Detecting High-Dose Methotrexate–Induced Brain Changes in Pediatric and Young Adult Cancer Survivors Using [18F]FDG PET/MRI: A Pilot Study

Lucia Baratto; Shashi B. Singh; Sharon E. Williams; Sheri L. Spunt; Jarrett Rosenberg; Lisa Adams; Vidyani Suryadevara; Michael Iv; Heike Daldrup-Link

doi:10.2967/jnumed.123.266760

Research ArticleClinical Investigation

Detecting High-Dose Methotrexate–Induced Brain Changes in Pediatric and Young Adult Cancer Survivors Using [¹⁸F]FDG PET/MRI: A Pilot Study

Lucia Baratto, Shashi B. Singh, Sharon E. Williams, Sheri L. Spunt, Jarrett Rosenberg, Lisa Adams, Vidyani Suryadevara, Michael Iv and Heike Daldrup-Link

Journal of Nuclear Medicine June 2024, 65 (6) 864-871; DOI: https://doi.org/10.2967/jnumed.123.266760

Lucia Baratto

1Division of Pediatric Radiology, Department of Radiology, Stanford University School of Medicine, Stanford, California;

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Shashi B. Singh

1Division of Pediatric Radiology, Department of Radiology, Stanford University School of Medicine, Stanford, California;

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Sharon E. Williams

2Child and Adolescent Psychiatry Clinic, Department of Psychiatry and Behavioral Sciences–Child and Adolescent Psychiatry and Child Development, Stanford University, Stanford, California;

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Sheri L. Spunt

3Department of Pediatrics–Hematology/Oncology, Lucile Packard Children’s Hospital, Stanford University, Stanford, California;

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Jarrett Rosenberg

4Department of Radiology, Stanford University School of Medicine, Stanford University, Stanford, California; and

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Lisa Adams

1Division of Pediatric Radiology, Department of Radiology, Stanford University School of Medicine, Stanford, California;

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Vidyani Suryadevara

1Division of Pediatric Radiology, Department of Radiology, Stanford University School of Medicine, Stanford, California;

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Michael Iv

5Neuroimaging Division, Radiology Department, Stanford Health Care, Stanford University, Stanford, California

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Heike Daldrup-Link

1Division of Pediatric Radiology, Department of Radiology, Stanford University School of Medicine, Stanford, California;

3Department of Pediatrics–Hematology/Oncology, Lucile Packard Children’s Hospital, Stanford University, Stanford, California;

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Journal of Nuclear Medicine

Vol. 65, Issue 6

June 1, 2024

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Detecting High-Dose Methotrexate–Induced Brain Changes in Pediatric and Young Adult Cancer Survivors Using [¹⁸F]FDG PET/MRI: A Pilot Study

Lucia Baratto, Shashi B. Singh, Sharon E. Williams, Sheri L. Spunt, Jarrett Rosenberg, Lisa Adams, Vidyani Suryadevara, Michael Iv, Heike Daldrup-Link

Journal of Nuclear Medicine Jun 2024, 65 (6) 864-871; DOI: 10.2967/jnumed.123.266760

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Detecting High-Dose Methotrexate–Induced Brain Changes in Pediatric and Young Adult Cancer Survivors Using [¹⁸F]FDG PET/MRI: A Pilot Study

Lucia Baratto, Shashi B. Singh, Sharon E. Williams, Sheri L. Spunt, Jarrett Rosenberg, Lisa Adams, Vidyani Suryadevara, Michael Iv, Heike Daldrup-Link

Journal of Nuclear Medicine Jun 2024, 65 (6) 864-871; DOI: 10.2967/jnumed.123.266760

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Keywords

cancer survivors
methotrexate
neurocognitive test
neurotoxicity
PET

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Detecting High-Dose Methotrexate–Induced Brain Changes in Pediatric and Young Adult Cancer Survivors Using [¹⁸F]FDG PET/MRI: A Pilot Study

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