Table of Contents

August 1, 2024; Volume 65,Issue 8

This Month in JNM

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This Month in JNM
Journal of Nuclear Medicine August 1, 2024, 65 (8) 6A;

Discussions with Leaders

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Illuminating Cardiac Function
Heinrich Schelbert, Heiko Schöder and Johannes Czernin

Journal of Nuclear Medicine August 1, 2024, 65 (8) 1163-1165; DOI: https://doi.org/10.2967/jnumed.124.268302

The State of the Art

Open Access
An International Study of Factors Affecting Variability of Dosimetry Calculations, Part 3: Contribution from Calculating Absorbed Dose from Time-Integrated Activity
Julia Brosch-Lenz, Sara Kurkowska, Eric Frey, Yuni K. Dewaraja, John Sunderland and Carlos Uribe

Journal of Nuclear Medicine August 1, 2024, 65 (8) 1166-1172; DOI: https://doi.org/10.2967/jnumed.123.267293

Issues and Controversies

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Facilitating the End of the Linear No-Threshold Model Era
Mohan Doss

Journal of Nuclear Medicine August 1, 2024, 65 (8) 1173-1174; DOI: https://doi.org/10.2967/jnumed.124.267868

Oncology

Clinical
- BRIEF COMMUNICATION
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    Dose–Response Relationship in Patients with Liver Metastases from Neuroendocrine Neoplasms Undergoing Radioembolization with ⁹⁰Y Glass Microspheres
    Masao Watanabe, Stephan Leyser, Jens Theysohn, Benedikt Schaarschmidt, Johannes Ludwig, Wolfgang P. Fendler, Alexandros Moraitis, Harald Lahner, Annie Mathew, Ken Herrmann and Manuel Weber
    
    Journal of Nuclear Medicine August 1, 2024, 65 (8) 1175-1180; DOI: https://doi.org/10.2967/jnumed.124.267774
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  Diagnostic Performance of ¹⁸F-FDG PET/CT According to Delay After Treatment to Detect Subclinical Recurrence of Head and Neck Squamous Cell Carcinoma
  Camille Clement, Jean-Christophe Leclère, Clémentine Maheo, Romain Le Pennec, Gregoire Le Gal, Olivier Delcroix, Philippe Robin, Jean Rousset, Valentin Tissot, Aziliz Gueguen, Maryne Allio, Vincent Bourbonne, Ulrike Schick, Remi Marianowski, Pierre-Yves Salaun and Ronan Abgral
  
  Journal of Nuclear Medicine August 1, 2024, 65 (8) 1181-1187; DOI: https://doi.org/10.2967/jnumed.124.267391
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  Fibroblast Activation Protein–Directed Imaging Outperforms ¹⁸F-FDG PET/CT in Malignant Mesothelioma: A Prospective, Single-Center, Observational Trial
  Lukas Kessler, Felix Schwaning, Martin Metzenmacher, Kim Pabst, Jens Siveke, Marija Trajkovic-Arsic, Benedikt Schaarschmidt, Marcel Wiesweg, Clemens Aigner, Till Plönes, Kaid Darwiche, Servet Bölükbas, Martin Stuschke, Lale Umutlu, Michael Nader, Dirk Theegarten, Rainer Hamacher, Wilfried E.E. Eberhardt, Martin Schuler, Ken Herrmann, Wolfgang P. Fendler and Hubertus Hautzel
  
  Journal of Nuclear Medicine August 1, 2024, 65 (8) 1188-1193; DOI: https://doi.org/10.2967/jnumed.124.267473
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  Prognostic Value of ¹⁸F-FDG PET/CT Assessment After Radiotherapy of Squamous Cell Carcinoma of the Anus in Patients from the National Multicentric Cohort FFCD-ANABASE
  Virginie Combet-Curt, Chloé Buchalet, Karine Le Malicot, Claire Lemanski, Emmanuel Deshayes, Nathalie Bonichon-Lamichhane, Astrid Lièvre, Florence Huguet, Ghoufrane Tlili and Véronique Vendrely
  
