Cancer Imaging, Prostate Cancer Theranostics and Imaging Centre of Excellence, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;

2Department of Diagnostic Imaging, Chaim Sheba Medical Center, Ramat Gan, Israel, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel;

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Duncan E.K. Sutherland

1Molecular Imaging and Therapeutic Nuclear Medicine, Cancer Imaging, Prostate Cancer Theranostics and Imaging Centre of Excellence, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;

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Isaac Goncalves

3Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia;

4Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;

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James P. Buteau

1Molecular Imaging and Therapeutic Nuclear Medicine, Cancer Imaging, Prostate Cancer Theranostics and Imaging Centre of Excellence, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;

3Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia;

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Lewis Au

3Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia;

4Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;

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Arun A. Azad

3Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia;

4Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;

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Louise Emmett

5Department of Theranostics and Nuclear Medicine, St. Vincent’s Hospital, Sydney, New South Wales, Australia, and Faculty of Medicine, UNSW Sydney, Sydney, New South Wales, Australia; and

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Grace Kong

1Molecular Imaging and Therapeutic Nuclear Medicine, Cancer Imaging, Prostate Cancer Theranostics and Imaging Centre of Excellence, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;

3Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia;

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Louise Kostos

3Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia;

4Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;

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Aravind S. Ravi Kumar

1Molecular Imaging and Therapeutic Nuclear Medicine, Cancer Imaging, Prostate Cancer Theranostics and Imaging Centre of Excellence, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;

3Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia;

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Edmond M. Kwan

6Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada

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Elizabeth Medhurst

1Molecular Imaging and Therapeutic Nuclear Medicine, Cancer Imaging, Prostate Cancer Theranostics and Imaging Centre of Excellence, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;

3Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia;

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Shahneen Sandhu

3Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia;

4Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;

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Ben Tran

3Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia;

4Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;

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Alexander W. Wyatt

6Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada

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Michael S. Hofman

1Molecular Imaging and Therapeutic Nuclear Medicine, Cancer Imaging, Prostate Cancer Theranostics and Imaging Centre of Excellence, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;

3Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia;

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Therapy-Related Myeloid Neoplasms After [¹⁷⁷Lu]Lu-PSMA Therapy in Patients with Metastatic Castration-Resistant Prostate Cancer: A Case Series

Journal of Nuclear Medicine Apr 2025, 66 (4) 579-584; DOI: 10.2967/jnumed.124.268640

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Therapy-Related Myeloid Neoplasms After [¹⁷⁷Lu]Lu-PSMA Therapy in Patients with Metastatic Castration-Resistant Prostate Cancer: A Case Series

Journal of Nuclear Medicine Apr 2025, 66 (4) 579-584; DOI: 10.2967/jnumed.124.268640

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[177Lu]Lu-PSMA
t-MN
mCRPC

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