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Research ArticleClinical Investigation

PSMA-Guided Metastasis-Directed Therapy for Oligometastatic Renal Cell Carcinoma: The Proof-of-Concept PEDESTAL Study

Cristian Udovicich, Mathias Bressel, Jamil Manji, Muhammad Ali, Lewis Au, Arun A. Azad, James P. Buteau, Sarat Chander, David Chang, Renu Eapen, Nathan Lawrentschuk, Sidney M. Levy, Daniel Moon, Declan G. Murphy, Marlon Perera, Mark Shaw, Lavinia Spain, Ben Tran, Michael S. Hofman and Shankar Siva
Journal of Nuclear Medicine April 2025, 66 (4) 531-536; DOI: https://doi.org/10.2967/jnumed.124.268639
Cristian Udovicich
1Department of Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;
2Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia;
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Mathias Bressel
2Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia;
3Centre for Biostatistics and Clinical Trials, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;
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Jamil Manji
1Department of Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;
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Muhammad Ali
1Department of Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;
2Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia;
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Lewis Au
2Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia;
4Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;
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Arun A. Azad
2Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia;
4Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;
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James P. Buteau
2Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia;
5Prostate Theranostics and Imaging Centre of Excellence, Molecular Imaging and Therapeutic Nuclear Medicine, Cancer Imaging, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;
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Sarat Chander
1Department of Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;
2Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia;
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David Chang
1Department of Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;
2Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia;
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Renu Eapen
6Division of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;
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Nathan Lawrentschuk
6Division of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;
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Sidney M. Levy
2Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia;
7Molecular Imaging and Therapeutic Nuclear Medicine, Peter MacCallum Cancer Centre Parkville, Melbourne, Victoria, Australia;
8Department of Nuclear Medicine, Royal Melbourne Hospital Parkville, Melbourne, Victoria, Australia; and
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Daniel Moon
6Division of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;
9Royal Melbourne Clinical School, University of Melbourne, Melbourne, Victoria, Australia
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Declan G. Murphy
6Division of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;
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Marlon Perera
6Division of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;
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Mark Shaw
1Department of Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;
2Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia;
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Lavinia Spain
2Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia;
4Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;
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Ben Tran
2Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia;
4Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;
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Michael S. Hofman
2Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia;
5Prostate Theranostics and Imaging Centre of Excellence, Molecular Imaging and Therapeutic Nuclear Medicine, Cancer Imaging, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;
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Shankar Siva
1Department of Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;
2Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia;
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Article Information

vol. 66 no. 4 531-536
DOI 
https://doi.org/10.2967/jnumed.124.268639
PubMed 
39978809

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication October 1, 2024
  • Accepted for publication January 17, 2025
  • Published online April 1, 2025.

Article Versions

  • previous version (February 20, 2025 - 08:20).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2025 by the Society of Nuclear Medicine and Molecular Imaging.

Author Information

  1. Cristian Udovicich1,2,
  2. Mathias Bressel2,3,
  3. Jamil Manji1,
  4. Muhammad Ali1,2,
  5. Lewis Au2,4,
  6. Arun A. Azad2,4,
  7. James P. Buteau2,5,
  8. Sarat Chander1,2,
  9. David Chang1,2,
  10. Renu Eapen6,
  11. Nathan Lawrentschuk6,
  12. Sidney M. Levy2,7,8,
  13. Daniel Moon6,9,
  14. Declan G. Murphy6,
  15. Marlon Perera6,
  16. Mark Shaw1,2,
  17. Lavinia Spain2,4,
  18. Ben Tran2,4,
  19. Michael S. Hofman2,5 and
  20. Shankar Siva1,2
  1. 1Department of Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;
  2. 2Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia;
  3. 3Centre for Biostatistics and Clinical Trials, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;
  4. 4Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;
  5. 5Prostate Theranostics and Imaging Centre of Excellence, Molecular Imaging and Therapeutic Nuclear Medicine, Cancer Imaging, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;
  6. 6Division of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;
  7. 7Molecular Imaging and Therapeutic Nuclear Medicine, Peter MacCallum Cancer Centre Parkville, Melbourne, Victoria, Australia;
  8. 8Department of Nuclear Medicine, Royal Melbourne Hospital Parkville, Melbourne, Victoria, Australia; and
  9. 9Royal Melbourne Clinical School, University of Melbourne, Melbourne, Victoria, Australia
  1. For correspondence or reprints, contact Shankar Siva (shankar.siva{at}petermac.org).
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PSMA-Guided Metastasis-Directed Therapy for Oligometastatic Renal Cell Carcinoma: The Proof-of-Concept PEDESTAL Study
Cristian Udovicich, Mathias Bressel, Jamil Manji, Muhammad Ali, Lewis Au, Arun A. Azad, James P. Buteau, Sarat Chander, David Chang, Renu Eapen, Nathan Lawrentschuk, Sidney M. Levy, Daniel Moon, Declan G. Murphy, Marlon Perera, Mark Shaw, Lavinia Spain, Ben Tran, Michael S. Hofman, Shankar Siva
Journal of Nuclear Medicine Apr 2025, 66 (4) 531-536; DOI: 10.2967/jnumed.124.268639

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PSMA-Guided Metastasis-Directed Therapy for Oligometastatic Renal Cell Carcinoma: The Proof-of-Concept PEDESTAL Study
Cristian Udovicich, Mathias Bressel, Jamil Manji, Muhammad Ali, Lewis Au, Arun A. Azad, James P. Buteau, Sarat Chander, David Chang, Renu Eapen, Nathan Lawrentschuk, Sidney M. Levy, Daniel Moon, Declan G. Murphy, Marlon Perera, Mark Shaw, Lavinia Spain, Ben Tran, Michael S. Hofman, Shankar Siva
Journal of Nuclear Medicine Apr 2025, 66 (4) 531-536; DOI: 10.2967/jnumed.124.268639
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  • metastasectomy
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  • SBRT
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