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Research ArticleThe State of the Art
Open Access

An International Study of Factors Affecting Variability of Dosimetry Calculations, Part 3: Contribution from Calculating Absorbed Dose from Time-Integrated Activity

Julia Brosch-Lenz, Sara Kurkowska, Eric Frey, Yuni K. Dewaraja, John Sunderland and Carlos Uribe
Journal of Nuclear Medicine August 2024, 65 (8) 1166-1172; DOI: https://doi.org/10.2967/jnumed.123.267293
Julia Brosch-Lenz
1Department of Nuclear Medicine, Rechts der Isar Medical Center, Technical University of Munich, Munich, Germany;
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Sara Kurkowska
2Department of Nuclear Medicine, Pomeranian Medical University, Szczecin, Poland;
3Department of Integrative Oncology, BC Cancer Research Institute, Vancouver, British Columbia, Canada;
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Eric Frey
4Rapid, LLC, Baltimore, Maryland;
5Department of Radiology, Johns Hopkins University, Baltimore, Maryland;
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Yuni K. Dewaraja
6Department of Radiology, University of Michigan, Ann Arbor, Michigan;
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John Sunderland
7Department of Radiology, University of Iowa, Iowa City, Iowa;
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Carlos Uribe
3Department of Integrative Oncology, BC Cancer Research Institute, Vancouver, British Columbia, Canada;
8Molecular Imaging and Therapy, BC Cancer, Vancouver, British Columbia, Canada; and
9Department of Radiology, University of British Columbia, Vancouver, British Columbia, Canada
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  • FIGURE 1.
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    FIGURE 1.

    (A and B) Dosimetry results for patients A (A) and B (B), when performed by 2 MPs using same dosimetry methods. (C and D) Percentage difference in ADs between 2 MPs for patients A (C) and B (D). PD = percentage difference.

  • FIGURE 2.
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    FIGURE 2.

    Range of ADs per organ for all possible combinations of VOI formats and scan time point used for patient A. “All Liver Results” illustrates range of liver AD results when results from both scenarios—with and without lesions included inside liver—were combined.

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    FIGURE 3.

    QCD for all possible 18 combinations of VOI formats and time points, with or without mass scaling, or using average mass for mass scaling, used to yield ADs in Figure 2. Furthermore, combination of all liver results—with and without lesions included—are given in “All Liver Results.”

  • FIGURE 4.
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    FIGURE 4.

    Mean AD per region for different methods that were used for calculation. Number of submissions that included each method is provided in Table 1. LD = local deposition; MC = MC dosimetry simulations; OSV = organ S value; VSV = voxel S value–based dosimetry.

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    FIGURE 5.

    Mean AD per region using different available software solutions for all regions of patients A and B. OS = open-source/freely available and well-validated dosimetry non-CS, including in-house solutions.

  • FIGURE 6.
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    FIGURE 6.

    QCD per organ for different dosimetry methods. LD = local deposition; MC = MC dosimetry simulations.

  • FIGURE 7.
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    FIGURE 7.

    QCD per organ for different dosimetry software. OS = open-source/freely available dosimetry software, including in-house solutions and well-validated software.

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    TABLE 1.

    Number of Submissions per Patient for Each Dosimetry Method and Software

    ParameterSubmissions (n)
    Dosimetry method
     OSV10
     VSV9
     Local deposition (organ and voxel level)4
     MC simulation2
    Dosimetry software
     Noncommercial15
     CS 14
     CS 23
     CS 32
     CS 41
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    TABLE 2.

    P Value Results of Mann–Whitney U Test Between Voxel- and Organ-Level Dosimetry

    PatientLiverSpleenR kidneyL kidneyTotal kidneyLesion 1Lesion 2Lesion 3Lesion 4
    A0.29<0.01*0.04*0.01*0.300.070.08
    B0.300.01*0.05*0.280.150.180.380.18
    • ↵* Statistically significant difference (P ≤ 0.05).

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    TABLE 3.

    P value Results of Mann–Whitney U Test Between CS and Non-CS

    PatientLiverSpleenR kidneyL kidneyTotal kidneyLesion 1Lesion 2Lesion 3Lesion 4
    A0.140.180.080.120.200.03*0.01*
    B0.01*0.03*0.02*0.190.070.05*0.06<0.01*
    • ↵* Statistically significant difference (P ≤ 0.05).

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Journal of Nuclear Medicine: 65 (8)
Journal of Nuclear Medicine
Vol. 65, Issue 8
August 1, 2024
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An International Study of Factors Affecting Variability of Dosimetry Calculations, Part 3: Contribution from Calculating Absorbed Dose from Time-Integrated Activity
Julia Brosch-Lenz, Sara Kurkowska, Eric Frey, Yuni K. Dewaraja, John Sunderland, Carlos Uribe
Journal of Nuclear Medicine Aug 2024, 65 (8) 1166-1172; DOI: 10.2967/jnumed.123.267293

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An International Study of Factors Affecting Variability of Dosimetry Calculations, Part 3: Contribution from Calculating Absorbed Dose from Time-Integrated Activity
Julia Brosch-Lenz, Sara Kurkowska, Eric Frey, Yuni K. Dewaraja, John Sunderland, Carlos Uribe
Journal of Nuclear Medicine Aug 2024, 65 (8) 1166-1172; DOI: 10.2967/jnumed.123.267293
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