  Journal of Nuclear Medicine August 1, 2024, 65 (8) 1194-1201; DOI: https://doi.org/10.2967/jnumed.124.267626
- Open Access
  Diverse Imaging Methods May Influence Long-Term Oncologic Outcomes in Oligorecurrent Prostate Cancer Patients Treated with Metastasis-Directed Therapy (the PRECISE-MDT Study)
  Matteo Bauckneht, Francesco Lanfranchi, Domenico Albano, Luca Triggiani, Flavia Linguanti, Luca Urso, Rosario Mazzola, Alessio Rizzo, Elisa D’Angelo, Francesco Dondi, Eneida Mataj, Gloria Pedersoli, Elisabetta Maria Abenavoli, Luca Vaggelli, Beatrice Detti, Naima Ortolan, Antonio Malorgio, Alessia Guarneri, Federico Garrou, Matilde Fiorini, Serena Grimaldi, Pietro Ghedini, Giuseppe Carlo Iorio, Antonella Iudicello, Guido Rovera, Giuseppe Fornarini, Diego Bongiovanni, Michela Marcenaro, Filippo Maria Pazienza, Giorgia Timon, Matteo Salgarello, Manuela Racca, Mirco Bartolomei, Stefano Panareo, Umberto Ricardi, Francesco Bertagna, Filippo Alongi, Salvina Barra, Silvia Morbelli, Gianmario Sambuceti and Liliana Belgioia
  
  Journal of Nuclear Medicine August 1, 2024, 65 (8) 1202-1209; DOI: https://doi.org/10.2967/jnumed.124.267586
- Open Access
  Prostate-Specific Membrane Antigen–Targeted Imaging and Its Correlation with HOXB13 Expression
  Duminduni Hewa Angappulige, Nimrod S. Barashi, Nicholas Pickersgill, Cody Weimholt, Jingqin Luo, Ghazal Shadmani, Ziad Tarcha, Sampanna Rayamajhi, Nupam P. Mahajan, Gerald L. Andriole, Barry A. Siegel, Eric H. Kim and Kiran Mahajan
  
  Journal of Nuclear Medicine August 1, 2024, 65 (8) 1210-1216; DOI: https://doi.org/10.2967/jnumed.123.267301

Theranostics

Clinical
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  The Role of Fibroblast Activation Protein in Glioblastoma and Gliosarcoma: A Comparison of Tissue, ⁶⁸Ga-FAPI-46 PET Data, and Survival Data
  Christoph Oster, Lukas Kessler, Tobias Blau, Kathy Keyvani, Kim M. Pabst, Wolfgang P. Fendler, Pedro Fragoso Costa, Lazaros Lazaridis, Teresa Schmidt, Jonas Feldheim, Daniela Pierscianek, Hans Ulrich Schildhaus, Ulrich Sure, Yahya Ahmadipour, Christoph Kleinschnitz, Nika Guberina, Martin Stuschke, Cornelius Deuschl, Björn Scheffler, Ken Herrmann, Sied Kebir and Martin Glas
  
  Journal of Nuclear Medicine August 1, 2024, 65 (8) 1217-1223; DOI: https://doi.org/10.2967/jnumed.123.267151
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  PET/CT-Based Absorbed Dose Maps in ⁹⁰Y Selective Internal Radiation Therapy Correlate with Spatial Changes in Liver Function Derived from Dynamic MRI
  Zhonglin Lu, Daniel F. Polan, Lise Wei, Madhava P. Aryal, Kellen Fitzpatrick, Chang Wang, Kyle C. Cuneo, Joseph R. Evans, Molly E. Roseland, Joseph J. Gemmete, Jared A. Christensen, Baljendra S. Kapoor, Justin K. Mikell, Yue Cao, Greta S.P. Mok and Yuni K. Dewaraja
  
