Article Figures & Data
Figures
- FIGURE 1.
Standardized display for visual interpretation of 4 cases: 4-min scan considered too noisy for visual interpretation (upper left), 4-min scan interpreted as artificial because of barbell shape of left striatum (upper right), and two 30-min scans interpreted as neurodegeneration-typical reduction (lower left) and normal (lower right). Top of each panel shows 10 transversal distribution-volume-ratio slices of 4-mm thickness from superior to inferior edge of striatum with maximum of color table individually scaled to maximum intensity in 10 images. Bottom of each panel shows transversal distribution-volume-ratio image of 12-mm thickness through center of striatum with maximum of color table scaled to fixed upper distribution-volume-ratio threshold optimized previously.
- FIGURE 2.
(A) Results of visual interpretation. (B) Transversal 12-mm SPECT images with 4-min vs. 30-min scan durations for 4 representative cases: too noisy on 4-min scan (male, 83 y, 175 MBq, 210-min uptake period), artificial on 4-min scan (male, 81 y, 182 MBq, 188-min uptake period), intrareader discrepancy (normal vs. reduced) on 4-min scan (male, 68 y, 183 MBq, 177-min uptake period), and discrepant classification between 4-min (reduced) and 30-min (normal) scans (female, 77 y, 196 MBq, 268-min uptake period).
- FIGURE 3.
Representative examples in which scan duration had no relevant impact down to 4 min (transversal 12-mm images; top: female, 44 y, 200 MBq, 186-min uptake period; bottom: female, 72 y, 200 MBq, 220-min uptake period).
- FIGURE 4.
Scatterplots of unilateral putamen SBR (n = 1,280) with reduced vs. 30-min scan duration, and plot of R2. Dashed lines indicate R2 expected for putamen SBR from 2 short-term repeat DAT SPECT scans of same patient with 5% test–retest variability.
- FIGURE 5.
Histograms of putamen SBR (minimum of both hemispheres, n = 640), and effect size d of distance between 2 gaussian functions (according to Eq. 2). Fit by sum of 2 gaussians is indicated by continuous line. Remaining fit parameters are given in Supplemental Table 1. HV = hottest-voxels.
- FIGURE 6.
Balanced accuracy of network trained for automatic classification of MPH DAT SPECT with 30-min scan duration in same 213 test cases with varying scan duration.
Additional Files
Supplemental Data
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