Article Figures & Data
Figures
- FIGURE 1.
Autoradiography images showing binding of [18F]flortaucipir, [18F]MK6240, and [18F]PI2620 in prefrontal cortex, hippocampus, and cerebellum (A) and in whole-brain hemisphere (B) of control and AD brains. CN = control.
- FIGURE 2.
(A–C) Total binding of [18F]flortaucipir, [18F]MK6240, and [18F]PI2620 in prefrontal cortex (A), hippocampus (B), and cerebellum gray matter (C). (D and E) Prefrontal cortex–to–cerebellum (D) and hippocampus-to-cerebellum (E) ratios. Significant differences between control and AD tissues were present for binding of [18F]flortaucipir (n = 12), [18F]MK6240 (n = 12), and [18F]PI2620 (n = 12) in prefrontal cortex and hippocampus, but no significant differences were found in cerebellar gray matter. Significant differences between control and AD tissue ratios (prefrontal cortex to cerebellum gray matter, hippocampus to cerebellum gray matter) were present for [18F]flortaucipir, [18F]MK6240, and [18F]PI2620. **P < 0.01. ***P < 0.001. ****P < 0.0001. CN = control; FT = [18F]flortaucipir; MK = [18F]MK6240; ns = not significant; PI = [18F]PI2620.
- FIGURE 3.
Relationship between [18F]flortaucipir and [18F]MK6240 binding. (Top) Linear relationship between [18F]flortaucipir and [18F]MK6240 in prefrontal cortex, hippocampus, and cerebellar gray matter. Circles and squares indicate measurements of AD and control tissues, respectively. For prefrontal cortex and hippocampus, linear relationship close to line of origin was observed. (Bottom) Bland–Altman analysis assessing bias between [18F]flortaucipir and [18F]MK6240 uptake. Dashed lines indicate limits of agreement. Cerebellum had largest difference between measurements.
- FIGURE 4.
Relationship between [18F]flortaucipir and [18F]PI2620 binding. (Top) Linear relationship between [18F]flortaucipir and [18F]PI2620 in prefrontal cortex, hippocampus, and cerebellar gray matter. Circles and squares indicate measurements of AD and control tissues, respectively. For prefrontal cortex and hippocampus, linear relationship close to line of origin was observed. (Bottom) Bland–Altman analysis assessing bias between [18F]flortaucipir and [18F]PI2620 uptake. Dashed lines indicate limits of agreement. Cerebellum had largest difference between measurements.
- FIGURE 5.
Relationship between [18F]MK6240 and [18F]PI2620 binding. (Top) Linear relationship between [18F]MK6240 and [18F]PI2620 in prefrontal cortex, hippocampus, and cerebellar gray matter. Circles and squares indicate measurements of AD and control tissues, respectively. For prefrontal cortex and hippocampus, linear relationship close to line of origin was observed. (Bottom) Bland–Altman analysis assessing bias between [18F]MK6240 and [18F]PI2620 uptake. Dashed lines indicate limits of agreement. Cerebellum had largest difference between measurements.
Tables
Pathologic diagnosis Sex Age at death (y) Postmortem delay (h) Brain weight (g) Control F 48 43.75 NA Control F 78 19.75 NA Control F 77 17.25 1,150 Control F 82 32.50 NA Control M 76 20.50 1,320 Control M 60 7.25 1,350 Control F 74 11 1,365 Control M 71 76 1,250 Control F 90 13.37 1,050 Control F 81 29 1,275 Control M 91 6.75 1,070 Control M 69 12 1,225 AD M 63 15 1,165 Severe AD F 77 9.25 905 Severe AD M 76 8.5 1,240 Severe AD F 84 11.75 980 AD F 55 15.25 715 AD M 67 96 1,010 Severe AD M 92 13.25 1,200 AD M 66 8.5 1,075 Severe AD M 79 12.75 1,135 AD M 79 24.75 1,210 Severe AD M 76 24 1,005 AD M 73 26.25 1,120 NA = not available.
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