  Journal of Nuclear Medicine August 1, 2024, 65 (8) 1224-1230; DOI: https://doi.org/10.2967/jnumed.124.267421
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  Clinical Trial Protocol for VIOLET: A Single-Center, Phase I/II Trial Evaluation of Radioligand Treatment in Patients with Metastatic Castration-Resistant Prostate Cancer with [¹⁶¹Tb]Tb-PSMA-I&T
  James P. Buteau, Louise Kostos, Ramin Alipour, Price Jackson, Lachlan McInstosh, Brittany Emmerson, Mohammad B. Haskali, Jing Xie, Elizabeth Medhurst, Rajeev Ravi, Brian D. Gonzalez, Heidi Fettke, Benjamin Blyth, Luc Furic, Katie Owen, Shahneen Sandhu, Declan G. Murphy, Arun A. Azad and Michael S. Hofman
  
  Journal of Nuclear Medicine August 1, 2024, 65 (8) 1231-1238; DOI: https://doi.org/10.2967/jnumed.124.267650
- Open Access
  Interreader and Intrareader Reproducibility of ¹⁸F-Flotufolastat Image Interpretation in Patients with Newly Diagnosed or Recurrent Prostate Cancer: Data from Two Phase 3 Prospective Multicenter Studies
  Phillip H. Kuo, Giuseppe Esposito, Gary A. Ulaner, Don Yoo, Katherine Zukotynski, Gregory C. Ravizzini, Ross Penny, Matthew P. Miller, Albert Chau, Phillip Davis, Brian F. Chapin, David M. Schuster and on behalf of the SPOTLIGHT and LIGHTHOUSE study groups
  
  Journal of Nuclear Medicine August 1, 2024, 65 (8) 1239-1243; DOI: https://doi.org/10.2967/jnumed.123.267306
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  Spleen Volume Reduction Is a Reliable and Independent Biomarker for Long-Term Risk of Leukopenia Development in Peptide Receptor Radionuclide Therapy
  Lisa Steinhelfer, Friederike Jungmann, Lukas Endrös, Patrick Wenzel, Bernhard Haller, Manuel Nickel, Eva Haneder, Fabian Geisler, Katharina Götze, Alexander von Werder, Matthias Eiber, Markus R. Makowski, Rickmer Braren and Fabian Lohöfer
  
  Journal of Nuclear Medicine August 1, 2024, 65 (8) 1244-1249; DOI: https://doi.org/10.2967/jnumed.123.267098
Basic
- FEATURED BASIC SCIENCE ARTICLE
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    Synthesis of ⁶⁴Cu-, ⁵⁵Co-, and ⁶⁸Ga-Labeled Radiopharmaceuticals Targeting Neurotensin Receptor-1 for Theranostics: Adjusting In Vivo Distribution Using Multiamine Macrocycles
    German O. Fonseca Cabrera, Xinrui Ma, Wilson Lin, Tao Zhang, Weiling Zhao, Liqin Pan, Xiaomei Li, Todd E. Barnhart, Eduardo Aluicio-Sarduy, Huaifu Deng, Xuedan Wu, Kadalipura P. Rakesh, Zibo Li, Jonathan W. Engle and Zhanhong Wu
    
    Journal of Nuclear Medicine August 1, 2024, 65 (8) 1250-1256; DOI: https://doi.org/10.2967/jnumed.124.267469
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  Design of a Fibroblast Activation Protein–Targeted Radiopharmaceutical Therapy with High Tumor–to–Healthy-Tissue Ratios
  Ramesh Mukkamala, Daniel J. Carlson, Nicholas Kaine Miller, Spencer D. Lindeman, Emily Renee Bowen, Pooja Tudi, Taylor Schleinkofer, Owen C. Booth, Abigail Cox, Madduri Srinivasarao and Philip S. Low
  
  Journal of Nuclear Medicine August 1, 2024, 65 (8) 1257-1263; DOI: https://doi.org/10.2967/jnumed.124.267756

