Article Figures & Data
Figures
- FIGURE 1.
Flowchart.
- FIGURE 2.
18F-FDG PET/CT performed 18 mo after surgical treatment of T2N0M0 left tonsillar squamous cell carcinoma showing, in coronal (top left), sagittal (top right), and axial (lower left) views, recurrence of squamous cell carcinoma (circle). This was confirmed by CT-guided biopsy (lower right). B = background; SUV-bw = body-weight SUV; T = tumor.
Tables
Characteristic n % Male 695 82 Median age ± σ (y) 62 8 Cancer history 161 19 HNSCC history 58 7 Smoking > 10 pack-years 797 94 Alcohol > 3 drinks/d 327 38 Primary location Oral cavity 198 23 Oropharynx 292 34 HPV+ oropharynx 56 19 HPV− oropharynx 236 81 Larynx 205 24 Hypopharynx 132 15 CUP 25 3 Initial 18F-FDG PET/CT 757 89 Stage Early 209 25 I 124 15 II 85 10 Advanced 633 74 III 133 16 IV 500 59 Treatment Surgery 394 46 Alone 213 25 Plus RT 91 11 Plus CRT 90 10 RT 458 54 Alone 151 18 Plus chemotherapy 307 36 Median year of treatment 2016 Median follow-up (mo) 31 28 HPV = human papilloma virus; CUP = carcinoma unknown primary; RT = radiotherapy; CRT = chemoradiotherapy.
- TABLE 2.
Overall Diagnostic Performance of 18F-FDG PET/CT and by Time Interval After Treatment
Parameter 18F-FDG PET/CT Subclinical recurrence Metachronous cancer PPV (%) NPV (%) Se (%) Sp (%) Acc (%) n Cur. treatment n Cur. treatment Range 3–6 mo, n = 830 88 98 98 88 93 40 16 (40) 28 (82) 7–12 mo, n = 435 84 99 99 85 91 45 20 (44) 16 13 (81) 13–24 mo, n = 596 91 99 98 93 95 21 17 (81) 25 21 (84) 25–36 mo, n = 343 90 98 97 95 95 9 7 (78) 20 19 (95) ≥37 mo, n = 358 84 98 97 86 91 11 10 (91) 23 22 (96) Anatomic site All, n = 2,566 88 98 98 89 93 126 70 (56) 118 103 (87) All T 88 100 99 96 96 All N 94 100 99 99 99 All lung M 95 100 99 99 99 All other M 97 100 95 100 100 All metachronous cancer 79 100 97 97 97 Se = sensitivity; Sp = specificity; Acc = accuracy; T = tumor; N = node; M = metastasis; Cur. treatment = curative treatment.
Cur. treatment data are number, with percentage in parentheses.
- TABLE 3.
Analysis of Predictive Factors for 18F-FDG PET/CT Recurrence Detection in Patients with Proven SCR
Risk factor Univariate analysis Multivariate analysis P OR 95% CI P OR 95% CI Age < 62 y old 1 0.989 0.755 Male 0.70 1.142 0.614–2.124 Smoking > 10 pack-years 0.26 0.957 0.896–1.022 Alcohol > 3 drinks/d 0.30 1.207 0.881–1.654 HNSCC history 0.51 1.196 0.748–1.915 Body mass index < 22 0.010 0.738 0.579–0.941 0.004 0.277 0.116–0.658 Primary location Oral cavity 0.006 2.002 1.233–3.253 0.879 1.179 0.142–9.775 Oropharynx 0.016 1.292 1.06–1.575 0.258 3.366 0.412–27.522 Larynx 0.41 0.927 0.78–1.103 Hypopharynx 0.11 1.093 0.995–1.2 CUP 0.68 0.984 0.933–1.038 1 Synchronous cancer 1 1.004 0.938–1.075 Initial PETup 0.005 1.481 1.141–1.922 0.001 25.582 7.939–82.34 Advanced stage III/IV 0.002 1.904 1.282–2.826 0.038 2.810 1.061–7.440 Initial treatment* 0.013 1.493 1.107–2.013 0.319 0.627 0.251–1.569 ↵* Surgery.
CUP = carcinoma unknown primary.
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