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Research ArticleFEATURED ARTICLE OF THE MONTH

Deescalated 225Ac-PSMA-617 Versus 177Lu/225Ac-PSMA-617 Cocktail Therapy: A Single-Center Retrospective Analysis of 233 Patients

Hendrik Rathke, Erik Winter, Frank Bruchertseifer, Manuel Röhrich, Frederik Lars Giesel, Uwe Haberkorn, Alfred Morgenstern and Clemens Kratochwil
Journal of Nuclear Medicine July 2024, 65 (7) 1057-1063; DOI: https://doi.org/10.2967/jnumed.123.267206
Hendrik Rathke
1Department of Nuclear Medicine, Heidelberg University Hospital, Heidelberg, Germany;
2Department of Nuclear Medicine, Bern University Hospital, Bern, Switzerland;
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Erik Winter
1Department of Nuclear Medicine, Heidelberg University Hospital, Heidelberg, Germany;
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Frank Bruchertseifer
3Joint Research Centre, European Commission, Karlsruhe, Germany;
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Manuel Röhrich
1Department of Nuclear Medicine, Heidelberg University Hospital, Heidelberg, Germany;
4Department of Nuclear Medicine, Mainz University Hospital, Mainz, Germany; and
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Frederik Lars Giesel
5Department of Nuclear Medicine, University Hospital Duesseldorf, Duesseldorf, Germany
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Uwe Haberkorn
1Department of Nuclear Medicine, Heidelberg University Hospital, Heidelberg, Germany;
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Alfred Morgenstern
3Joint Research Centre, European Commission, Karlsruhe, Germany;
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Clemens Kratochwil
1Department of Nuclear Medicine, Heidelberg University Hospital, Heidelberg, Germany;
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Article Information

vol. 65 no. 7 1057-1063
DOI 
https://doi.org/10.2967/jnumed.123.267206
PubMed 
38844358

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication December 17, 2023
  • Accepted for publication April 25, 2024
  • Published online July 1, 2024.

Article Versions

  • previous version (June 6, 2024 - 10:30).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2024 by the Society of Nuclear Medicine and Molecular Imaging.

Author Information

  1. Hendrik Rathke1,2,
  2. Erik Winter1,
  3. Frank Bruchertseifer3,
  4. Manuel Röhrich1,4,
  5. Frederik Lars Giesel5,
  6. Uwe Haberkorn1,
  7. Alfred Morgenstern3 and
  8. Clemens Kratochwil1
  1. 1Department of Nuclear Medicine, Heidelberg University Hospital, Heidelberg, Germany;
  2. 2Department of Nuclear Medicine, Bern University Hospital, Bern, Switzerland;
  3. 3Joint Research Centre, European Commission, Karlsruhe, Germany;
  4. 4Department of Nuclear Medicine, Mainz University Hospital, Mainz, Germany; and
  5. 5Department of Nuclear Medicine, University Hospital Duesseldorf, Duesseldorf, Germany
  1. For correspondence or reprints, contact Hendrik Rathke (hendrik.rathke{at}ksgr.ch).
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    Scientific Reports 2024 14 1
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    Nuclear Medicine and Biology 2025 142-143
  • Long-Term Safety and Survival Outcomes of [225Ac]Ac-PSMA (Prostate-Specific Membrane Antigen) and [225Ac]Ac-/[177Lu]Lu-PSMA (TANDEM) Radioligand Therapy (PRLT) in Metastatic Castration-Resistant Prostate Cancer
    Elisabetta Perrone, Alessandro Giordano, Maria Lucia Calcagni, Lucia Leccisotti, Roberto Moretti, Aleksandr Eismant, Kriti Ghai, Tanay Parkar, Aditi Mishra, Axel Heidenreich, Ralph M. Wirtz, Jörg Müller, Lukas Greifenstein, Richard P. Baum
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  • 225Ac-PSMA-617 Augmentation After Insufficient Response Under 177Lu-PSMA-617 Radioligand Therapy in mCRPC: Evaluation of Outcome and Safety From a Prospective Registry (REALITY Study)
    Florian Rosar, Fadi Khreish, Lea Sophie Nagel, Arne Blickle, Caroline Burgard, Sven Petto, Moritz B. Bastian, Tilman Speicher, Mark Bartholomä, Stephan Maus, Andrea Schaefer-Schuler, Samer Ezziddin
    Clinical Nuclear Medicine 2025 50 4
  • Evaluating Xerostomia as a side effect of [255Ac]Ac-PSMA therapy in prostate cancer: a systematic review and meta-analysis
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    European Journal of Nuclear Medicine and Molecular Imaging 2025
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  • The role of PSMA-based radioligand therapy in hormone-sensitive prostate cancer
    Riccardo Laudicella, Matteo Bauckneht, Irene A Burger, Alberto Cacciola, Stefano Fanti, Andrea Farolfi, Vincenzo Ficarra, Andrei Iagaru, Virginia Liberini, Stefano Pergolizzi, Giulia Santo, Irene Virgolini, Fabio Minutoli, Sergio Baldari
    European Journal of Nuclear Medicine and Molecular Imaging 2025 52 7

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Journal of Nuclear Medicine: 65 (7)
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July 1, 2024
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Deescalated 225Ac-PSMA-617 Versus 177Lu/225Ac-PSMA-617 Cocktail Therapy: A Single-Center Retrospective Analysis of 233 Patients
Hendrik Rathke, Erik Winter, Frank Bruchertseifer, Manuel Röhrich, Frederik Lars Giesel, Uwe Haberkorn, Alfred Morgenstern, Clemens Kratochwil
Journal of Nuclear Medicine Jul 2024, 65 (7) 1057-1063; DOI: 10.2967/jnumed.123.267206

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Deescalated 225Ac-PSMA-617 Versus 177Lu/225Ac-PSMA-617 Cocktail Therapy: A Single-Center Retrospective Analysis of 233 Patients
Hendrik Rathke, Erik Winter, Frank Bruchertseifer, Manuel Röhrich, Frederik Lars Giesel, Uwe Haberkorn, Alfred Morgenstern, Clemens Kratochwil
Journal of Nuclear Medicine Jul 2024, 65 (7) 1057-1063; DOI: 10.2967/jnumed.123.267206
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Keywords

  • 225Ac
  • 177Lu
  • TAT
  • PSMA
  • mCRPC
  • cocktail
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