Radiobiology/Dosimetry

Clinical
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  Dosimetry of [¹⁷⁷Lu]Lu-PSMA–Targeted Radiopharmaceutical Therapies in Patients with Prostate Cancer: A Comparative Systematic Review and Metaanalysis
  Zachary Ells, Tristan R. Grogan, Johannes Czernin, Magnus Dahlbom and Jeremie Calais
  
  Journal of Nuclear Medicine August 1, 2024, 65 (8) 1264-1271; DOI: https://doi.org/10.2967/jnumed.124.267452
- Open Access
  Impact of the Reference Multiple-Time-Point Dosimetry Protocol on the Validity of Single-Time-Point Dosimetry for [¹⁷⁷Lu]Lu-PSMA-I&T Therapy
  Sandra Resch, Sibylle I. Ziegler, Gabriel Sheikh, Lena M. Unterrainer, Mathias J. Zacherl, Peter Bartenstein, Guido Böning, Julia Brosch-Lenz and Astrid Delker
  
  Journal of Nuclear Medicine August 1, 2024, 65 (8) 1272-1278; DOI: https://doi.org/10.2967/jnumed.123.266871

Cardiovascular

Clinical
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  Factors Associated with Myocardial Uptake on Oncologic Somatostatin PET Investigations and Differentiation from Myocardial Uptake of Acute Myocarditis
  Thomas Larive, Caroline Boursier, Marine Claudin, Jeanne Varlot, Laura Filippetti, Olivier Huttin, Véronique Roch, Laetitia Imbert, Matthieu Doyen, Aurélien Lambert, Damien Mandry, Zohra Lamiral, Elodie Chevalier and Pierre-Yves Marie
  
  Journal of Nuclear Medicine August 1, 2024, 65 (8) 1279-1285; DOI: https://doi.org/10.2967/jnumed.123.267219

Neurology

Clinical
- Open Access
  Performing [¹⁸F]MFBG Long–Axial-Field-of-View PET/CT Without Sedation or General Anesthesia for Imaging of Children with Neuroblastoma
  Lise Borgwardt, Jesper Brok, Kim Francis Andersen, Jacob Madsen, Nicholas Gillings, Marie Øbro Fosbøl, Charlotte Lund Denholt, Ida Nymann Petersen, Louise Sørup Sørensen, Lotte Hahn Enevoldsen, Peter Sandor Oturai, Helle Hjort Johannesen, Liselotte Højgaard, Christina Schulze, Eunice Saxtoft, Flemming Andersen and Barbara Malene Fischer
  
  Journal of Nuclear Medicine August 1, 2024, 65 (8) 1286-1292; DOI: https://doi.org/10.2967/jnumed.123.267256
Basic
- Open Access
  Noninvasive Diagnostic Method to Objectively Measure Olfaction and Diagnose Smell Disorders by a Molecularly Targeted Fluorescence Imaging Agent
  Dauren Adilbay, Junior Gonzales, Marianna Zazhytska, Paula Demetrio de Souza Franca, Sheryl Roberts, Tara D. Viray, Raik Artschwager, Snehal Patel, Albana Kodra, Jonathan B. Overdevest, Chun Yuen Chow, Glenn F. King, Sanjay K. Jain, Alvaro A. Ordonez, Laurence S. Carroll, Stavros Lomvardas, Thomas Reiner and Nagavarakishore Pillarsetty
  
  Journal of Nuclear Medicine August 1, 2024, 65 (8) 1293-1300; DOI: https://doi.org/10.2967/jnumed.123.266123

Molecular Imaging

Basic
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  hHEPATO-Cy5, a Bimodal Tracer for Image-Guided Hepatobiliary Surgery
  Daphne D.D. Rietbergen, Tessa Buckle, Leon J. Slof, Maarten P. van Meerbeek, Clarize M. de Korne, Mick M. Welling, Matthias N. van Oosterom, Kevin Bauwens, Meta Roestenberg, Julia Kloetzl and Fijs W.B. van Leeuwen
  
