Journal of Nuclear Medicine: 66 (2)

February 1, 2025; Volume 66,Issue 2

Discussions with Leaders

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From Scientist to Analyst to Strategist
Aharon (Ronny) Gal, Ken Herrmann and Johannes Czernin

Journal of Nuclear Medicine February 1, 2025, 66 (2) 163-165; DOI: https://doi.org/10.2967/jnumed.124.269177

The State of the Art

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Dosimetry Software for Theranostic Applications: Current Capabilities and Future Prospects
Adam L. Kesner, Julia Brosch-Lenz, Jonathan Gear and Michael Lassmann

Journal of Nuclear Medicine February 1, 2025, 66 (2) 166-172; DOI: https://doi.org/10.2967/jnumed.124.268998

Continuing Education

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Large Language Models and Large Multimodal Models in Medical Imaging: A Primer for Physicians
Tyler J. Bradshaw, Xin Tie, Joshua Warner, Junjie Hu, Quanzheng Li and Xiang Li

Journal of Nuclear Medicine February 1, 2025, 66 (2) 173-182; DOI: https://doi.org/10.2967/jnumed.124.268072

Is It Really Happening?

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Is the Clinical Implementation of In-House Artificial Intelligence–Developed Algorithms Happening?
David Gergely Kovacs, Claes Nøhr Ladefoged, Jacob Bak Rosenkjær, Fatima Mawassi, Line Akiti Hingelberg, Anna Olga Aaskilde Laursen, Barbara Malene Fischer and Flemming Littrup Andersen

Journal of Nuclear Medicine February 1, 2025, 66 (2) 183-185; DOI: https://doi.org/10.2967/jnumed.124.268156

Editorial

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Diagnostic Radiopharmaceuticals: A Sustainable Path to the Improvement of Patient Care
Andrei Gafita, Andrew R. Menard and Lilja B. Solnes

Journal of Nuclear Medicine February 1, 2025, 66 (2) 186; DOI: https://doi.org/10.2967/jnumed.124.268608

Oncology

Clinical
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  Borderline Findings in O-(2-[¹⁸F]-Fluoroethyl)-l-Tyrosine PET of Patients with Suspected Glioma Relapse: Role in Clinical Practice
  Karl-Josef Langen, Gabriele Stoffels, Christian P. Filss, Martin Kocher, Christoph Lerche, Michael Sabel, Marion Rapp, Hosai Noltemeier, Jan-Michael Werner, Garry Ceccon, Michael M. Wollring, Jurij Rosen, Joachim P. Steinbach, Elke Hattingen, Martin R. Weinzierl, Michael Stoffel, Hans Clusmann, N. Jon Shah, Felix M. Mottaghy, Norbert Galldiks and Philipp Lohmann
  
  Journal of Nuclear Medicine February 1, 2025, 66 (2) 187-193; DOI: https://doi.org/10.2967/jnumed.124.268768
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  Intrapatient 16α-[¹⁸F]Fluoro-17β-Estradiol PET Heterogeneity as a Prognostic Factor for Endocrine Therapy Response and Survival in Patients with Estrogen Receptor–Positive Metastatic Breast Cancer
  Jasper J.L. van Geel, Jasmine Moustaquim, Jorianne Boers, Sjoerd G. Elias, Esther M.M. Smeets, Jelijn J. Knip, Andor W.J.M. Glaudemans, Erik F.J. de Vries, Geke A.P. Hospers, Michel van Kruchten, Marcel Stokkel, Daniela E. Oprea-Lager, Willemien C. Menke-van der Houven van Oordt, Elisabeth G.E. de Vries and Carolina P. Schröder; on behalf of the IMPACT-Metastatic Breast Consortium
  
  Journal of Nuclear Medicine February 1, 2025, 66 (2) 194-200; DOI: https://doi.org/10.2967/jnumed.124.268984
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  Head-to-Head Comparison of [⁶⁸Ga]Ga-NOTA-RM26 and [¹⁸F]FDG PET/CT in Patients with Gastrointestinal Stromal Tumors: A Prospective Study
  Rongxi Wang, Weiming Kang, Zhen Liu, Yumin Zheng, Huimin Sui, Linlin Li, Jiarou Wang, Jialin Xiang, Xingtong Peng, Xiaoyuan Chen, Zhaohui Zhu and Jingjing Zhang
  
