RadioFlow Cytometry Reveals That [18F]FDG Uptake in K-RAS Lung Cancer Is Driven by Immune Cells: An Analysis on a Single-Cell Level

Chrysoula Vraka; Monika Homolya; Öykü Özer; Andreas Spittler; Michael Machtinger; Herwig P. Moll; Emilio Casanova; Claudia Kuntner; Stefan Grünert; Marcus Hacker; Cécile Philippe

doi:10.2967/jnumed.124.268799

Research ArticleFEATURED BASIC SCIENCE ARTICLE

RadioFlow Cytometry Reveals That [¹⁸F]FDG Uptake in K-RAS Lung Cancer Is Driven by Immune Cells: An Analysis on a Single-Cell Level

Chrysoula Vraka, Monika Homolya, Öykü Özer, Andreas Spittler, Michael Machtinger, Herwig P. Moll, Emilio Casanova, Claudia Kuntner, Stefan Grünert, Marcus Hacker and Cécile Philippe

Journal of Nuclear Medicine February 2025, 66 (2) 215-222; DOI: https://doi.org/10.2967/jnumed.124.268799

Chrysoula Vraka

1Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria;

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Monika Homolya

2Institute of Pharmacology, Center of Physiology and Pharmacology and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria;

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Öykü Özer

1Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria;

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Andreas Spittler

3Core Facility Flow Cytometry and Surgical Research Laboratories, Medical University of Vienna, Vienna, Austria;

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Michael Machtinger

2Institute of Pharmacology, Center of Physiology and Pharmacology and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria;

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Herwig P. Moll

2Institute of Pharmacology, Center of Physiology and Pharmacology and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria;

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Emilio Casanova

2Institute of Pharmacology, Center of Physiology and Pharmacology and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria;

4Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria; and

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Claudia Kuntner

1Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria;

5Medical Imaging Cluster, Medical University of Vienna, Vienna, Austria

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Stefan Grünert

1Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria;

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Marcus Hacker

1Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria;

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Cécile Philippe

1Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria;

5Medical Imaging Cluster, Medical University of Vienna, Vienna, Austria

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Journal of Nuclear Medicine

Vol. 66, Issue 2

February 1, 2025

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RadioFlow Cytometry Reveals That [¹⁸F]FDG Uptake in K-RAS Lung Cancer Is Driven by Immune Cells: An Analysis on a Single-Cell Level

Chrysoula Vraka, Monika Homolya, Öykü Özer, Andreas Spittler, Michael Machtinger, Herwig P. Moll, Emilio Casanova, Claudia Kuntner, Stefan Grünert, Marcus Hacker, Cécile Philippe

Journal of Nuclear Medicine Feb 2025, 66 (2) 215-222; DOI: 10.2967/jnumed.124.268799

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RadioFlow Cytometry Reveals That [¹⁸F]FDG Uptake in K-RAS Lung Cancer Is Driven by Immune Cells: An Analysis on a Single-Cell Level

Chrysoula Vraka, Monika Homolya, Öykü Özer, Andreas Spittler, Michael Machtinger, Herwig P. Moll, Emilio Casanova, Claudia Kuntner, Stefan Grünert, Marcus Hacker, Cécile Philippe

Journal of Nuclear Medicine Feb 2025, 66 (2) 215-222; DOI: 10.2967/jnumed.124.268799

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Keywords

[18F]FDG
immunometabolism
radioactive cell sorting
K-RAS lung cancer
radioFlow

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RadioFlow Cytometry Reveals That [¹⁸F]FDG Uptake in K-RAS Lung Cancer Is Driven by Immune Cells: An Analysis on a Single-Cell Level

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