Single-Time-Point Renal Dosimetry Using Nonlinear Mixed-Effects Modeling and Population-Based Model Selection in [177Lu]Lu-PSMA-617 Therapy

Deni Hardiansyah; Elham Yousefzadeh-Nowshahr; Felix Kind; Ambros J. Beer; Juri Ruf; Gerhard Glatting; Michael Mix

doi:10.2967/jnumed.123.266268

Research ArticleClinical Investigation

Single-Time-Point Renal Dosimetry Using Nonlinear Mixed-Effects Modeling and Population-Based Model Selection in [¹⁷⁷Lu]Lu-PSMA-617 Therapy

Deni Hardiansyah, Elham Yousefzadeh-Nowshahr, Felix Kind, Ambros J. Beer, Juri Ruf, Gerhard Glatting and Michael Mix

Journal of Nuclear Medicine April 2024, 65 (4) 566-572; DOI: https://doi.org/10.2967/jnumed.123.266268

Deni Hardiansyah

1Medical Physics and Biophysics, Physics Department, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok, Indonesia;

2Medical Radiation Physics, Department of Nuclear Medicine, Ulm University, Ulm, Germany;

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Elham Yousefzadeh-Nowshahr

2Medical Radiation Physics, Department of Nuclear Medicine, Ulm University, Ulm, Germany;

3Department of Nuclear Medicine, Ulm University, Ulm, Germany;

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Felix Kind

4Department of Nuclear Medicine, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; and

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Ambros J. Beer

3Department of Nuclear Medicine, Ulm University, Ulm, Germany;

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Juri Ruf

4Department of Nuclear Medicine, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; and

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Gerhard Glatting

2Medical Radiation Physics, Department of Nuclear Medicine, Ulm University, Ulm, Germany;

3Department of Nuclear Medicine, Ulm University, Ulm, Germany;

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Michael Mix

4Department of Nuclear Medicine, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; and

5Nuclear Medicine Division, Department of Medical Imaging and Clinical Oncology, Faculty of Medicine and Health Science, Stellenbosch University, Cape Town, South Africa

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April 1, 2024

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Single-Time-Point Renal Dosimetry Using Nonlinear Mixed-Effects Modeling and Population-Based Model Selection in [¹⁷⁷Lu]Lu-PSMA-617 Therapy

Deni Hardiansyah, Elham Yousefzadeh-Nowshahr, Felix Kind, Ambros J. Beer, Juri Ruf, Gerhard Glatting, Michael Mix

Journal of Nuclear Medicine Apr 2024, 65 (4) 566-572; DOI: 10.2967/jnumed.123.266268

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Single-Time-Point Renal Dosimetry Using Nonlinear Mixed-Effects Modeling and Population-Based Model Selection in [¹⁷⁷Lu]Lu-PSMA-617 Therapy

Deni Hardiansyah, Elham Yousefzadeh-Nowshahr, Felix Kind, Ambros J. Beer, Juri Ruf, Gerhard Glatting, Michael Mix

Journal of Nuclear Medicine Apr 2024, 65 (4) 566-572; DOI: 10.2967/jnumed.123.266268

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An International Study of Factors Affecting Variability of Dosimetry Calculations, Part 4: Impact of Fitting Functions in Estimated Absorbed Doses

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Keywords

STP dosimetry
Akaike weight
model selection
NLME modeling
PSMA

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