  Journal of Nuclear Medicine February 1, 2025, 66 (2) 201-206; DOI: https://doi.org/10.2967/jnumed.124.267810
- INVITED PERSPECTIVE
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    Gastrin-Releasing Peptide Receptor Imaging and Therapy in the Era of Personalized Medicine
    Clément Morgat, Andrei Iagaru and Elif Hindié
    
    Journal of Nuclear Medicine February 1, 2025, 66 (2) 207-208; DOI: https://doi.org/10.2967/jnumed.124.268861
- BRIEF COMMUNICATION
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    PET-Based Risk Stratification in Primary Mediastinal B-Cell Lymphoma: A Comparative Analysis of Different Segmentation Methods in the IELSG37 Trial Patient Cohort
    Luca Ceriani, Lisa Milan, Maria Cristina Pirosa, Maurizio Martelli, Teresa Ruberto, Luciano Cascione, Peter W.M. Johnson, Andrew J. Davies, Giovannino Ciccone and Emanuele Zucca
    
    Journal of Nuclear Medicine February 1, 2025, 66 (2) 209-214; DOI: https://doi.org/10.2967/jnumed.124.268874
Basic
- FEATURED BASIC SCIENCE ARTICLE
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    RadioFlow Cytometry Reveals That [¹⁸F]FDG Uptake in K-RAS Lung Cancer Is Driven by Immune Cells: An Analysis on a Single-Cell Level
    Chrysoula Vraka, Monika Homolya, Öykü Özer, Andreas Spittler, Michael Machtinger, Herwig P. Moll, Emilio Casanova, Claudia Kuntner, Stefan Grünert, Marcus Hacker and Cécile Philippe
    
    Journal of Nuclear Medicine February 1, 2025, 66 (2) 215-222; DOI: https://doi.org/10.2967/jnumed.124.268799

Theranostics

Clinical
- Open Access
  Prospective Head-to-Head Comparison of ¹⁸F-PSMA PET/CT and ¹⁸F-NaF PET/CT for Assessing Bone Metastases in 160 Patients with Newly Diagnosed High-Risk Prostate Cancer
  Claus Madsen, Dan Fuglø, Maria Pedersen, Rikke Broholm, Peter B. Østergren, Rasmus Bisbjerg, Per Kongsted, Kayalvili Nielsen, Christian Haarmark and Helle Zacho
  
  Journal of Nuclear Medicine February 1, 2025, 66 (2) 223-229; DOI: https://doi.org/10.2967/jnumed.124.268275
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  Diuresis During ¹⁸F-Flotufolastat (rhPSMA-7.3) PET/CT Improves Recurrence Detection After Prostatectomy: A Prospective Phase II Trial
  Ismaheel O. Lawal, Aliza Mushtaq, Ashesh B. Jani, Manali Rupji, Vishal R. Dhere, Sagar A. Patel, Mehmet A. Bilen, Pretesh R. Patel, Nikhil T. Sebastian, Jeffrey M. Switchenko, David M. Schuster and Charles Marcus
  
  Journal of Nuclear Medicine February 1, 2025, 66 (2) 230-237; DOI: https://doi.org/10.2967/jnumed.124.268574
- FEATURED ARTICLE OF THE MONTH
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    ¹⁷⁷Lu-DOTATATE Plus Capecitabine Versus ¹⁷⁷Lu-DOTATATE Alone in Patients with Advanced Grade 1/2 Gastroenteropancreatic Neuroendocrine Tumors (LuCAP): A Randomized, Phase 2 Trial
    Swayamjeet Satapathy, Piyush Aggarwal, Ashwani Sood, Kunal R. Chandekar, Chandan K. Das, Rajesh Gupta, Divya Khosla, Namrata Das, Rakesh Kapoor, Rajender Kumar, Harmandeep Singh, Jaya Shukla, Ajay Kumar and Bhagwant Rai Mittal
    
    Journal of Nuclear Medicine February 1, 2025, 66 (2) 238-244; DOI: https://doi.org/10.2967/jnumed.124.268617
- BRIEF COMMUNICATION
  - Open Access
    Comprehensive Characterization via Molecular Imaging, Longitudinal Multisite Sampling, and Autoptic Work-up in Advanced Small Cell Lung Cancer Undergoing SSTR-Directed Radiopharmaceutical Therapy
    Johanna S. Enke, Nic G. Reitsam, Sebastian Dintner, Friederike Liesche-Starnecker, Tina Schaller, Josua A. Decker, Angela Langer, Eva Sipos, Ana Antic Nikolic, Thomas Kröncke, Martin Trepel, Constantin Lapa, Rainer Claus, Bruno Märkl and Ralph A. Bundschuh
    
