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Journal of Nuclear Medicine

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Research ArticleClinical Investigation
Open Access

Utility of PSMA PET/CT in Staging and Restaging of Renal Cell Carcinoma: A Systematic Review and Metaanalysis

Moe S. Sadaghiani, Saradha Baskaran, Michael A. Gorin, Steven P. Rowe, Jean-Claude Provost, Iryna Teslenko, Roman Bilyk, Hong An and Sara Sheikhbahaei
Journal of Nuclear Medicine July 2024, 65 (7) 1007-1012; DOI: https://doi.org/10.2967/jnumed.124.267417
Moe S. Sadaghiani
1Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland;
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Saradha Baskaran
2Lantheus, Bedford, Massachusetts;
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Michael A. Gorin
3Milton and Carroll Petrie Department of Urology, Icahn School of Medicine at Mount Sinai, New York, New York; and
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Steven P. Rowe
4Department of Radiology, University of North Carolina School of Medicine, Chapel Hill, North Carolina
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Jean-Claude Provost
2Lantheus, Bedford, Massachusetts;
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Iryna Teslenko
2Lantheus, Bedford, Massachusetts;
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Roman Bilyk
2Lantheus, Bedford, Massachusetts;
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Hong An
2Lantheus, Bedford, Massachusetts;
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Sara Sheikhbahaei
1Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland;
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  • FIGURE 1.
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    FIGURE 1.

    Flowchart of systematic review.

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    FIGURE 2.

    Lesion-based detection rate of PSMA PET/CT in staging and restaging of RCC (all included studies).

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    FIGURE 3.

    Lesion-based detection rate of PSMA PET/CT in restaging of patients with metastatic or recurrent RCC.

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    FIGURE 4.

    Detection rate of PSMA PET/CT in staging or evaluation of primary RCC.

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    FIGURE 5.

    Lesion-based detection rate of 68Ga-based PSMA radiotracers in restaging of patients with metastatic RCC.

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    FIGURE 6.

    Lesion-based detection rate of 18F-DCFPyL PSMA in restaging of metastatic RCC (A), in comparison with conventional imaging modalities (B).

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    FIGURE 7.

    Funnel plot of publication bias on detection rate of PSMA PET/CT in restaging of metastatic RCC (A) and evaluation of primary lesions (B).

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Journal of Nuclear Medicine: 65 (7)
Journal of Nuclear Medicine
Vol. 65, Issue 7
July 1, 2024
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Utility of PSMA PET/CT in Staging and Restaging of Renal Cell Carcinoma: A Systematic Review and Metaanalysis
Moe S. Sadaghiani, Saradha Baskaran, Michael A. Gorin, Steven P. Rowe, Jean-Claude Provost, Iryna Teslenko, Roman Bilyk, Hong An, Sara Sheikhbahaei
Journal of Nuclear Medicine Jul 2024, 65 (7) 1007-1012; DOI: 10.2967/jnumed.124.267417

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Utility of PSMA PET/CT in Staging and Restaging of Renal Cell Carcinoma: A Systematic Review and Metaanalysis
Moe S. Sadaghiani, Saradha Baskaran, Michael A. Gorin, Steven P. Rowe, Jean-Claude Provost, Iryna Teslenko, Roman Bilyk, Hong An, Sara Sheikhbahaei
Journal of Nuclear Medicine Jul 2024, 65 (7) 1007-1012; DOI: 10.2967/jnumed.124.267417
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Keywords

  • renal cell carcinoma
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  • PSMA PET/CT
  • metaanalysis
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