[18F]MK-6240 Radioligand Delivery Indices as Surrogates of Cerebral Perfusion: Bias and Correlation Against [15O]Water

Jessie Fanglu Fu; Meher R. Juttukonda; Arun Garimella; Andrew N. Salvatore; Cristina Lois; Anthony Ranasinghe; Nikos Efthimiou; Hasan Sari; William Aye; Nicolas J. Guehl; Georges El Fakhri; Keith A. Johnson; Bradford C. Dickerson; David Izquierdo-Garcia; Ciprian Catana; Julie C. Price

doi:10.2967/jnumed.124.268701

Research ArticleClinical Investigation

[¹⁸F]MK-6240 Radioligand Delivery Indices as Surrogates of Cerebral Perfusion: Bias and Correlation Against [¹⁵O]Water

Jessie Fanglu Fu, Meher R. Juttukonda, Arun Garimella, Andrew N. Salvatore, Cristina Lois, Anthony Ranasinghe, Nikos Efthimiou, Hasan Sari, William Aye, Nicolas J. Guehl, Georges El Fakhri, Keith A. Johnson, Bradford C. Dickerson, David Izquierdo-Garcia, Ciprian Catana and Julie C. Price

Journal of Nuclear Medicine March 2025, 66 (3) 410-417; DOI: https://doi.org/10.2967/jnumed.124.268701

Jessie Fanglu Fu

1Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts;

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Meher R. Juttukonda

1Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts;

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Arun Garimella

1Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts;

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Andrew N. Salvatore

1Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts;

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Cristina Lois

2Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts;

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Anthony Ranasinghe

1Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts;

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Nikos Efthimiou

1Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts;

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Hasan Sari

1Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts;

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William Aye

1Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts;

3New Zealand Brain Research Institute, Christchurch Central City, Canterbury, New Zealand; and

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Nicolas J. Guehl

2Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts;

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Georges El Fakhri

2Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts;

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Keith A. Johnson

2Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts;

4Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts

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Bradford C. Dickerson

1Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts;

4Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts

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David Izquierdo-Garcia

1Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts;

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Ciprian Catana

1Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts;

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Julie C. Price

1Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts;

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Vol. 66, Issue 3

March 1, 2025

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[¹⁸F]MK-6240 Radioligand Delivery Indices as Surrogates of Cerebral Perfusion: Bias and Correlation Against [¹⁵O]Water

Journal of Nuclear Medicine Mar 2025, 66 (3) 410-417; DOI: 10.2967/jnumed.124.268701

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[¹⁸F]MK-6240 Radioligand Delivery Indices as Surrogates of Cerebral Perfusion: Bias and Correlation Against [¹⁵O]Water

Journal of Nuclear Medicine Mar 2025, 66 (3) 410-417; DOI: 10.2967/jnumed.124.268701

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[18F]MK-6240
PET
tau
perfusion

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