Clinical trial protocol: A randomized phase 2 trial of FLEXible and extended dosing of 177Lu-PSMA-617 Molecular Radioligand Therapy (FLEX-MRT)

Adrien Holzgreve; Astrid Delker; Zachary Ells; Julia Brosch-Lenz; Shaojun Zhu; Stephanie Lira; John Nikitas; Tristan Grogan; David Elashoff; Lena Unterrainer; Magnus Dahlbom; Martin Auerbach; Johannes Czernin; Jeremie Calais

Meeting ReportOncology: Clinical Therapy & Diagnosis (includes Phase 2, Phase 3, post approval studies) - GU

Clinical trial protocol: A randomized phase 2 trial of FLEXible and extended dosing of 177Lu-PSMA-617 Molecular Radioligand Therapy (FLEX-MRT)

Adrien Holzgreve, Astrid Delker, Zachary Ells, Julia Brosch-Lenz, Shaojun Zhu, Stephanie Lira, John Nikitas, Tristan Grogan, David Elashoff, Lena Unterrainer, Magnus Dahlbom, Martin Auerbach, Johannes Czernin and Jeremie Calais

Journal of Nuclear Medicine June 2024, 65 (supplement 2) 241369;

Adrien Holzgreve

1Ahmanson Translational Theranostics Division, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California, USA

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Astrid Delker

2Department of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany

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Zachary Ells

3UCLA Ahmanson Biological Imaging Center

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Julia Brosch-Lenz

4Department of Nuclear Medicine, School of Medicine, and Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany

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Shaojun Zhu

1Ahmanson Translational Theranostics Division, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California, USA

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Stephanie Lira

1Ahmanson Translational Theranostics Division, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California, USA

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John Nikitas

1Ahmanson Translational Theranostics Division, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California, USA

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Tristan Grogan

5University of California, Los Angeles

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David Elashoff

6Department of Medicine Statistics Core (DOMStat), Department of Medicine's Division of General Internal Medicine and Health Services Research, David Geffen School of Medicine, UCLA, Los Angeles, California, USA

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Lena Unterrainer

7Department of Nuclear Medicine, LMU Munich and Department of Nuclear Medicine, UCLA, Los Angeles

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Magnus Dahlbom

5University of California, Los Angeles

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Martin Auerbach

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Johannes Czernin

8Ahmanson Translational Theranostics Division, Pharmacology, University of California

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Jeremie Calais

5University of California, Los Angeles

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Journal of Nuclear Medicine

Vol. 65, Issue supplement 2

June 1, 2024

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Clinical trial protocol: A randomized phase 2 trial of FLEXible and extended dosing of 177Lu-PSMA-617 Molecular Radioligand Therapy (FLEX-MRT)