    Journal of Nuclear Medicine February 1, 2025, 66 (2) 245-249; DOI: https://doi.org/10.2967/jnumed.124.268513
Basic
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  Preclinical Evaluation of ⁶⁸Ga/¹⁷⁷Lu-Labeled FAP-Targeted Peptide for Tumor Radiopharmaceutical Imaging and Therapy
  Rang Wang, Mingxing Huang, Weichen Wang, Mufeng Li, Yingwei Wang and Rong Tian
  
  Journal of Nuclear Medicine February 1, 2025, 66 (2) 250-256; DOI: https://doi.org/10.2967/jnumed.124.268689

Radiobiology/Dosimetry

Clinical
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  Safety, Biodistribution, and Radiation Dosimetry of the ⁶⁸Ga-Labeled Minigastrin Analog DOTA-MGS5 in Patients with Advanced Medullary Thyroid Cancer and Other Neuroendocrine Tumors
  Elisabeth von Guggenberg, Gianpaolo di Santo, Christian Uprimny, Steffen Bayerschmidt, Boris Warwitz, Anton A. Hörmann, Taraneh S. Zavvar, Christine Rangger, Clemens Decristoforo, Anna Sviridenko, Bernhard Nilica, Giulia Santo and Irene J. Virgolini
  
  Journal of Nuclear Medicine February 1, 2025, 66 (2) 257-263; DOI: https://doi.org/10.2967/jnumed.124.268877

Cardiovascular

Clinical
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  PET/CT with Myocardial Blood Flow Assessment Is Prognostic of Cardiac Allograft Vasculopathy Progression and Clinical Outcomes
  Nikil Prasad, Erin Harris, Ersilia M. DeFilippis, Gabriel Sayer, Margarita Chernovolenko, Paolo C. Colombo, Justin Fried, David Bae, Kyung Taek Oh, Jayant Raikhelkar, Sambhavi Sneha Kumar, Melana Yuzefpolskaya, Veli K. Topkara, Michelle Castillo, Elaine Y. Lam, Farhana Latif, Koji Takeda, Nir Uriel, Andrew J. Einstein and Kevin J. Clerkin
  
  Journal of Nuclear Medicine February 1, 2025, 66 (2) 264-270; DOI: https://doi.org/10.2967/jnumed.124.268713
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  Cardiac Presynaptic Sympathetic Nervous Function Evaluated by Cardiac PET in Patients with Chronotropic Incompetence Without Heart Failure
  Toshihiko Goto, Shohei Kikuchi, Yomei Sakurai, Yoshiro Tsuruta, Kento Mori, Tatsuya Mizoguchi, Yu Kawada, Yasuhiro Shintani, Masashi Yokoi, Sayuri Yamabe, Tsuyoshi Ito, Shuichi Kitada, Hidekatsu Fukuta, Kyoko Matsui, Hitomi Narita, Sumire Nankou and Yoshihiro Seo
  
  Journal of Nuclear Medicine February 1, 2025, 66 (2) 271-276; DOI: https://doi.org/10.2967/jnumed.124.268638

Neurology

Clinical
- Open Access
  In Vivo Head-to-Head Comparison of [¹⁸F]GTP1 with [¹⁸F]MK-6240 and [¹⁸F]PI-2620 in Alzheimer Disease
  Emily Olafson, Matteo Tonietto, Gregory Klein, Edmond Teng, Andrew W. Stephens, David S. Russell, Karen Pickthorn and Sandra Sanabria Bohorquez
  
  Journal of Nuclear Medicine February 1, 2025, 66 (2) 277-285; DOI: https://doi.org/10.2967/jnumed.124.268623
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  Longitudinal Trajectory of Dopamine and Serotonin Transporters in Parkinson Disease
  Yujin Song, Jae-Hyeok Lee, Han-Kyeol Kim, Jae Hoon Lee, Young Hoon Ryu, Han Soo Yoo and Chul Hyoung Lyoo
  
