In Vivo PET Imaging of 89Zr-Labeled Natural Killer Cells and the Modulating Effects of a Therapeutic Antibody

Truc T. Pham; Alicia Chenoweth; Natasha Patel; Arshiya Banu; Gabriel Osborn; Philip J. Blower; Sophia N. Karagiannis; Michelle T. Ma

doi:10.2967/jnumed.124.267876

Research ArticleBasic Science Investigation

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In Vivo PET Imaging of ⁸⁹Zr-Labeled Natural Killer Cells and the Modulating Effects of a Therapeutic Antibody

Truc T. Pham, Alicia Chenoweth, Natasha Patel, Arshiya Banu, Gabriel Osborn, Philip J. Blower, Sophia N. Karagiannis and Michelle T. Ma

Journal of Nuclear Medicine July 2024, 65 (7) 1035-1042; DOI: https://doi.org/10.2967/jnumed.124.267876

Truc T. Pham

1Department of Imaging Chemistry and Biology, School of Bioengineering and Imaging Sciences, King’s College London, London, United Kingdom;

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Alicia Chenoweth

2St. John’s Institute of Dermatology, School of Basic and Medical Biosciences, King’s College London, London, United Kingdom; and

3Breast Cancer Now Research Unit, School of Cancer and Pharmaceutical Sciences, King’s College London, Guy’s Hospital, London, United Kingdom

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Natasha Patel

1Department of Imaging Chemistry and Biology, School of Bioengineering and Imaging Sciences, King’s College London, London, United Kingdom;

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Arshiya Banu

1Department of Imaging Chemistry and Biology, School of Bioengineering and Imaging Sciences, King’s College London, London, United Kingdom;

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Gabriel Osborn

2St. John’s Institute of Dermatology, School of Basic and Medical Biosciences, King’s College London, London, United Kingdom; and

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Philip J. Blower

1Department of Imaging Chemistry and Biology, School of Bioengineering and Imaging Sciences, King’s College London, London, United Kingdom;

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Sophia N. Karagiannis

2St. John’s Institute of Dermatology, School of Basic and Medical Biosciences, King’s College London, London, United Kingdom; and

3Breast Cancer Now Research Unit, School of Cancer and Pharmaceutical Sciences, King’s College London, Guy’s Hospital, London, United Kingdom

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Michelle T. Ma

1Department of Imaging Chemistry and Biology, School of Bioengineering and Imaging Sciences, King’s College London, London, United Kingdom;

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Journal of Nuclear Medicine

Vol. 65, Issue 7

July 1, 2024

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In Vivo PET Imaging of ⁸⁹Zr-Labeled Natural Killer Cells and the Modulating Effects of a Therapeutic Antibody

Truc T. Pham, Alicia Chenoweth, Natasha Patel, Arshiya Banu, Gabriel Osborn, Philip J. Blower, Sophia N. Karagiannis, Michelle T. Ma

Journal of Nuclear Medicine Jul 2024, 65 (7) 1035-1042; DOI: 10.2967/jnumed.124.267876

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In Vivo PET Imaging of ⁸⁹Zr-Labeled Natural Killer Cells and the Modulating Effects of a Therapeutic Antibody

Truc T. Pham, Alicia Chenoweth, Natasha Patel, Arshiya Banu, Gabriel Osborn, Philip J. Blower, Sophia N. Karagiannis, Michelle T. Ma

Journal of Nuclear Medicine Jul 2024, 65 (7) 1035-1042; DOI: 10.2967/jnumed.124.267876

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Keywords

natural killer cell
ADCC
trastuzumab
HER2 receptor
cell tracking

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