Exploring the Flare Phenomenon in Patients with Castration-Resistant Prostate Cancer: Enzalutamide-Induced PSMA Upregulation Observed on PSMA PET

Suzanne van der Gaag; André N. Vis; Imke H. Bartelink; Josephina C.C. Koppes; Marina Hodolic; Harry Hendrikse; Daniela E. Oprea-Lager

doi:10.2967/jnumed.124.268340

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Exploring the Flare Phenomenon in Patients with Castration-Resistant Prostate Cancer: Enzalutamide-Induced PSMA Upregulation Observed on PSMA PET

Suzanne van der Gaag, André N. Vis, Imke H. Bartelink, Josephina C.C. Koppes, Marina Hodolic, Harry Hendrikse and Daniela E. Oprea-Lager

Journal of Nuclear Medicine March 2025, 66 (3) 373-376; DOI: https://doi.org/10.2967/jnumed.124.268340

Suzanne van der Gaag

1Department of Radiology and Nuclear Medicine, Amsterdam UMC Location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands;

2Imaging and Biomarkers, Cancer Center Amsterdam, Amsterdam, The Netherlands;

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André N. Vis

3Department of Urology, Prostate Cancer Network Amsterdam, Amsterdam UMC Location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands;

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Imke H. Bartelink

2Imaging and Biomarkers, Cancer Center Amsterdam, Amsterdam, The Netherlands;

4Department of Clinical Pharmacology and Pharmacy, Amsterdam UMC Location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands; and

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Josephina C.C. Koppes

1Department of Radiology and Nuclear Medicine, Amsterdam UMC Location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands;

2Imaging and Biomarkers, Cancer Center Amsterdam, Amsterdam, The Netherlands;

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Marina Hodolic

5Nuclear Medicine Department, Faculty of Medicine and Dentistry, Palacký University Olomouc, Olomouc, Czech Republic

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Harry Hendrikse

1Department of Radiology and Nuclear Medicine, Amsterdam UMC Location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands;

2Imaging and Biomarkers, Cancer Center Amsterdam, Amsterdam, The Netherlands;

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Daniela E. Oprea-Lager

1Department of Radiology and Nuclear Medicine, Amsterdam UMC Location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands;

2Imaging and Biomarkers, Cancer Center Amsterdam, Amsterdam, The Netherlands;

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Journal of Nuclear Medicine

Vol. 66, Issue 3

March 1, 2025

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Exploring the Flare Phenomenon in Patients with Castration-Resistant Prostate Cancer: Enzalutamide-Induced PSMA Upregulation Observed on PSMA PET

Suzanne van der Gaag, André N. Vis, Imke H. Bartelink, Josephina C.C. Koppes, Marina Hodolic, Harry Hendrikse, Daniela E. Oprea-Lager

Journal of Nuclear Medicine Mar 2025, 66 (3) 373-376; DOI: 10.2967/jnumed.124.268340

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Exploring the Flare Phenomenon in Patients with Castration-Resistant Prostate Cancer: Enzalutamide-Induced PSMA Upregulation Observed on PSMA PET

Suzanne van der Gaag, André N. Vis, Imke H. Bartelink, Josephina C.C. Koppes, Marina Hodolic, Harry Hendrikse, Daniela E. Oprea-Lager

Journal of Nuclear Medicine Mar 2025, 66 (3) 373-376; DOI: 10.2967/jnumed.124.268340

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Keywords

prostate-specific membrane antigen
enzalutamide
androgen receptor–targeting agent
ARTA
prostate cancer
flare phenomenon

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