  Journal of Nuclear Medicine February 1, 2025, 66 (2) 286-292; DOI: https://doi.org/10.2967/jnumed.124.268365
Basic
- Open Access
  Imaging Demyelinated Axons After Spinal Cord Injuries with PET Tracer [¹⁸F]3F4AP
  Karla M. Ramos-Torres, Sara Conti, Yu-Peng Zhou, Amal Tiss, Celine Caravagna, Kazue Takahashi, Miao He, Moses Q. Wilks, Sophie Eckl, Yang Sun, Jason Biundo, Kuang Gong, Zhigang He, Clas Linnman and Pedro Brugarolas
  
  Journal of Nuclear Medicine February 1, 2025, 66 (2) 293-301; DOI: https://doi.org/10.2967/jnumed.124.268242

Radiochemistry/Radiopharmaceuticals

Clinical
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  First-in-Human Study of [¹¹C]NCGG401 for Imaging Colony-Stimulating Factor 1 Receptors in the Brain
  Aya Ogata, Hiroshi Ikenuma, Fumihiko Yasuno, Takashi Nihashi, Saori Hattori, Yayoi Sato, Masanori Ichise, Kengo Ito, Takashi Kato and Yasuyuki Kimura
  
  Journal of Nuclear Medicine February 1, 2025, 66 (2) 302-308; DOI: https://doi.org/10.2967/jnumed.124.268699

AI/Advanced Image Analysis

Clinical
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  Preserved Serotonin Transporter Availability in Parkinson Disease Measured with Either [¹¹C]MADAM or [¹¹C]DASB: A Study Including 2 Separate Cohorts of Nondepressed Patients
  Minyoung Oh, Joachim Brumberg, Vesna Sossi and Andrea Varrone
  
  Journal of Nuclear Medicine February 1, 2025, 66 (2) 309-314; DOI: https://doi.org/10.2967/jnumed.124.268233

Physics and Instrumentation

Basic
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  A Method for Validating PET and SPECT Cameras for Quantitative Clinical Imaging Trials Using Novel Radionuclides
  Dale L. Bailey, Kathy P. Willowson, Graeme O’Keefe, Steven Goodman, Shaun Patford, George McGill, David A. Pattison and Andrew M. Scott; on behalf of the I-FIRST investigators and ARTnet
  
  Journal of Nuclear Medicine February 1, 2025, 66 (2) 315-322; DOI: https://doi.org/10.2967/jnumed.124.268578
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  Total-Body PET System Designs with Axial and Transverse Gaps: A Study of Lesion Quantification and Detectability
  Min Gao, Margaret E. Daube-Witherspoon, Joel S. Karp and Suleman Surti
  
  Journal of Nuclear Medicine February 1, 2025, 66 (2) 323-329; DOI: https://doi.org/10.2967/jnumed.124.267769

The Illustrated Post

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Redifferentiation of a RET-Fusion, Radioiodine-Refractory, Differentiated Thyroid Cancer with Selpercatinib: Flip-Flop Between [¹⁸F]FDG PET/CT and ¹³¹I Posttreatment Scanning
Floriane Barbry, Benjamin Chevalier, Amandine Beron, Georges Lion, Samuel Boury, Camille Marciniak, Clio Baillet, Christine Do Cao and Arnaud Jannin

Journal of Nuclear Medicine February 1, 2025, 66 (2) 330; DOI: https://doi.org/10.2967/jnumed.124.268539

Letter to the Editor

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Maintaining the Evidence for In Vivo Brain Estrogen Receptor Density by Neuroendocrine Aging and Relationships with Cognition and Symptomatology
Lisa Mosconi, Matilde Nerattini, Valentina Berti, Dawn C. Matthews, Caroline Andy, Schantel Williams, Matthew Fink, Alberto Pupi and Roberta Diaz Brinton

Journal of Nuclear Medicine February 1, 2025, 66 (2) 331-332; DOI: https://doi.org/10.2967/jnumed.124.269268

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Table of Contents

Discussions with Leaders

The State of the Art

Continuing Education

Is It Really Happening?

Editorial

Oncology

Clinical

INVITED PERSPECTIVE

BRIEF COMMUNICATION

Basic

FEATURED BASIC SCIENCE ARTICLE

Theranostics

Clinical

FEATURED ARTICLE OF THE MONTH

BRIEF COMMUNICATION

Basic

Radiobiology/Dosimetry

Clinical

Cardiovascular

Clinical

Neurology

Clinical

Basic

Radiochemistry/Radiopharmaceuticals

Clinical

AI/Advanced Image Analysis

Clinical

Physics and Instrumentation

Basic

The Illustrated Post

Letter to the Editor

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