  Journal of Nuclear Medicine August 1, 2024, 65 (8) 1301-1306; DOI: https://doi.org/10.2967/jnumed.123.266715

AI/Advanced Image Analysis

Basic
- Open Access
  RadShap: An Explanation Tool for Highlighting the Contributions of Multiple Regions of Interest to the Prediction of Radiomic Models
  Nicolas Captier, Fanny Orlhac, Narinée Hovhannisyan-Baghdasarian, Marie Luporsi, Nicolas Girard and Irène Buvat
  
  Journal of Nuclear Medicine August 1, 2024, 65 (8) 1307-1312; DOI: https://doi.org/10.2967/jnumed.124.267434

Physics and Instrumentation

Clinical
- Open Access
  Validation and Evaluation of a Vendor-Provided Head Motion Correction Algorithm on the uMI Panorama PET/CT System
  Fei Kang, Zhaojuan Xie, Wenhui Ma, Zhiyong Quan, Guiyu Li, Kun Guo, Xiang Li, Taoqi Ma, Weidong Yang, Yizhang Zhao, Hongyuan Yi, Yumo Zhao, Yihuan Lu and Jing Wang
  
  Journal of Nuclear Medicine August 1, 2024, 65 (8) 1313-1319; DOI: https://doi.org/10.2967/jnumed.124.267446
- FEATURED ARTICLE OF THE MONTH
  - Open Access
    Performance Characteristics of the NeuroEXPLORER, a Next-Generation Human Brain PET/CT Imager
    Hongdi Li, Ramsey D. Badawi, Simon R. Cherry, Kathryn Fontaine, Liuchun He, Shannan Henry, Ansel T. Hillmer, Lingzhi Hu, Nikkita Khattar, Edwin K. Leung, Tiantian Li, Yusheng Li, Chi Liu, Peng Liu, Zhenrui Lu, Stanislaw Majewski, David Matuskey, Evan D. Morris, Tim Mulnix, Negar Omidvari, Suranjana Samanta, Aaron Selfridge, Xishan Sun, Takuya Toyonaga, Tommaso Volpi, Tianyi Zeng, Terry Jones, Jinyi Qi and Richard E. Carson
    
    Journal of Nuclear Medicine August 1, 2024, 65 (8) 1320-1326; DOI: https://doi.org/10.2967/jnumed.124.267767

The Illustrated Post

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Brain Metabolic Correlates of the Off-Target Effects of Enzalutamide on the Central Nervous System of Patients with Advanced Prostate Cancer
Matteo Bauckneht, Giuseppe Fornarini, Tania Di Raimondo, Matteo Pardini, Maria Isabella Donegani, Giuseppe Luigi Banna, Massimo Di Maio and Silvia Morbelli

Journal of Nuclear Medicine August 1, 2024, 65 (8) 1327; DOI: https://doi.org/10.2967/jnumed.124.267526
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[⁶⁸Ga]Ga-FAPI-46 False-Positive Uptake After Chemotherapy in Nonseminomatous Germ Cell Tumor Metastatic Lesions
Vinicius Ludwig, Peter George Maliha, John Shen, David Tonnelet, Steve Raman, Mark S. Litwin and Jeremie Calais

Journal of Nuclear Medicine August 1, 2024, 65 (8) 1328-1329; DOI: https://doi.org/10.2967/jnumed.124.267609

Letters to the Editor

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Nuclear Pharmacy Training in the Era of Theranostics: Toward Meeting the Needs of Nuclear Medicine Patients for Comprehensive Pharmaceutical Care
Isabelle Laverdière, Gilbert Matte, Martin Darveau and Jean-Mathieu Beauregard

Journal of Nuclear Medicine August 1, 2024, 65 (8) 1330-1331; DOI: https://doi.org/10.2967/jnumed.124.267603